SensorShoe: Mobile Gait Analysis for Parkinson's Disease Patients

We present the design and initial evaluation of a mobile gait analysis system, SensorShoe. The target user group is represented by Parkinson's Disease patients, which need continuous assistance with the physical therapy in their home environment. SensorShoe analyses the gait by using a low-power sensor node equipped with movement sensors. In addition, SensorShoe gives real-time feedback and therapy assistance to the patient, and provides the caregivers an effective remote monitoring and control tool

Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1

The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL) formation and considered rate-controlling for reverse cholesterol transport. Expression of the Abca1 gene is under control of the liver X receptor (LXR). We have evaluated effects of LXR activation by the synthetic agonist T0901317 on hepatic and intestinal cholesterol metabolism in C57BL/6J and DBA/1 wild-type mice and in ABCA1-deficient DBA/1 mice. In wild-type mice, T0901317 increased expression of Abca1 in liver and intestine, which was associated with a similar to60% rise in HDL. Biliary cholesterol excretion rose 2.7-fold upon treatment, and fecal neutral sterol output was increased by 150-300%. Plasma cholesterol levels also increased in treated Abca1(-/-) mice (+120%), but exclusively in very low density lipoprotein-sized fractions. Despite the absence of HDL, hepatobiliary cholesterol output was stimulated upon LXR activation in Abca1(-/-) mice, leading to a 250% increase in the biliary cholesterol/phospholipid ratio. Most importantly, fecal neutral sterol loss was induced to a similar extent (+300%) by the LXR agonist in DBA/1 wild-type and Abca1(-/-) mice. Expression of Abcg5 and Abcg8, recently implicated in biliary excretion of cholesterol and its intestinal absorption, was induced in T0901317-treated mice. Thus, activation of LXR in mice leads to enhanced hepatobiliary cholesterol secretion and fecal neutral sterol loss independent of (ABCA1-mediated) elevation of HDL and the presence of ABCA1 in liver and intestine

Teacher perspectives on the introduction of linguistics in the languages classroom. Evidence from a co-creation project on French, German and Spanish

Linguistics is conspicuously absent from language teaching in UK schools. A-level cultural topics cover a range of themes such as cyber-society, cultural heritage and multiculturalism, but the approach taken to these topics is not informed by linguistics. In previous work, we have argued that this is an unfortunate omission not only because linguistics is appealing to many language students and perceived by them to be useful, but also because the existing cultural topics could be significantly enriched by the inclusion of the critical/analytical study of language itself. In this paper, we provide concrete examples of how linguistics can be integrated into the existing A-level curriculum for Modern Foreign Languages (MFL) in England and Wales. Reporting on a project in which teachers trialled linguistics materials co-created by us (a group of academics) and experienced languages teachers, we present evidence that linguistics materials are perceived to be both highly novel and nonetheless compatible with the existing A-level curriculum. Data from questionnaires and semi-structured interviews with participating teachers also show that: (i) these new materials can be taught with little or no prior experience of linguistics; and (ii) adding linguistics materials to the curriculum leads to significant impacts on teacher and pupil attitudes towards language(s). Despite some challenges, which we also discuss, the results highlight again the great potential of linguistics as a component of language teaching and the contribution that it can make to the enrichment of the discipline. (DIPF/Orig.

Adaptive process control strategy for a two-step bending process

A robust production is an important goal in sheet metal forming in order to make the process outcome insensitive to variations in input and process conditions. This would guarantee a minimum number of defects and reduced press downtime. However, for com-plex parts it is difficult to achieve robust settings. Parts without defects can only be real-ized if the process parameters are adapted to the changed conditions.\ud In this paper, an approach for adaptive process control is presented, taking the uncertain-ties and tolerances of the process and material into consideration. The proposed control approach combines feedback and feed-forward control strategies. The most significant improvement is to incorporate feed-forward control with knowledge about the system (also known as predictive models). To create these models high fidelity numerical models have been created. Furthermore, a procedure is presented to update the coefficients of the predictive model to adapt it to the actual process state.\ud To evaluate the control strategy prior to its implementation, a testing environment has been developed. Different test scenarios for common states of the process have been generated to evaluate the improvement of the proposed control strategy