Laparoscopic resection of primary tumor with synchronous conventional resection of liver metastases in patients with stage 4 colorectal cancer: A retrospective analysis

Aim: Aim of this study is to analyze the short and long term results of laparoscopic colorectal cancer resection with synchronous conventional resection of liver metastasis. Method: All cases operated on synchronous colorectal cancer and liver metastasis between 2009 and 2017 were retrospectively retrieved from a prospective database. Three and more liver segment resection was considered as major resection. Demographics, patient characteristics, operative and postoperative findings and survival were analyzed. Results: A total of 35 patients [23 (65.7%) male, median age: 56 (34-79)] was included to the study. The most common primary tumor localization was rectum (n=20, 57.1%). Neoadjuvant chemoradiotherapy and chemotherapy was applied in 15 (75%) and 14 (40%) cases, respectively. Major, minor resection or only ablative therapy performance was 12 (34.3%), 19 (54.3%) and 4 (11.4%), respectively, but 13 (37.1%) cases received both resection and ablative therapy. Mean operation time was 307.8±103.6 minutes and estimated blood loss was 300 (10-2200) cc. Blood transfusion was needed in 15 (42.9%) cases. Length of stay was 7 (4-17) days. Eleven complications developed in 10 (28.6%) cases, but none required re-operation. A patient (2.9%) underwent laparoscopic low anterior resection with major hepatectomy and radiofrequency ablation was deceased in postoperative 11th day due to liver failure and subsequent multiorgan failure. Three, 5, 7 and 9-year survival rates was 63%, 35%, 35%, and 35%. Conclusion: Laparoscopic colorectal resection with synchronous conventional liver resection in patients with metastatic colorectal cancer is safe and feasible. Long term survival rates are acceptable.Amaç: Bu çalışmanın amacı karaciğer metastazlı kolorektal kanserli kolorektal tümörün laparoskopik, karaciğer metastaz cerrahisinin ise açık yöntemle tamamlandığı hastalarda kısa ve uzun dönem sonuçları irdelemektir. Yöntem: Prospektif olarak bilgi girişi yapılan bir veri bankasından 2009-2017 yılları arasında senkron metastaz cerrahisi uygulanan ve laparoskopik kolorektal rezeksiyon yapılan hastalar derlendi. ≥3 segment rezeksiyonu majör rezeksiyon olarak nitelendirildi. Demografi ve hastalara ait verilerle, ameliyat ve ameliyat sonrası bilgiler ve sağkalım incelendi. Bulgular: Otuz beş hasta [23 (%65,7) erkek, ortanca 56,0 (34-79) yaş] bulundu. En sık yerleşim yeri rektumdu (n=20, %57,1). Neoadjuvant kemoradyoterapi ve/veya kemoterapi alan olgu sayısı 15 (%75) ve 14 (%40) idi. Majör, minör rezeksiyon veya sadece ablasyon uygulaması sırasıyla 12 (%34,3), 19 (%54,3) ve 4 (%11,4) hastada yapıldı. Ayrıca 13 (%37,1) hastaya hem rezeksiyon ve hem de ablasyon uygulandı. Ortalama operasyon süresi 307,8±103,6 dakikaydı ve kan kaybı miktarı 300 (10-2200) cc idi. On beş (%42,9) hastada kan transfüzyonu gerekti. Hastalar 7 (4-17) günde taburcu edildiler. Toplam 10 (%28,6) hastada en az bir, toplamda ise 11 komplikasyon gelişti. Hiçbir hastaya bu komplikasyonlara bağlı re-operasyon gerekmedi. Laparoskopik aşağı anterior rezeksiyon, majör hepatektomi ve radyofrekans ablasyon uygulanan bir olgu (%2,9) operasyondan 11 gün sonra karaciğer yetmezliğine ikincil gelişen çoklu organ yetmezliğine bağlı olarak kaybedildi. Hastalarda 3, 5, 7 ve 9 yıllık sağkalım oranları %63, %35, %35 ve %35 idi. Sonuç: Karaciğer metastazlı kolorektal kanserlerde, kolorektal kanserin laparoskopik, karaciğer metastaz cerrahisinin ise açık yöntemle uygulanabilir ve güvenilir bir yöntemdir. Uzun dönem sağkalım kabul edilebilir sınırlardadır

Bilateral kasık fıtıklarında transabdominal preperitoneal onarım: Tek merkez deneyimi

