31 research outputs found
PirB regulates asymmetries in hippocampal circuitry
Left-right asymmetry is a fundamental feature of higher-order brain structure; however, the molecular basis of brain asymmetry remains unclear. We recently identified structural and functional asymmetries in mouse hippocampal circuitry that result from the asymmetrical distribution of two distinct populations of pyramidal cell synapses that differ in the density of the NMDA receptor subunit GluRε2 (also known as NR2B, GRIN2B or GluN2B). By examining the synaptic distribution of ε2 subunits, we previously found that β2-microglobulin-deficient mice, which lack cell surface expression of the vast majority of major histocompatibility complex class I (MHCI) proteins, do not exhibit circuit asymmetry. In the present study, we conducted electrophysiological and anatomical analyses on the hippocampal circuitry of mice with a knockout of the paired immunoglobulin-like receptor B (PirB), an MHCI receptor. As in β2-microglobulin-deficient mice, the PirB-deficient hippocampus lacked circuit asymmetries. This finding that MHCI loss-of-function mice and PirB knockout mice have identical phenotypes suggests that MHCI signals that produce hippocampal asymmetries are transduced through PirB. Our results provide evidence for a critical role of the MHCI/PirB signaling system in the generation of asymmetries in hippocampal circuitry
Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice
Leaf water δ18O and leaf temperature monitoring during 2014-07-24 to 2014-07-26 at Spasskaya Pad in northeastern Siberia
Meteorological data, soil amount, and the data of δ18O values of soil water, stem water, and tree ring cellulose in 20 years at Spasskaya Pad in eastern Siberia
The supporting data for the manuscript "Oxygen Isotope Compositions of Cellulose in Earlywood of Larix cajanderi Determined by Water Source Rather Than Leaf Water Enrichment in a Permafrost Ecosystem, Eastern Siberia". The data set includes relating meteorological data (i.e., temperature and precipitation from 1979 to 2015, and relative humidity from 2000 to 2016), soil amount from 1998 to 2015, and the data of δ18O values. The δ18O values' data include soil water from 1998 to 2015, stem water from 1997 to 2015, tree ring cellulose from 1981 to 2016, and daily monitoring of leaf water in 2014 and 2015