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Observations related to chronologic and gynecologic age in pregnant adolescents.
A low chronologic age (less than or equal to 15 years) and low gynecologic age (less than or equal to 2 years) have been considered factors that increase medical complications among adolescent pregnant women. Gynecologic age (GA) is defined in this study as age in years at conception minus age at menarche. Two hundred twelve consecutive pregnant teenagers were followed prospectively in the Teen OB Clinic at the University of California, San Diego Medical Center, between August 1978 and July 1981. The clinic population consisted of 37.3 percent Whites, 35.8 percent Hispanics, 20.8 percent Blacks, and 6.1 percent other (mostly Indochinese). Sixty-eight percent of the patients were funded by MediCal. The patient population was divided by chronological age (CA) at conception into those 15 years or less or 16 years or older. A low chronological age was found to be a significant risk factor for premature rupture of membranes. Teenagers with a low gynecologic age (less than or equal to 2) had a lower mean pre-pregnancy weight and body mass index (Kg/M2) than teenagers with a higher gynecologic age. In this study, we did not find that a low CA or GA was correlated with a higher frequency of pregnancy-induced hypertension, prenatal medical problems, obstetrical problems at labor or delivery, or an excessive number of low-birthweight infants
Coz: Finding Code that Counts with Causal Profiling
Improving performance is a central concern for software developers. To locate
optimization opportunities, developers rely on software profilers. However,
these profilers only report where programs spent their time: optimizing that
code may have no impact on performance. Past profilers thus both waste
developer time and make it difficult for them to uncover significant
optimization opportunities.
This paper introduces causal profiling. Unlike past profiling approaches,
causal profiling indicates exactly where programmers should focus their
optimization efforts, and quantifies their potential impact. Causal profiling
works by running performance experiments during program execution. Each
experiment calculates the impact of any potential optimization by virtually
speeding up code: inserting pauses that slow down all other code running
concurrently. The key insight is that this slowdown has the same relative
effect as running that line faster, thus "virtually" speeding it up.
We present Coz, a causal profiler, which we evaluate on a range of
highly-tuned applications: Memcached, SQLite, and the PARSEC benchmark suite.
Coz identifies previously unknown optimization opportunities that are both
significant and targeted. Guided by Coz, we improve the performance of
Memcached by 9%, SQLite by 25%, and accelerate six PARSEC applications by as
much as 68%; in most cases, these optimizations involve modifying under 10
lines of code.Comment: Published at SOSP 2015 (Best Paper Award
Treatment and outcomes in necrotising autoimmune myopathy: an australian perspective
Necrotising Autoimmune Myopathy (NAM) presents as a subacute proximal myopathy with high creatine kinase levels. It is associated with statin exposure, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibody, connective tissue diseases, signal recognition particle (SRP) antibody and malignancy. This case series presents our Western Australian NAM patient cohort: comparing the subgroup presentations, biopsy appearance and treatment outcomes. We retrospectively collected data on patients diagnosed with NAM at the Western Australian Neuroscience Research Institute between the years 2000 and 2015. We identified 20 patients with Necrotising Autoimmune Myopathy: 14 with anti-HMGCR antibodies; two with anti-SRP antibodies; three with connective tissue disease; two as yet unspecified. Median creatine kinase level was 6047units/L (range 1000–17000). The statin naïve patients with HMGCR antibodies and patients with SRP antibodies were the most severely affected subgroups, with higher creatine kinase levels, and were more resistant to immunotherapy. Two or more immunotherapy agents were required in 90%; eight patients required IVIG and rituximab. Steroid weaning commonly precipitated relapses. Four patients had complete remission, and the remaining patients still require immunotherapy. Necrotising Autoimmune Myopathy is a potentially treatable myopathy, which can be precipitated by statin therapy and requires early, aggressive immunotherapy, usually requiring multiple steroid sparing agents for successful steroid weaning
Sleep disordered breathing and subclinical impairment of respiratory function are common in sporadic inclusion body myositis