Aim: To evaluate outcomes of transabdominal preperitoneal repair in patients with bilateral inguinal hernias. Methods: Sociodemographic data, and data about disease and operation with postoperative data of all patients with bilateral inguinal hernias, who were treated by transabdominal preperitoneal repair were prospectively collected. Patients were followed-up for recurrence and chronic pain in the long-term. Results: A total of 70 (67 [95.7%] males, mean age was 53.4±13.6 years) cases were included. Total 138 hernias (mostly Nyhus type 3 [n=116; 84.1%]) were repaired in 70 cases. Unilateral inguinal hernia was diagnosed in two cases during the operation. Mean operation time was 80.6±26.5 minutes. Inferior epigastric vein was injured in 2 (1.4%) cases. Parenteral analgesics were required in only 10 (14.3%) patients. Patients were discharged 1.21±0.67 days after the operation, and only 9 (12.8%) cases were hospitalized more than one day. Patients returned work or normal activity 10.5±4.7 days after the surgery. The mean follow-up period was 25.9±19.4 months. Symptomatic recurrence was observed in 2 (1.4%) patients. Six (8.7%) cases had chronic pain. Conclusion: Transabdominal preperitoneal repair may be an alternative approach in treatment of bilateral inguinal hernias.Amaç: Bilateral kasık fıtığı olan hastalarda transabdominal preperitoneal tamir sonuçlarını irdelemek. Yöntemler: Transabdominal preperitoneal yöntemle bilateral kasık fıtığı tamiri uygulanan tüm hastalarda prospektif olarak sosyodemografik veriler, hastalık ve operasyona ait veriler ile postoperative veriler değerlendirildi. Uzun dönemde hastalar kronik ağrı ve nüks açısından takip edildi. Bulgular: Toplam 70 hasta (67 [95.7%] erkek, ortalama yaş 53.4±13.6) çalışmaya dahil edildi. İki hastada ameliyat esnasında tek taraflı fıtık saptandığından toplam 138 fıtık (Nyhus tip 3 [n=116; %84.1]) tamiri yapıldı. Ortalama operasyon süresi 80.6±26.5 dakikaydı. İki hastada inferior epigastrik ven yaralanması görüldü. Sadece 10 (%14.3) hastada parenteral analjezik ihtiyacı gelişti. Ortalama hastanede kalış süresi 1.21±0.67 gün olup sadece 9 (%12.8) hastada bir günden fazla yatış gerekti. İş veya normal aktivitelere dönüş süresi 10.5±4.7 gündü. Hastalar ortalama 25.9±19.4 ay takip edildi. Semptomatik nüks 2 (%1.4) hastada gelişti. Kronik ağrı ise 6 (%8.7) hastada saptandı. Sonuç: Bilateral kasık fıtıklarında transabdominal preperitoneal tamir bir alternatif olarak düşünülebili

Outcomes of conversion from laparoscopy to open surgery in geriatric patients with colorectal cancer: A case-control study

Purpose: To evaluate the incidence, risk factors and outcomes of conversion from laparoscopic to open surgery in geriatric patients with colorectal cancer (CRC). Methods: All patients subjected to laparoscopic procedures for CRC between 2006 and 2018 were included. Patients older than 70 were divided into these necessitating or not necessitating conversion to open surgery (Con>70 and Lap>70 groups, respectively), and those younger than 70 requiring conversion were evaluated in Con70 group and the two other groups. Results: Conversion was significantly more common in Con>70 group than Con70 group than those in Lap>70 group. When conversion groups were compared, the rates of surgical site infection and evisceration were higher in geriatric patients. Pathological results revealed that Con>70 group had more advanced tumors than Lap>70 group regarding pT stage, number of malignant lymph nodes and perineural invasion rate. However, the numbers of harvested lymph nodes were similar in two groups. Conclusion: Conversion rate is higher in geriatric patients, particularly in female patients and those who necessitate multivisceral resections. Conversion worsens the perioperative outcomes in geriatric patients. Finally, since the number of harvested lymph nodes does not decrease with conversion, it probably does not threaten the quality of oncological surgery

