Speckle Interferometry of Metal-Poor Stars in the Solar Neighborhood. I

We report the results of speckle-interferometric observations of 109 high proper-motion metal-poor stars made with the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences. We resolve eight objects -- G102-20, G191-55, BD+19$^\circ$~1185A, G89-14, G87-45, G87-47, G111-38, and G114-25 -- into individual components and we are the first to astrometrically resolve seven of these stars. New resolved systems included two triple (G111-38, G87-47) and one quadruple (G89-14) star. The ratio of single-to-binary-to-triple-to-quadruple systems among the stars of our sample is equal to 71:28:6:1.Comment: 8 pages, 4 figures, accepted to Astrophysical Bulleti

Variability and Action Mechanism of a Family of Anticomplement Proteins in Ixodes ricinus

Background: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response. This is achieved by expressing batteries of salivary proteins coded by multigene families. Methodology/Principal Findings: We report the in-depth analysis of a tick multigene family and describe five new anticomplement proteins in ixodes ricinus. Compared to previously described Ixodes anticomplement proteins, these segregated into a new phylogenetic group or subfamily. These proteins have a novel action mechanism as they specifically bind to properdin, leading to the inhibition of C3 convertase and the alternative complement pathway. An excess of non-synonymous over synonymous changes indicated that coding sequences had undergone diversifying selection. Diversification was not associated with structural, biochemical o, functional diversity, adaptation to host species or stage specificity but rather to differences in antigenicity. Conclusion/Significance: Anticomplement proteins from I. ricinus are the first inhibitors that specifically target a positive regulator of complement, properdin. They may provide new tools for the investigation of role of properdin in physiological and pathophysiological mechanisms. They may also be useful in disorders affecting the alternative complement pathway, Looking for and detecting the different selection pressures involved will help in understanding the evolution of multigene families and hematophagy in arthropods. © 2008 Couveur et al.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe