The impact of residential experiences on pupil progress and attainment in year six (10-11 year olds) in England: a Learning Away comparative research study

The comparative study in this design focusses on examining the provisional findings for the impact of residentials on progress and attainment indicated in previous research findings and the Learning Away evaluation report (Kendall & Rodger, 2015). This study was funded by a grant from the Paul Hamlyn Foundation to the Learning Away Consortium of the Council for Learning Outside the Classroom. It was undertaken in partnership with the residential provider, the Brathay Trust, and a Local Authority. The research took place with eight primary schools in the academic year 2017-2018

Research hubs: the theory-practice nexus

Outdoor learning aims to support the raising of standards by bringing researchers and practitioners closer together. A number of strategies have proved effective including the development of strong networks between researchers and practitioners, local action research hubs, participative enquiry and the development of practitioner researchers. Two recent projects in schools have been successful at using action research approaches to support professional development leading to increased take up and raised standards of their respective pedagogies. Regional Outdoor Learning research hubs have been designed and piloted. The impact that research conducted in these ways is evaluated to inform future practice

The impact of residential experiences on pupils’ cognitive and non-cognitive development in year six (10 – 11 year olds) in England

Using a comparative mixed methods approach, this study examines the impact of residential experiences on pupil cognitive and non-cognitive development in year six in England. SAT’s results and termly progress data in numeracy and literacy were collected. In addition, a ROPELOC survey, focus groups and interviews were used to assess non-cognitive outcomes. Progress and attainment data were found to be invalid for the purposes of this study partly due to the coarseness of the categories. The ROPELOC survey evidenced significant impact of the residentials in all but two of the fifteen categories and highly significant impact in seven areas. The findings add further support to the Learning Away learning pathway linking a range of non-cognitive outcomes developed through residential experiences with cognitive gains

BioSimSpace: An interoperable Python framework for biomolecular simulation

BioSimSpace is an interoperable Python framework for biomolecular simulation. With it you can: Write robust and portable biomolecular workflow components that work on different hardware, with different software packages, and that can be run in different ways, e.g. command-line, Jupyter. Interact with molecular-simulation processes in real time

Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder characterized by progressive muscular weakness due to the selective loss of motor neurons. Mutations in the gene Fused in Sarcoma (FUS) were identified as one cause of ALS. Here, we report that mutations in FUS lead to upregulation of synaptic proteins, increasing synaptic activity and abnormal release of vesicles at the synaptic cleft. Consequently, FUS-ALS neurons showed greater vulnerability to glutamate excitotoxicity, which raised neuronal swellings (varicose neurites) and led to neuronal death. Fragile X mental retardation protein (FMRP) is an RNA-binding protein known to regulate synaptic protein translation, and its expression is reduced in the FUS-ALS lines. Collectively, our data suggest that a reduction of FMRP levels alters the synaptic protein dynamics, leading to synaptic dysfunction and glutamate excitotoxicity. Here, we present a mechanistic hypothesis linking dysregulation of peripheral translation with synaptic vulnerability in the pathogenesis of FUS-ALS.</p

Discovery of sarolaner:A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs

AbstractThe novel isoxazoline ectoparasiticide, sarolaner, was identified during a lead optimization program for an orally-active compound with efficacy against fleas and ticks on dogs. The aim of the discovery program was to identify a novel isoxazoline specifically for use in companion animals, beginning with de novo synthesis in the Zoetis research laboratories. The sarolaner molecule has unique structural features important for its potency and pharmacokinetic (PK) properties, including spiroazetidine and sulfone moieties. The flea and tick activity resides in the chirally pure S-enantiomer, which was purified to alleviate potential off-target effects from the inactive enantiomer. The mechanism of action was established in electrophysiology assays using CHO-K1 cell lines stably expressing cat flea (Ctenocephalides felis) RDL (resistance-to-dieldrin) genes for assessment of GABA-gated chloride channel (GABACls) pharmacology. As expected, sarolaner inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with similar potency. Initial whole organism screening was conducted in vitro using a blood feeding assay against C. felis. Compounds which demonstrated robust activity in the flea feed assay were subsequently tested in an in vitro ingestion assay against the soft tick, Ornithodoros turicata. Efficacious compounds which were confirmed safe in rodents at doses up to 30mg/kg were progressed to safety, PK and efficacy studies in dogs. In vitro sarolaner demonstrated an LC80 of 0.3μg/mL against C. felis and an LC100 of 0.003μg/mL against O. turicata. In a head-to-head comparative in vitro assay with both afoxolaner and fluralaner, sarolaner demonstrated superior flea and tick potency. In exploratory safety studies in dogs, sarolaner demonstrated safety in dogs≥8 weeks of age upon repeated monthly dosing at up to 20mg/kg. Sarolaner was rapidly and well absorbed following oral dosing. Time to maximum plasma concentration occurred within the first day post-dose. Bioavailability for sarolaner was calculated at >85% and the compound was highly protein bound (>99.9%). The half-life for sarolaner was calculated at 11–12 days. Sarolaner plasma concentrations indicated dose proportionality over the range 1.25–5mg/kg, and these same doses provided robust efficacy (>99%) for ≥35days against both fleas (C. felis) and multiple species of ticks (Rhipicephalus sanguineus, Ixodes ricinus and Dermacentor reticulatus) after oral administration to dogs. As a result of these exploratory investigations, sarolaner was progressed for development as an oral monthly dose for treatment and control of fleas and ticks on dogs

Magneto-optical trapping in a near-surface borehole

Borehole gravity sensing can be used in a number of applications to measure features around a well including rock-type change mapping and determination of reservoir porosity. Quantum technology gravity sensors based on atom interferometry have the ability to offer increased survey speeds and reduced need for calibration. While surface sensors have been demonstrated in real world environments, significant improvements in robustness and reductions to radial size, weight, and power consumption are required for such devices to be deployed in boreholes. To realise the first step towards the deployment of cold atom-based sensors down boreholes, we demonstrate a borehole-deployable magneto-optical trap, the core package of many cold atom-based systems. The enclosure containing the magneto-optical trap itself had an outer radius of ($60\pm0.1$) mm at its widest point and a length of ($890\pm5$) mm. This system was used to generate atom clouds at 1 m intervals in a 14 cm wide, 50 m deep borehole, to simulate an in-borehole gravity surveys are performed. During the survey the system generated on average clouds of (3.0 $\pm 0.1) \times 10^{5}$ $^{87}$Rb atoms with the standard deviation in atom number across the survey observed to be as low as $9 \times 10^{4}$

Magneto-optical trapping in a near-suface borehole

Borehole gravity sensing can be used in a number of applications to measure features around a well, including rock-type change mapping and determination of reservoir porosity. Quantum technology gravity sensors, based on atom interferometry, have the ability to offer increased survey speeds and reduced need for calibration. While surface sensors have been demonstrated in real world environments, significant improvements in robustness and reductions to radial size, weight, and power consumption are required for such devices to be deployed in boreholes. To realise the first step towards the deployment of cold atom-based sensors down boreholes, we demonstrate a borehole-deployable magneto-optical trap, the core package of many cold atom-based systems. The enclosure containing the magneto-optical trap itself had an outer radius of (60 ± 0.1) mm at its widest point and a length of (890 ± 5) mm. This system was used to generate atom clouds at 1 m intervals in a 14 cm wide, 50 m deep borehole, to simulate how in-borehole gravity surveys are performed. During the survey, the system generated, on average, clouds of (3.0 ± 0.1) × 105 87Rb atoms with the standard deviation in atom number across the survey observed to be as low as 8.9 × 104