Akut ve perfore apandisitlerde laparoskopik apendektomi: Karşılaştırmalı analiz

Objective: The purpose of this study was to compare the short-term outcomes of laparoscopically operated uncomplicated acute appendicitis and perforated appendicitis. Methods: Laparoscopically operated uncomplicated acute and perforated appendicitis were screened, retrospectively. Demographics, operative variables, and postoperative complication rates were compared between the groups. Results: Among 155 patients, acute appendicitis was found in 130 patients (77 [59.2%] male; median age, 32 [16–72]), while 25 patients (15 [60.0%] male; median age, 39 [17–84]) had perforated appendicitis. The duration of the operation and hospitalization period were 45 (20–105) minutes and 1 (1–6) day, respectively, in the acute appendicitis group, and 60 (20–155) minutes and 2 (1–16) days, respectively, in the perforated group. Total complication rates were statistically significantly higher in the perforated group. Conclusion: Laparoscopic approach can be applied in selected cases of perforated appendicitis.Amaç: Bu çalışmanın amacı akut komplike olmamış apandisitler ile perfore apandisitlerde laparoskopinin kısa dönem sonuçlarını karşılaştırmaktır. Gereç ve Yöntem: Akut apandisitler tanısıyla laparoskopik apendektomi uygulanmış tüm hastaların kayıtları geriye dönük olarak derlendi. Akut ve perfore apandisit gruplarında demografik veriler, operasyon değişkenleri ve ameliyat sonrası komplikasyon oranları karşılaştırıldı. Bulgular: Toplam 155 hastanın 130’unda (77 [%59.2] erkek, ortanca yaş: 32 [16–72]) akut apandisit saptanmış olup 25 hastada (15 [%60.0] erkek, ortanca yaş: 39 [17–84]) perfore apandisit saptandı. Operasyon süreleri ve hastanede kalış süreleri akut apandisit için 45 (20–105) dakika ve bir (1–6) gün olup perfore apandisit grubunda 60 (20–155) dakika ve iki (1–16) gün idi. Toplam komplikasyon oranları perfore apandisit grubunda anlamlı olarak daha fazlaydı. Sonuç: Seçilmiş perfore apandisit olgularında laparoskopik apendektomi uygulanabilir

The feasibility of hepatic resections using a bipolar radiofrequency device (Habib®)

WOS: 000367103500006PubMed ID: 26702234The bipolar radiofrequency device (HabibA (R)) has been recently introduced in order to reduce intraoperative bleeding for a safe hepatic resection as an alternative to the conventional tools. However, indications, perioperative findings, and outcome of the device for hepatic resections remain and deserve to be analyzed. The current study aims to analyze the feasibility of the bipolar radiofrequency device (HabibA (R)) for hepatic resections. Information of the patients that underwent hepatic resection using with the HabibA (R) device between 2007 and 2011 was abstracted. Patient, disease, and operation-related findings and perioperative data were investigated. A total of 71 cases (38 [53.5 %] males, mean age was 56.8 A +/- 11.9) were analyzed. Metastatic disease (n = 55; 77.5 %) was the leading indication followed by primary liver and biliary malignancies (n = 7; 9.9 %), hemangioma (n = 5; 7 %), hydatid disease (n = 3; 2.8 %), and hepatic gunshot trauma (n = 1; 1.4 %). Metastasectomy was the most commonly performed procedure (n = 31; 56.3 %), but in 24 (77.4 %) cases, it was performed in addition to extended resections. Other procedures in the study patients include segmentectomy in 17, bisegmentectomy in 19, trisegmentectomy in 17, right or left hepatectomy in 8, and extended right/left hepatectomy in 3. The mean (+/- SD) operation time was 241.7 +/- 78.2 min. The median amount of bleeding was 300 cc (range 25-2500), and 23 (32.4 %) cases required perioperative transfusion. The median hospitalization period was 5 days (range 1-47). Lengthened drainage (n = 9, 12.7 %) and intraabdominal abscess (n = 8, 11.23 %) were the most common problems. Hepatic resections using the HabibA (R) device seem to be feasible in cases with primary and metastatic hepatic lesions and benign liver masses and even those with hepatic trauma. It may lessen the amount of intraoperative hemorrhage, although lengthened drainage and intraabdominal abscess were the major postoperative problems in these cases

Laparoscopic Resection of Primary Tumor with Synchronous Conventional Resection of Liver Metastases in Patients with Stage 4 Colorectal Cancer: A Retrospective Analysis

