Synthesis of Bone Scaffold for Pediatric Bone Defects Using 3D Printing

Pediatric bone defects, requiring surgical interventions and implants, include malignant and nonmalignant bone tumors and trauma fractures. Malignant bone tumors (MBT), such as Osteosarcoma and Ewing sarcoma, are aggressive primary cancers that affect growing adolescent bones (10- to 19-year-olds) and require complex reconstruction due to large bone excision during surgical interventions. Pediatric bone fractures requiring surgical interventions peak in 10- to 14-year-olds and are a major public health concern in the US with an impact on patients, parents, and healthcare costs of approx. 350 billion. These diseases require bone tissue replacement in changing bones. Bone reconstruction and medical implant design for growing pediatric bones have unique challenges due to active growth and there is a greater need for active, resorbable, and patient-specific implants to prevent growth impediments. The current available pediatric implant is limited in addressing these needs and is primarily addressed by static metallic implants designed for adults. We plan to work towards the design and synthesis of a bone scaffold by modifying a CAD model considering the size of the porosity in the structure of the pediatric bone. This modified model will be 3D printed and subjected to tests to evaluate the strength and composition of the scaffold. Afterwards, the scaffold is used for cell culture in hopes of eliciting cellular response for bone formation and cell regeneration, since a key factor to assess is whether the scaffold will grow with the bone, or the bone will grow with the scaffold. This is done to support the attachment of cells on the surface of the bone to actively support bone modeling processes under structural changes of growing bones

Els orígens familiars dels Cartellà al llarg de deu generacions (s. X-XIV)

L'estudi pretén investigar els ascendents familiars de Guillem Galceran de Cartellà i de la seva esposa Blanca de Creixell, detallant els arbres genealògics de les tres famílies principals que els componen: els Hostoles, a més dels Cartellà i dels Creixell. L'anàlisi detallada i la recopilació de tota la documentació disponible, molta de la qual inèdita, és aquí presentada de forma abreujada, permet aclarir molts punts fins ara dubtosos d'aquestes genealogies i proporciona materials de notable interès per a la construcció d'un relat històric als comtats de Besalú i de Barcelona, especialment per als segles xi-xii, a més de les estratègies matrimonials i del paper de les tres nissagues en la història local i general de Catalunya, així com l'origen de la figura del senescal.The aim of this paper is to study the ancestors of Guillem Galceran de Cartellà and his wife Blanca d'Hostoles with a detailed examination of the genealogical trees of the three main families: Hostoles, Cartellà and Creixell. This detailed analysis, and the compilation of all available documents, many of them previously unpublished, presented as a summary, helps to clarify many of the doubts regarding these genealogies, as well as providing useful material to construct the historical narrative of the counties of Besalú and Barcelona, especially for the 11th and 12th centuries, in addition to the matrimonial strategies employed and the role played by these three families in the local and general history of Catalonia, as well as the origins of the position of «seneschal» (steward)

Vocabularis

Onomàstic. Toponímic. Analític