9 research outputs found
Video4_Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy.MP4
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.</p
Graphene–Bi<sub>2</sub>Te<sub>3</sub> Heterostructure as Saturable Absorber for Short Pulse Generation
Rapid
progresses have been achieved in the photonic applications
of two-dimensional materials such as graphene, transition metal dichalcogenides,
and topological insulators. The strong light–matter interactions
and large optical nonlinearities in these atomically thin layered
materials make them promising saturable absorbers for pulsed laser
applications. Either Q-switching or mode-locking pulses with particular
output characteristics can be achieved by using different saturable
absorbers. However, it remains still very challenging to produce saturable
absorbers with tunable optical properties, in particular, carrier
dynamics, saturation intensity as well as modulation depth, to suit
for self-starting, high energy or ultrafast pulse laser generation.
Here we report a new type of saturable absorber which is a van der
Waals heterostructure consisting of graphene and Bi<sub>2</sub>Te<sub>3</sub>. The synergetic integration of these two materials by epitaxial
growth affords tunable optical properties, that is, both the photocarrier
dynamics and the nonlinear optical modulation are variable by tuning
the coverage of Bi<sub>2</sub>Te<sub>3</sub> on graphene. We further
fabricated graphene–Bi<sub>2</sub>Te<sub>3</sub> saturable
absorbers and incorporated them into a 1.5 ÎĽm fiber laser to
demonstrate both Q-switching and mode-locking pulse generation. This
work provides a new insight for tailoring two-dimensional heterostructures
so as to develop desired photonic applications
Video1_Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy.MP4
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.</p
Video3_Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy.MP4
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.</p
Video5_Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy.MP4
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.</p
Video2_Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy.MP4
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.</p
Highly Efficient and Air-Stable Infrared Photodetector Based on 2D Layered Graphene–Black Phosphorus Heterostructure
The
presence of a direct band gap and high carrier mobility in few-layer
black phosphorus (BP) offers opportunities for using this material
for infrared (IR) light detection. However, the poor air stability
of BP and its large contact resistance with metals pose significant
challenges to the fabrication of highly efficient IR photodetectors
with long lifetimes. In this work, we demonstrate a graphene–BP
heterostructure photodetector with ultrahigh responsivity and long-term
stability at IR wavelengths. In our device architecture, the top layer
of graphene functions not only as an encapsulation layer but also
as a highly efficient transport layer. Under illumination, photoexcited
electron–hole pairs generated in BP are separated and injected
into graphene, significantly reducing the Schottky barrier between
BP and the metal electrodes and leading to efficient photocurrent
extraction. The graphene–BP heterostructure phototransistor
exhibits a long-term photoresponse at near-infrared wavelength (1550
nm) with an ultrahigh photoresponsivity (up to 3.3 × 10<sup>3</sup> A W<sup>–1</sup>), a photoconductive gain (up to 1.13 ×
10<sup>9</sup>), and a rise time of about 4 ms. Considering the thickness-dependent
band gap in BP, this material represents a powerful photodetection
platform that is able to sustain high performance in the IR wavelength
regime with potential applications in remote sensing, biological imaging,
and environmental monitoring
Ultrathin 2D Transition Metal Carbides for Ultrafast Pulsed Fiber Lasers
Two-dimensional
(2D) materials, such as graphene, transition metal
dichalcogenides, and black phosphorus, have attracted intense interest
for applications in ultrafast pulsed laser generation, owing to their
strong light–matter interactions and large optical nonlinearities.
However, due to the mismatch of the bandgap, many of these 2D materials
are not suitable for applications at near-infrared (NIR) waveband.
Here, we report nonlinear optical properties of 2D α-Mo<sub>2</sub>C crystals and the usage of 2D α-Mo<sub>2</sub>C as
a new broadband saturable absorber for pulsed laser generation. It
was found that 2D α-Mo<sub>2</sub>C crystals have excellent
saturable absorption properties in terms of largely tunable modulation
depth and very low saturation intensity. In addition, ultrafast carrier
dynamic results of 2D α-Mo<sub>2</sub>C reveal an ultrashort
intraband carrier recovery time of 0.48 ps at 1.55 ÎĽm. By incorporating
2D α-Mo<sub>2</sub>C saturable absorber into either an Er-doped
or Yb-doped fiber laser, we are able to generate ultrashort pulses
with very stable operation at central wavelengths of 1602.6 and 1061.8
nm, respectively. Our experimental results demonstrate that 2D α-Mo<sub>2</sub>C can be a promising broadband nonlinear optical media for
ultrafast optical applications