Aim: Aim of this study is to analyze the short and long term results of laparoscopic colorectal cancer resection with synchronous conventional resection of liver metastasis. Method: All cases operated on synchronous colorectal cancer and liver metastasis between 2009 and 2017 were retrospectively retrieved from a prospective database. Three and more liver segment resection was considered as major resection. Demographics, patient characteristics, operative and postoperative findings and survival were analyzed. Results: A total of 35 patients [23 (65.7%) male, median age: 56 (34-79)] was included to the study. The most common primary tumor localization was rectum (n=20, 57.1%). Neoadjuvant chemoradiotherapy and chemotherapy was applied in 15 (75%) and 14 (40%) cases, respectively. Major, minor resection or only ablative therapy performance was 12 (34.3%), 19 (54.3%) and 4 (11.4%), respectively, but 13 (37.1%) cases received both resection and ablative therapy. Mean operation time was 307.8±103.6 minutes and estimated blood loss was 300 (10-2200) cc. Blood transfusion was needed in 15 (42.9%) cases. Length of stay was 7 (4-17) days. Eleven complications developed in 10 (28.6%) cases, but none required re-operation. A patient (2.9%) underwent laparoscopic low anterior resection with major hepatectomy and radiofrequency ablation was deceased in postoperative 11th day due to liver failure and subsequent multiorgan failure. Three, 5, 7 and 9-year survival rates was 63%, 35%, 35%, and 35%. Conclusion: Laparoscopic colorectal resection with synchronous conventional liver resection in patients with metastatic colorectal cancer is safe and feasible. Long term survival rates are acceptable

Comparison of clinical findings in adult and paediatric burn victims

WOS: 000468923000008PubMed ID: 31089018Aim: We aimed to compare the epidemiological data, general characteristics, laboratory findings, and outcomes of burn patients with %18 and 18 years of age. By this way, we also aimed to determine the effective preventive measures appropriate for different age groups. Subjects and Methods: The data of 630 consecutive patients admitted to our hospital with 2(nd) or 3(rd) degree burn injuries were retrospectively investigated. The patients were grouped into two regarding their ages as %18 (group 1) and 18 (group 2) years. Data of age, gender, cause of injury, location of injury, total burn area, length of hospital stay, laboratory data, and outcome of treatment were recorded. Results: We determined that although burn injury is more common in males compared with the females, male predominance is more commonly determined in older age group than children. Extremities are most commonly affected areas in both groups. In children, the most common etiological agent was hot beverages while in older age group electrical burns, and work accidents were more common (P <0.001). Among children, patients younger than 3 years of age were compromising 62.4% of all cases. In adult group, total burned body surface area %, operation or intensive care unit requirement, hospitalization period, blood transfusion, or fresh frozen plasma requirement and the number of patients expired were all significantly higher compared with the children. Regarding the admission laboratory data, renal and liver function tests were significantly worse in older age group. However, neutrophile percentage was significantly higher in older group which may be a sign of augmented inflammatory response. Conclusion: Especially clinicians and public health providers should be aware of the clinical findings and outcomes of burn victims in order to drive more effective preventive measures

A descriptive survey study to evaluate the relationship between socio-demographic factors and quality of life in patients with a permanent colostomy

WOS: 000344515000006PubMed ID: 25299814The impact of having a stoma on quality of life is increasingly recognized and studied. A descriptive survey study was conducted between January 2006 and December 2011 among 44 patients (18 women, 26 men) with a permanent stoma receiving care at the Kartal Training and Research Hospital, Istanbul, Turkey, to evaluate socio-demographic factors that may affect the quality of life in Turkish Muslim patients with an enteral stoma. A socio-demographic questionnaire, a 10-item Religious Orientation Scale (Modified Allport-Ross ROS), and the Medical Outcomes Study Short Form 36 Quality of Life survey were administered by a stoma therapy nurse at least 6 months after completion of all surgical and oncological treatments. The mean follow-up period was 15.3 +/- 9.7 (range 6-44) months since completion of all treatments. Data were collected using paper/pencil instruments and entered for data analysis using Student's t-tests or one-way ANOVA univariate and multivariate analyses. No significant differences were observed for income, education level, surgical history, or religion score. Gender, geographic region, and household status were found independently related to quality of life in stoma patients. Female patients had significantly lower scores than males in general health perception (P=0.049), role emotion (P=0.02), mental health perception (P=0.026), and mental component (P=0.007). Patients living in a village (four) had significantly lower scores than patients living in a big city (33) in all scales (P<0.05 for all comparisons). Village-dwelling patents also had significantly lower scores than patients living in a town (seven) in physical function (P =0.001), vitality (P=0.012), social function (P=0.003), and mental component scores (P=0.021). Patients living alone (seven) had significantly lower scores than patients living with a partner (11) in three of eight scales (physical functioning [P<0.001], role-physical [P=0.047], and bodily pain [P=0.015]) and physical component scores (P<0.001); they also had significantly lower scores than patients living with their families (26) in four of eight scales (physical functioning [P <0.001], role-physical [P=0.032], bodily pain [P=0.02], and general health perception [P=0.036]) and physical component scores (P<0.001). Although these findings provide evidence for the relationship between some socio-demographic factors on quality of life of patients with a stoma, the results of the study should be interpreted with caution; multicenter, prospective, controlled studies are needed to substantiate and clarify the relationships among these variables