Relatively little is known about frequency and extent of respiratory problems in sporadic inclusion body myositis (IBM). To address this issue a study of peripheral muscle and respiratory function and related symptoms was performed in a cohort with biopsy-proven IBM. Dyspnoea, daytime sleepiness, dysphagia, spirometry, respiratory muscle strength, arterial blood gas tensions and ventilation during sleep were assessed. Sixteen patients were studied (10 males; age 68.1 ± 9.9 years; disease duration 11.9 ± 5.0 years; body mass index 28.5 ± 4.0 kg/m2). Four reported excessive daytime sleepiness; 8 had at least mild dysphagia; forced vital capacity was <80% predicted normal in 7; sniff nasal inspiratory pressure was reduced in 3; daytime hypoxemia was present in 9 and hypercapnia in one. Sleep study was performed in 15 and revealed sleep disordered breathing (apnoea–hypopnoea index 23.4 ± 12.8 (range 7–50.3) events/h) in all. There were no consistent relationships between respiratory function impairment, occurrence of sleep disordered breathing, and severity of peripheral muscle weakness. Thus, asymptomatic impairment of respiratory function was common and sleep disordered breathing observed in all patients tested, irrespective of daytime respiratory function. This suggests respiratory function testing, including sleep study, should be performed routinely in IBM, irrespective of peripheral muscle function or other disease severity parameters
Rotational Evolution During Type I X-Ray Bursts
The rotation rates of six weakly-magnetic neutron stars accreting in low-mass
X-ray binaries have most likely been measured by Type I X-ray burst
observations with RXTE. The nearly coherent oscillations detected during the
few seconds of thermonuclear burning are most simply understood as rotational
modulation of brightness asymmetries on the neutron star surface. We show that,
as suggested by Strohmayer and colleagues, the frequency changes of 1-2 Hz
observed during bursts are consistent with angular momentum conservation as the
burning shell hydrostatically expands and contracts. We calculate how vertical
heat propagation through the radiative outer layers of the atmosphere and
convection affect the coherence of the oscillation. We show that the evolution
of the rotational profile depends strongly on whether the burning layers are
composed of pure helium or mixed hydrogen/helium. Our results help explain the
absence (presence) of oscillations from hydrogen-burning (helium-rich) bursts
that was found by Muno and collaborators.
We investigate angular momentum transport within the burning layers and the
recoupling of the burning layers with the star. We show that the
Kelvin-Helmholtz instability is quenched by the strong stratification, and that
mixing between the burning fuel and underlying ashes by the baroclinic
instability does not occur. However, the baroclinic instability may have time
to operate within the differentially rotating burning layer, potentially
bringing it into rigid rotation.Comment: To appear in The Astrophysical Journal; minor corrections made to
tables and figure
NMR-based Structural Studies of the Glycosylated MUC1 Tandem Repeat Peptide
MUC1 is a glycoprotein that plays an important role in cancer pathogenesis. In order to study the effect of glycosylation on the conformational propensities of the tandem repeat domain of MUC1, we have determined the structure of the MUC1 tandem repeat peptide AHGVTSAPDTRPAPGSTAPP, O-glycosylated with the trisaccharide (α-Glc-1,4-β-Glc-1,4-α-GalNAc-) at Thr5. This glycopeptide was synthesized to model a heavily Oglycosylated threonine residue in the tandem repeat domain. The NMR experiments used in this study included TOCSY, NOESY, ROESY, DQF-COSY, HSQC and 1D NMR. The peak volumes determined using the program SPARKY were converted into distance constraints using the program CALIBA. The programs FiSiNOE and HABAS were used to generate angle constraints. Using conformational restraints obtained from NMR, the program DYANA was used to determine the structures of the peptide. Finally, structural refinement was performed within the SYBYL software package using GLYCAM parameters and Kollman-all atom types. The presence of strong sequential αN connectivities suggested an extended conformation of the peptide backbone. Strong sequential αδ connectivities were indicative of a trans conformation of the Ala-Pro peptide bonds. In addition, presence of sequential NN connectivities in the peptide segments Gly3-Val4-Thr5-Ser6, Asp9-Thr10-Arg11 and Gly-Ser16 were indicative of twist-like conformations of the peptide backbone in these peptide segments
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