Reflection through Revision: A Master\u27s Portfolio

This document is a compilation of four essays centered around a theme of reflection and teaching English at a high school level. The essays include pedagogical research on reflective writing, teaching grammar, and standards-based grading in a junior high curriculum, as well as an analytical research essay on the role of the police in two contemporary domestic noir novels

Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels

Background: Osteogenesis imperfecta (OI) is characterized by bone fragility and short stature. Data about IGF-I/IGFBP-3 levels are rare in OI. Therefore IGF-I/IGFBP-3 levels in children with different types of OI were investigated. Methods: IGF-I and IGFBP-3 levels of 60 children (male n=38) were assessed in a retrospective cross-sectional setting. Results: Height/weight was significant different [height z-score type 3 versus type 4: p=0.0011 and weight (p <= 0.0001)] between OI type 3 and 4. Mean IGF-I levels were in the lower normal range (mean +/- SD level 137.4 +/- 109.1 mu g/L). Mean IGFBP-3 measurements were in the normal range (mean +/- SD 3.105 +/- 1.175 mg/L). No significant differences between OI type 3 and 4 children have been observed (IGF-I: p=0.0906; IGFBP-3: p=0.2042). Conclusions: Patients with different severities of OI have IGF-I and IGFBP-3 levels in the lower normal range. The type of OI does not significantly influence these growth factors