Thermal history of the early Miocene Waitemata Basin and adjacent Waipapa Group, North Island, New Zealand

Apatite fission track (AFT) and vitrinite reflectance (VR) data for early Miocene outcrops from the Waitemata Basin reveal that the basin sequence was subjected to shallow burial before denudation. AFT results suggest that the total sediment thickness within the basin was <=1 km and maximum paleotemperatures during burial never exceeded c. 60deg.C. Statistical analyses of the detrital AFT ages distinguish four dominant sources of sediment supply: contemporaneous volcanism; metagreywacke rocks of the Waipapa Group; the Northland Allochthon; and an unidentified source south of the basin. The apatite and zircon fission track results from the Waipapa Group rocks (Gondwana Terrane) adjacent to the basin suggest two discrete phases of accelerated cooling: the first during the early Cretaceous (c. 117 Ma) and the second during the mid Cretaceous (c. 84 Ma). These events probably reflect key stages in the tectonic development of the New Zealand microcontinent during the Cretaceous period, the earlier event being related to the climax of compressional deformation (Rangitata Orogeny) and the latter to extensional tectonism associated with the opening of the Tasman Sea. Waipapa Group rocks now exposed at the surface cooled from maximum paleotemperatures of c. 250deg.C at an estimated rate of c. 180-36deg.C/m.y., involving substantial denudation

Research Training in Explicitly Christian Doctoral Programs

The importance of research training at explicitly Christian doctoral programs is suggested on the basis of four reasons: the need to hold science and practice together, the need for skills to evaluate interventions, the need to serve a society with a growing interest in religion and spirituality, and the need to assess the effectiveness of explicitly Christian doctoral programs. A discussion of these issues serves as an introduction to the rest of this special issue that focuses on research training at seven explicitly Christian programs

Clinical Training in Explicitly Christian Doctoral Programs: Introduction to the Special Issue

This article serves as a brief introduction to this special journal issue on clinical training in doctoral psychology programs described as explicitly Christian. Seven doctoral programs are described by their respective Directors of Clinical Training (DCT) in this special issue. In this introductory paper, we identify four common themes found across the program descriptions: 1) the enthusiasm for respective training missions, 2) the transformation observed in students, 3) the intentional progression of training, and 4) the varied meanings of the term integration

What are the most effective interventions to reduce childhood obesity?

Efforts to increase physical activity or decrease sedentary activities have shown some short-term benefit, and adding dietary changes may be more effective. Aiming interventions at parents, intensive family therapy, comprehensive school-based programs, and selecting motivated children for subspecialty care may improve success. (Grade of recommendation: B, based on poor-quality randomized controlled trials [RCTs] and heterogeneous systematic reviews.) Other potentially effective short-term strategies include screening with body mass index (BMI) for age (grade of recommendation: C, extrapolation from cohort studies and ecological research) or dietary counseling (grade of recommendation: D, conflicting poor-quality RCTs). No drugs are currently approved for pediatric obesity therapy in the United States

Satisfaction with Research Training in Christian Psychology Doctoral Programs: Survey Findings and Implications

Perceptions of research training at seven explicitly Christian doctoral programs in clinical psychology were assessed with a satisfaction survey. A total of 283 students, 98 alumni, and 51 faculty completed the online questionnaire. Perceived strengths include faculty-student collaboration, encouraging students to present at national meetings, respect for faculty, and effective curricula. Areas for future growth include enhanced research funding, making research mentoring available to all students, and decreasing the perceived dichotomy between clinical and research competence. Self-reported faculty and student publication and presentation rates are also presented and discussed

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention

Time course of morphological alterations of fungiform papillae and taste buds following chorda tympani transection in neonatal rats

The time course of structural changes in fungiform papillae was analyzed in rats that received unilateral chorda tympani nerve transection at 10 days of age. Morphological differences between intact and denervated sides of the tongue were first observed at 8 days postsection, with an increase in the number of fungiform papillae that did not have a pore. In addition, the first papilla with a filiform‐like appearance was noted on the denervated side at 8 days postsectioning. By 11 days after surgery, the total number of papillae and the number of papillae with a pore were significantly lower on the transected side of the tongue as compared to the intact side. At 50 days postsection, there was an average of 70.5 fungiform papillae on the intact side and a mean of only 20.8 fungiform papillae the denervated side. Of those few remaining papillae on the cut side, an average of 13.5 papillae were categorized as filiform‐like, while no filiform‐like papillae occurred on the intact side. Significant reduction in taste bud volume was noted at 4 days posttransection and further decrements in taste bud volume were noted at 8 and 30 days postsection. Electron microscopy of the lingual branch of the trigeminal nerve from adult rats that received neonatal chorda tympani transection showed normal numbers of both myelinated and unmyelinated fibers. Thus, in addition to the well‐characterized dependence of taste bud maintenance on the chorda tympani nerve, the present study shows an additional role of the chorda tympani nerve in papilla maintenance during early postnatal development. © 2002 Wiley Periodicals, Inc. J Neurobiol 51: 223–236, 2002

Positive Reappraisals After an Offense: Event-related Potentials and Emotional Effects of Benefit-finding and Compassion

Using a within subjects design, three emotion regulation strategies (compassion‐focused reappraisal, benefit‐focused reappraisal, and offense rumination) were tested for their effects on forgiveness, well‐being, and event‐related potentials (ERPs). Participants (N = 37) recalled a recent interpersonal offense as the context for each emotion regulation strategy. Both decisional and emotional forgiveness increased significantly for the two reappraisal strategies compared to offense rumination. Compassion‐focused reappraisal prompted the greatest increase in both decisional and emotional forgiveness. Furthermore, both reappraisal strategies increased positively oriented well‐being measures (e.g., joy, gratitude) compared to offense rumination, with compassion‐focused reappraisal demonstrating the largest effect on empathy. Late positive potential (LPP) amplitudes in response to unpleasant affect words were larger following the benefit‐focused reappraisal strategy, indicating frontal LPP augmentation due to affective incongruence of the unpleasant stimuli with the positive, silver‐lining orientation of the benefit‐focused reappraisal emotion regulation strategy

Preventive measures in infancy to reduce under-five mortality: a case-control study in The Gambia.

OBJECTIVE: To investigate the relationship between child mortality and common preventive interventions: vaccination, trained birthing attendants, tetanus toxoid during pregnancy, breastfeeding and vitamin A supplementation. METHODS: Case-control study in a population under demographic surveillance. Cases (n = 141) were children under five who died. Each was age and sex-matched to five controls (n = 705). Information was gathered by interviewing primary caregivers. RESULTS: All but one of the interventions - whether the mother had received tetanus toxoid during pregnancy - were protective against child mortality after multivariate analysis. Having a trained person assisting at child birth (OR 0.2 95% CI 0.1-0.4), receiving all vaccinations by 9 months of age (OR 0.1; 95% CI 0.01-0.3), being breastfed for more than 12 months (Children breastfed between 13 and 24 months OR 0.1 95% CI 0.03-0.3, more than 25 months OR 0.1 95% CI 0.01-0.5) and receiving vitamin A supplementation at or after 6 months of age (OR 0.05; 95% CI 0.01-0.2) were protective against child death. CONCLUSIONS: This study confirms the value of at least four available interventions in the prevention of under-five death in The Gambia. It is now important to identify those who are not receiving them and why, and to intervene to improve coverage across the population