2 research outputs found
Nationwide surveillance of Streptococcus pneumoniae in Greece: patterns of resistance and serotype epidemiology
This nationwide study assessed the antimicrobial susceptibility and
seroprevalence of Streptococcus pneumonicae in paediatric carriage
isolates and in clinical isolates from adult pneumococcal disease in
Greece during the years 2004-2006. Among 780 isolates recovered from the
nasopharynx of children < 6 years old attending day-care centres,
non-susceptibility rates to penicillin, cefuroxime, ceftriaxone,
erythromycin, tetracycline and trimethoprim/sulfamethoxazole were
34.7%, 25.1%1.0%, 33.5%, 26.4% and 44.2%, respectively. Among 89
adult clinical isolates, the respective rates were 48.3%, 46.1%,
5.6%, 48.3%, 32.6% and 40.4%. High-level resistance to penicillin,
cefuroxime and ceftriaxone was recorded for 14.4%, 23.3% and 0.1 % of
paediatric carriage isolates, whereas for clinical adult isolates the
respective rates were 25.8%, 38.2% and 2.2%. No resistance to
levofloxacin and moxifloxacin was recorded, although 3.5% of paediatric
carriage isolates and 23.2% of adult clinical isolates had minimum
inhibitory concentrations of ciprofloxacin > 2 mg/L. Serotypes 19F, 14,
23F and 6B were the most prevalent among carriage and clinical isolates.
The 7-valent pneumococcal conjugate vaccine was estimated to provide
coverage against 71.7% of paediatric carriage isolates and 51.3% of
adult clinical isolates. Resistance rates among clinical isolates from
adult sources were higher than those recorded among paediatric carriage
S. pneumoniae isolates and displayed an increasingly resistant profile
compared with previous reports from our country, warranting continuous
vigilance. (c) 2007 Elsevier B.V. and the International society of
Chemotherapy. All rights reserved