Hepatic and Renal Function Tests and Routine Hematological Markers in Patients with Cerebrovascular Accident and Transient Ischemic Attack

Background and Aim: Cerebrovascular accident (CVA), also known as stroke, is a vascular syndrome that is the second leading cause of death in the world after ischemic heart disease. Transient ischemic attacks (TIAs) is a warning sign for CVA so that 20% of patients with TIA experience a subsequent stroke within 90 days. Hence, identification of laboratory markers is crucial for the prognosis and diagnosis of patients with CVA and TIA. Changes in some laboratory markers occur in patients with CVA and TIA. Thus, the present study aimed to evaluate hepatic and renal function tests and routine hematological markers in patients with CVA and TIA. Methods: The present study was a cross - sectional analytical study. The study population was patients with CVA and TIA who were hospitalized in Abadan and Khorramshahr educational hospitals from March 21, 2019, to March 19, 2020. One hundred patients with CVA and one hundred patients with TIA were randomly selected and the necessary information (age, sex, liver enzymes, renal function tests, FBS, and routing hematologic markers including CBC, ESR, PT and PTT) of the patients was collected from HIS (Hospital Information System) of Abadan and Khorramshahr educational hospitals. Liver, kidney and hematologic diagnostic markers were evaluated by age and gender. Data analysis was performed using a t -test (to compare gender difference of laboratory markers in CVA and TIA groups) and one-way ANOVA (to compare laboratory markers among age groups of patients with CVA and TIA). Simple linear regression was used to examine the relationships between changes in FBS (mg / dl) and changes in laboratory diagnostic factors. Results: The results of this study showed that the highest frequency of patients with CVA (n= 130, 27.3%) and TIA (n= 49, 23.8%) was observed in the age group of 55-64 years. The results indicate that the mean level of some laboratory markers such as FBS (CVA: 174.32 ± 105.83; TIA: 150.32 ± 83.32), creatinine (CVA: 1.37 ± 1.32; 1.42 ± 1.09), LDH (CVA: 696.29 ± 344.90; TIA: 538.17 ± 230.76), and ESR (CVA: 52.41 ± 37.61; TIA: 14.00 ± 8.40) was higher than the normal range in both CVA and TIA. The mean of SGOT (34.10 ± 26.40 IU / L) and ALK (331.44 ± 370.78 IU / L) enzymes were higher than normal only in CVA patients and the mean of SGPT (33.08 ± 38.55 IU / L) was higher than normal only in TIA patients. It was also observed that in patients with CVA, with each unit increase in FBS, a significant increase occurs in K+ level (P < 0.001), WBC (P= 0.003), and RBC (P= 0.031) count, as well as a significant decrease in Na+ level (P= 0.008). Conclusion: The results of the present study showed an increase in the level of FBS, ESR and LDH both in CVA and TIA. While SGOT and ALK increased only in CVA patients, SGPT showed an increase only in TIA patients.   *First Corresponding Author: Esmat Radmanesh; Email: [email protected]; ORCID ID:                                        0000-0003-1369-6580 Second Corresponding Author: Sahar Golabi; Email: [email protected] Please cite this article as:  Monfared A, Fadavipour M, Golabi S, Kamyari N, Zahedi A, Hazbenejad A, Kanani K, Jelvay S, Tajvidi M, Radmanesh E. Hepatic and Renal Function Tests and Routine Hematological Markers in Patients with Cerebrovascular Accident and Transient Ischemic Attack. Arch Med Lab Sci. 2023;9:1-9 (e3). https://doi.org/10.22037/amls.v9.3925

Evaluation of laboratory diagnostic markers in patients with hypertension

Background: Hypertension is growing as a global public health problem. It is one of the most important risk factors for various diseases including cardiovascular disease. The study of laboratory markers and early detection of complications can play an effective role in controlling the disease. Objectives: The present study was performed to determine renal, hepatic, and blood markers in patients with hypertension in Abadan and Khorramshahr educational hospitals. Materials and Methods: The present study was a descriptive-analytical cross-sectional study that was performed from March 21, 2020, to March 19, 2021, on patients with hypertension referred to Abadan and Khorramshahr educational hospitals. Information on age, sex, and laboratory diagnostic factors of patients with hypertension admitted to HIS were received. Data were analyzed using STATA software. Results: The study population was 1505 patients with hypertension admitted to Abadan and Khorramshahr educational hospitals (487 male (32%) and 1018 were females (68%). The average age of the patients was 61 (SD: 12). The highest frequency of patients with hypertension was in the age group of 64-55 years with a frequency of 420 (27.9%). The results showed that the mean of creatinine was higher than normal. The mean of CK-MB and INR was slightly higher than normal. The two sexes were significantly different from the mean of CK-MB, AST, ALT, Cr, Na, MCHC, HCT, HB, and RBC. According to the unadjusted and multiple logistic regression analysis, Each 1 unit increase in BUN and K+ was associated with an increase in the odds of abnormal creatinine. Each 1 unit increase in RBC, HB, HCT, MCH, and MCHC was associated with a decrease in the odds of abnormal creatinine, and Each 1 unit increase in PT was associated with an increase in the odds of abnormal creatinine. Conclusions: The results of the present study showed that some laboratory markers in patients with hypertension were above the normal range including renal, cardiac, and coagulation diagnostic factors and some of it depends on age and sex, so it is important to pay attention to these markers in controlling high blood pressure in these patients, however, further studies in this field are recommended. &nbsp