Gallbladder perforation during elective laparoscopic cholecystectomy: Incidence, risk factors, and outcomes

WOS: 000433094100010PubMed ID: 29607432OBJECTIVE: This study aimed to reveal the risk factors and outcomes of gallbladder perforation (GP) during laparoscopic cholecystectomy. METHODS: Videotapes of all patients who underwent an elective cholecystectomy at our department were retrospectively analyzed, and the patients were divided into two groups based on the presence of GP. The possible risk factors and early outcomes were analyzed. RESULTS: In total, 664 patients [524 (78.9%) females, 49.7 +/- 13.4 years of age] were observed, and GP occurred in 240 (36.1%) patients, mostly while dissecting the gallbladder from its bed (n=197, 82.1%). GP was not recorded in the operation notes in 177 (73.8%) cases. Among the studied parameters, there was no significant risk factor for GP, except preoperatively elevated alanine transaminase level (p=0.005), but the sensitivity and specificity of this measure in predicting GP were 14.2% and 7.4%, respectively. The two groups had similar outcomes, but the operation time (35.4 +/- 17.5 vs 41.4 +/- 18.7 min, p=0.000) and incidence of drain use (25% vs 45.8%, p=0.000) increased in the GP group. CONCLUSION: The present study reveals that GP occurs in 36.1% of patients who undergo laparoscopic elective cholecystectomy, but it may not be recorded in most cases. We did not find any reliable risk factor that increases the possibility of GP. GP causes an increase in the operation time and incidence of drain use; however, the other outcomes were found to be similar in patients with GP and those without

Fortune of temporary ileostomies in patients treated with laparoscopic low anterior resection for rectal cancer

2016 IEEE International Ultrasonics Symposium, IUS 2016 -- 18 September 2016 through 21 September 2016 -- 124585Purpose: The current study aims to analyze the risk factors for the failure of ileostomy reversal after laparoscopic low anterior resection for rectal cancer. Methods: All patients who underwent a laparoscopic low anterior resection for rectal cancer with a diverting ileostomy between 2007 and 2014 were abstracted. The patients who underwent and did not undergo a diverting ileostomy procedure were compared regarding patient, tumor, treatment related parameters, and survival. Results: Among 160 (103 males [64.4%], mean [± standard deviation] age was 58.1 ± 11.9 years) patients, stoma reversal was achieved in 136 cases (85%). Anastomotic stricture (n = 13, 52.4%) was the most common reason for stoma reversal. These were the risk factors for the failure of stoma reversal: Male sex (P = 0.035), having complications (P = 0.01), particularly an anastomotic leak (P < 0.001), or surgical site infection (P = 0.019) especially evisceration (P = 0.011), requirement for reoperation (P = 0.003) and longer hospital stay (P = 0.004). Multivariate analysis revealed that male sex (odds ratio [OR], 7.82; P = 0.022) and additional organ resection (OR, 6.71; P = 0.027) were the risk factors. Five-year survival rates were similar (P = 0.143). Conclusion: Fifteen percent of patients cannot receive a stoma reversal after laparoscopic low anterior resection for rec tal cancer. Anastomotic stricture is the most common reason for the failure of stoma takedown. Having complications, particularly an anastomotic leak and the necessity of reoperation, limits the stoma closure rate. Male sex and additional organ resection are the risk factors for the failure in multivariate analyses. These patients require a longer hospitalization period, but have similar survival rates as those who receive stoma closure procedure