Burkitt’s Lymphoma: a Rare Sporadic Case

U radu je opisan slučaj devetogodišnjega dječaka s multilokularnim lezijama u objema čeljustima, uz prisutnu facijalnu asimetriju ekstraoralno te intraoralan nalaz zamjetnih gingivalnih lezija s fiksiranim oteklinama na lijevoj, te dijelovima desne strane i mandibule i maksile. Radiografske pretrage uključivale su i panoramsku rendgensku snimku na kojoj se vidi tek lagana radiolucentnost u lijevoj premolarnoj i molarnoj regiji mandibule. Incizijska biopsija obavljena je na gingivalnim masama te je histopatološka analiza potvrdila BL. Liječenje se nije moglo završiti, jer se s time nisu složili pacijentovi neškolovani roditelji iz skupine stanovništva niskoga društvenog položaja. Pacijent je umro osam mjeseci nakon što mu je bila postavljena dijagnoza. U ovom smo predstavljanju kliničkoga slučaja nastojali opisati rijedak i povremen slučaj BL-a koji je zahvaćao četiri čeljusna segmenta, što je inače obilježje endemskog oblika BL-a, te smo željeli istaknuti značenje suradnje između liječnika i pacijenta ili njegovih skrbnika.We report a case of a 9 year-old boy who had multilocular lesions in both of his jaws. There was extraoral facial asymmetry and intraoral examination revealed remarkable gingival lesions with fixed swellings on the left and right parts of both maxilla and mandible. Radiographic examination included panoramic radiograph showing only a slight radiolucency in the left premolar and molar region of mandible. Incisional biopsy of the gingival masses was performed and histopathologic examination disclosed BL. The treatment could not be completed due to the disagreement of patient’s parents who were uneducated and had a low social status. The patient died within 8 months after the diagnosis. In this report we aimed to present a rare sporadic case of BL with a four segmental involvement of the jaws which is usually seen in endemic type of BL as well as emphasize the significance of the cooperation between physicians and patients

The roles of matrix metalloproteinases-2,-7,-10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus

J Oral Pathol Med (2012) 41: 689696 Background: The aim of this study was to investigate the roles of Matrix Metalloproteinases (MMP)-2, Metalloproteinases-7, Metalloproteinases-10 and Tissue Inhibitors of Metalloproteinase-1 (TIMP-1) in the pathogenesis of oral lichen planus (OLP) disease in same tissue samples. Methods: Thirty-nine individuals [29 patients with OLP (74%) and 10 healthy control subjects (25%)] were included in our study. The mean age was 48 +/- 14.39 with a range of 2075. Results: MMP-2 and MMP-7 expression was significantly different in the patient and control groups in the epithelium and the connective tissue (P < 0. 05). The ratio of MMP-2/TIMP-1 and MMP-7/TIMP-1 were higher in patient with OLP group than control group. Conclusions: Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP-2, MMP-7, and TIMP-1 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP