29 research outputs found
Severe antibody-mediated transfusion-related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non-transfused male blood donor
TransfusionâRelated Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of lifeâthreatening TRALI in an obstetric patient triggered by transfusion from a nonâtransfused male blood donor. A residual risk of TRALI exist, even in a maleâonly plasma setting
Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients
ABO, secretor, and Lewis carbohydrate histo-blood groups are associated with autoimmune neutropenia of early childhood in Danish patients
BACKGROUND: Autoimmune neutropenia of early childhood (AIN) is caused by autoantibodies directed against antigens on the neutrophil membrane. The ABO, secretor, and Lewis histoâblood group systems control the expression of carbohydrate antigens and have previously been linked to autoimmune diseases. We aimed to investigate the association between genotypes and the risk of AIN in Danish patients. STUDY DESIGN AND METHODS: One hundred fiftyâfour antibodyâpositive AIN patients were included. Controls (n = 400) were healthy unrelated Danish blood donors. Molecular determination of ABO, secretor (FUT2), and Lewis (FUT3) genotypes were determined using realâtime polymerase chain reaction (qPCR) or Sanger sequencing to infer the prevalence of Lewis antigens (Le(a) and Le(b)) and secretor (SeSe or Sese) or nonsecretor (sese) phenotypes. RESULTS: Blood type O was more common in controls (46.8%) than in AIN patients (36.4%) (OR = 0.65; p = 0.028). Secretors of H Le(b) antigens were less frequent among AIN patients (25.2%) than controls (35.0%) (OR = 0.62; p = 0.037). DISCUSSION: ABO blood group antigens and the secretion of these antigens are associated with a diagnosis of AIN. The mechanism underlying the association between autoimmunity and interaction among ABO, secretor, and Lewis genotypes has not yet been elucidated, but several studies indicate a connection to the gut microbiota
HNA specificity and association to <i>HLA-DRB1</i> and <i>-DQB1</i> in patients with autoimmune neutropenia of early childhood
Potential pitfalls in genotyping of FCGR3B deficient individuals
The steel beams and girders are being put in place for the new Owens-Corning Fiberglas Tower on the corner of St. Clair Street and Madison Avenue in Downtown Toledo. The Owens-Illinois Building can be seen in the background. Terms associated with the photograph are: Fiberglas Tower (Toledo, Ohio) | Owens-Corning (Toledo, Ohio) | buildings - design and construction | cranes | Owens-Illinois Building (Toledo, Ohio) | Summit Street (Toledo, Ohio) | Madison Avenue (Toledo, Ohio) | 200 North Saint Clair Street (Toledo, Ohio
Severe antibodyâmediated transfusionârelated acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a nonâtransfused male blood donor
TransfusionâRelated Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of lifeâthreatening TRALI in an obstetric patient triggered by transfusion from a nonâtransfused male blood donor. A residual risk of TRALI exist, even in a maleâonly plasma setting