EKSTRAK ETANOL PROPOLIS ISOLAT GUNUNG LAWU MENURUNKAN KADAR IgE SERUM TIKUS PUTIH (Rottas norvegicus I,) MODELASMAAKUT . (Ethanolic Extracts of Propalis Lawu mountain isolates reduce serum IgE levels in Rattus norvegicus L model of ucute asthma)

IgE plays a pivotal role in allergic asthma especially in the acute response to antigen and in the propagation of airw,ay inflammation. Propolis which has been used widely in folk medicine, has been shown to exhibit various biological activilies. Investigation of these activities ofpropolis using an ovalbumin-induced asthma animcl model has been conducted- Mousewere immunized and sensitized by exposure to ovalbumin (OVA) antigen and administered propolis ethanolic extrocts with dose I (6 mg/kg body weightlday) and dose II (7.5 mg/kg body weight/day) by tube feeding. The investigation demonstrated that propolis ethanalic extracts could suppressed the serum levels of IgE in OVA-sensitized mouse. This study showed serum ISE levels of control nxouse wos 12.72+2.74ng/mL, asthma group 42.04t12.23 ng/ml, asthmo*Propolis dose I l6-6014-45 ng/mL, Asthma* Propolis dose II 11.68L3.85 ng/mL and asthma*antihistamine 15.92*5.49 ng/mL- These results suggested that propolis extracts mqy be apotential novel therapeutic agentfor allergic osthma. Keywords: asthma, propolis, Ig