International Migration, Remittances and its Macroeconomic Impact on Indian Economy

This paper tried to study the impact of remittances on various macroeconomic and developmental aspects for the Indian economy. For this, the data regarding remittances and some of the macroeconomic variables like GDP, PFCE, GDFC, savings, FDI, FII, export, import and balance of trade deficit etc have been analyzed for the period 1971-2008. The study shows that remittances have been consistently increasing at very fast rate for the last 15 years which have significant implications on the above mentioned macroeconomic variables. Through this study, the importance of remittances as a source of external development finance has been discussed. At last, some of the regulatory frameworks governing the flow of remittances have also been discussed.

Kerala's gulf connection : emigration, remittances and their macroeconomic impact, 1972-2000

This paper attempts to construct a time series estimation of remittances from abroad to the Kerala economy for the period 1972 to 2000. It is now widely acknowledged that foreign remittances in the economy of the State of Kerala in India in the form of money sent by its workers in the Gulf countries play a crucial role. The study finds that by the early nineties remittances to the Kerala economy assumed a significant share of state income. This ranged from 17 percent during 1991-92 and 24 percent during 1997-98 with an average of 22 percent for the second half of the nineties. The liberalisation of the Indian economic policies, particularly the foreign exchange rate, benefited Kerala directly. Adding the remittance income to the Net State Domestic Product, a Modified State Income series has been constructed. As a result Kerala’s per capita income not only caught up with the average per capita income for India but started exceeding it reaching 49 percent above the national average by the end of the nineties. This tallies with per capita consumer expenditure in Kerala, which was in excess of 41 percent above the national average by the end of the nineties. Remittances have also made significant impact on savings. By the nineties savings rates in the Kerala economy seem to have reached such high levels comparable to the East and South East Asian countries. The significance of remittances can also be gauged by its relative magnitudes. By the end of the nineties remittances reached such levels that they were well above the total government expenditure, value added in manufacturing and even the value added in industrial sector as a whole. JEL Classification: F22, J61 Key Words: emigration, Gulf countries, Kerala economy, remittances, and consumption

Delayed mucosal antiviral responses despite robust peripheral inflammation in fatal COVID-19

Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished coronavirus disease 2019 (COVID-19) severity categories, and relate these to disease progression and peripheral inflammation. Methods We measured 35 cytokines and chemokines in nasal samples from 274 patients hospitalized with COVID-19. Analysis considered the timing of sampling during disease, as either the early (0–5 days after symptom onset) or late (6–20 days after symptom onset) phase. Results Patients that survived severe COVID-19 showed interferon (IFN)-dominated mucosal immune responses (IFN-γ, CXCL10, and CXCL13) early in infection. These early mucosal responses were absent in patients who would progress to fatal disease despite equivalent SARS-CoV-2 viral load. Mucosal inflammation in later disease was dominated by interleukin 2 (IL-2), IL-10, IFN-γ, and IL-12p70, which scaled with severity but did not differentiate patients who would survive or succumb to disease. Cytokines and chemokines in the mucosa showed distinctions from responses evident in the peripheral blood, particularly during fatal disease. Conclusions Defective early mucosal antiviral responses anticipate fatal COVID-19 but are not associated with viral load. Early mucosal immune responses may define the trajectory of severe COVID-19

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials

Kerala's Gulf connection: Emigration, remittances and their macroeconomic impact 1972-2000

This paper attempts to construct a time series estimation of remittances from abroad to the Kerala economy for the period 1972 to 2000. It is now widely acknowledged that foreign remittances in the economy of the State of Kerala in India in the form of money sent by its workers in the Gulf countries play a crucial role. The study finds that by the early nineties remittances to the Kerala economy assumed a significant share of state income. This ranged from 17 percent during 1991-92 and 24 percent during 1997-98 with an average of 22 percent for the second half of the nineties. The liberalisation of the Indian economic policies, particularly the foreign exchange rate, benefited Kerala directly. Adding the remittance income to the Net State Domestic Product, a Modified State Income series has been constructed. As a result Kerala's per capita income not only caught up with the average per capita income for India but started exceeding it reaching 49 percent above the national average by the end of the nineties. This tallies with per capita consumer expenditure in Kerala, which was in excess of 41 percent above the national average by the end of the nineties. Remittances have also made significant impact on savings. By the nineties savings rates in the Kerala economy seem to have reached such high levels comparable to the East and South East Asian countries. The significance of remittances can also be gauged by its relative magnitudes. By the end of the nineties remittances reached such levels that they were well above the total government expenditure, value added in manufacturing and even the value added in industrial sector as a whole.emigration, Gulf countries, Kerala economy, remittances, consumption

International Migration, Remittances and its Macroeconomic Impact on Indian Economy

This paper tried to study the impact of remittances on various macroeconomic and developmental aspects for the Indian economy. For this, the data regarding remittances and some of the macroeconomic variables like GDP, PFCE, GDFC, savings, FDI, FII, export, import and balance of trade deficit etc have been analyzed for the period 1971-2008. The study shows that remittances have been consistently increasing at very fast rate for the last 15 years which have significant implications on the above mentioned macroeconomic variables. Through this study, the importance of remittances as a source of external development finance has been discussed. At last, some of the regulatory frameworks governing the flow of remittances have also been discussed.

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Not AvailableThe objective of the study is to characterize, evaluate and classify 2149 sunflower germplasm accessions during 2011–2012 and 2012–2013 for identification of trait-specific accessions. The analysis of variance revealed significant differences among the genotypes for almost all characters which favour the selection. High heritability associated with high genetic advance as per cent of mean (GAM) was recorded for days to maturity, indicating lesser environmental influence and role of additive gene action. Moderate heritability coupled with moderate-to-low GAM was observed for seed yield per plant, head diameter and oil content, suggesting the low existence of non-additive genes. Associations among characters exist especially for head diameter, 100-seed weight and plant height in the improvement in seed yield, whereas seed yield per plant had a negative correlation with oil content. Based on cluster analysis, 416 accessions grouped under cluster IV may be considered as the genotypes with high yielding ability along with high oil content and medium maturity. The first principal component accounted for 29.20% of the total variation in the population with more contribution from oil content, while second PC contributed 57.6% to days to maturity and 50% flowering contributed maximum. DUS characters such as pigmentation of seedlings, leaf petiole, disc and stem can be considered as morphological markers to differentiate the germplasm. Ray floret colouration, plant branching, type of branching and pollen colour characters can help the breeder to identify the specific germplasm. The identified trait-specific accessions will help in effective utilization of promising accessions in the breedingNot Availabl