Significantly altered pathway categories in PE decidual transcriptome (p < 0.001).

<p>^a Presented as range where appropriate to reflect the spread of individual p-values of each Gene Ontology (GO) set from each transcriptome profiling batch.</p><p>Significantly altered pathway categories in PE decidual transcriptome (p < 0.001).</p

Downstream genes of identified regulators and targets of maternal PE susceptibility genes.

<p>A gene network of downstream targets of identified regulators/targets of maternal PE susceptibility genes was generated with Pathway Studio 9.0. Each link is supported by at least one published reference. Connecting genes are coloured in yellow, regulator/target genes of maternal PE susceptibility genes in red and major downstream targets of these genes in purple.</p

Summary of patient characteristics.

<p>NA, not applicable.</p><p>^a Shown is the mean ± SEM unless stated otherwise.</p><p>^b Student’s <i>t</i> test with Welch’s Correction for parametric data and 2 × 2 contingency table with Fisher’s Exact Test for categorical data were used.</p><p>^c One PE patient had a twin pregnancy.</p><p>^d Data shown as median.</p><p>Summary of patient characteristics.</p

List of differentially expressed genes in PE decidua (p < 0.001).

<p>^a Weighted to account for effect of the different sample sizes between each transcriptome profiling batch, values above below 0 indicate underexpression in PE relative to control, while values above 0 indicate overexpression in PE relative to control.</p><p>^b Presented as individual p-values from each transcriptome profiling batch.</p><p>List of differentially expressed genes in PE decidua (p < 0.001).</p