13,186 research outputs found
An Enzyomatic Assay Convenient for the Control of Aprotinin Levels During Proteinase Inhibitor Therapy
Advanced spacecraft thermal control techniques
The problems of rejecting large amounts of heat from spacecraft were studied. Shuttle Space Laboratory heat rejection uses 1 kW for pumps and fans for every 5 kW (thermal) heat rejection. This is rather inefficient, and for future programs more efficient methods were examined. Two advanced systems were studied and compared to the present pumped-loop system. The advanced concepts are the air-cooled semipassive system, which features rejection of a large percentage of the load through the outer skin, and the heat pipe system, which incorporates heat pipes for every thermal control function
Self-compensating solenoid valve
A solenoid valve is described in which both an inlet and an outlet of the valve are sealed when the valve is closed. This double seal compensates for leakage at either the inlet or the outlet by making the other seal more effective in response to the leakage and allows the reversal of the flow direction by simply switching the inlet and outlet connections. The solenoid valve has a valve chamber within the valve body. Inlet and outlet tubes extend through a plate into the chamber. A movable core in the chamber extends into the solenoid coil. The distal end of the core has a silicone rubber plug. Other than when the solenoid is energized, the compressed spring biases the core downward so that the surface of the plug is in sealing engagement with the ends of the tubes. A leak at either end increases the pressure in the chamber, resulting in increased sealing force of the plug
The control of wing kinematics and flight forces in fruit flies (Drosophila spp.)
By simultaneously measuring flight forces and stroke kinematics in several species of fruit flies in the genus Drosophila, we have investigated the relationship between wing motion and aerodynamic force production. We induced tethered flies to vary their production of total flight force by presenting them with a vertically oscillating visual background within a closed-loop flight arena. In response to the visual motion, flies modulated their flight force by changing the translational velocity of their wings, which they accomplished via changes in both stroke amplitude and stroke frequency. Changes in wing velocity could not, however, account for all the modulation in flight force, indicating that the mean force coefficient of the wings also increases with increasing force production. The mean force coefficients were always greater than those expected under steady-state conditions under a variety of assumptions, verifying that force production in Drosophila spp. must involve non-steady-state mechanisms. The subtle changes in kinematics and force production within individual flight sequences demonstrate that flies possess a flexible control system for flight maneuvers in which they can independently control the stroke amplitude, stroke frequency and force coefficient of their wings. By studying four different-sized species, we examined the effects of absolute body size on the production and control of aerodynamic forces. With decreasing body size, the mean angular wing velocity that is required to support the body weight increases. This change is due almost entirely to an increase in stroke frequency, whereas mean stroke amplitude was similar in all four species. Despite the elevated stroke frequency and angular wing velocity, the translational velocity of the wings in small flies decreases with the reduction in absolute wing length. To compensate for their small size, D. nikananu must use higher mean force coefficients than their larger relatives
The changes in power requirements and muscle efficiency during elevated force production in the fruit fly Drosophila melanogaster
The limits of flight performance have been estimated in tethered Drosophila melanogaster by modulating power requirements in a 'virtual reality' flight arena. At peak capacity, the flight muscles can sustain a mechanical power output of nearly 80 W kg^(-1) muscle mass at 24 °C, which is sufficient to generate forces of approximately 150% of the animal's weight. The increase in flight force above that required to support body weight is accompanied by a rise in wing velocity, brought about by an increase in stroke amplitude and a decrease in stroke frequency. Inertial costs, although greater than either profile or induced power, would be minimal with even modest amounts of elastic storage, and total mechanical power energy should be equivalent to aerodynamic power alone. Because of the large profile drag expected at low Reynolds numbers, the profile power was approximately twice the induced power at all levels of force generation. Thus, it is the cost of overcoming drag, and not the production of lift, that is the primary requirement for flight in Drosophila melanogaster. By comparing the estimated mechanical power output with respirometrically measured total power input, we determined that muscle efficiency rises with increasing force production to a maximum of 10%. This change in efficiency may reflect either increased crossbridge activation or a favorable strain regime during the production of peak forces
The production of elevated flight force compromises manoeuvrability in the fruit fly Drosophila melanogaster
In this study, we have investigated how enhanced total flight force production compromises steering performance in tethered flying fruit flies, Drosophila melanogaster. The animals were flown in a closed-loop virtual-reality flight arena in which they modulated total flight force production in response to vertically oscillating visual patterns. By simultaneously measuring stroke amplitude and stroke frequency, we recorded the ability of each fly to modulate its wing kinematics at different levels of aerodynamic force production. At a flight force that exactly compensates body weight, the temporal deviations with which fruit flies vary their stroke amplitude and frequency are approximately 27° and 4.8 Hz of their mean value, respectively. This variance in wing kinematics decreases with increasing flight force production, and at maximum force production fruit flies are restricted to a unique combination of stroke amplitude, stroke frequency and mean force coefficient. This collapse in the kinematic envelope during peak force production could greatly attenuate the manoeuvrability and stability of animals in free flight
The scaling of carbon dioxide release and respiratory water loss in flying fruit flies (Drosophila spp.)
By simultaneously measuring carbon dioxide release, water loss and flight force in several species of fruit flies in the genus Drosophila, we have investigated respiration and respiratory transpiration during elevated locomotor activity. We presented tethered flying flies with moving visual stimuli in a virtual flight arena, which induced them to vary both flight force and energetic output. In response to the visual motion, the flies altered their energetic output as measured by changes in carbon dioxide release and concomitant changes in respiratory water loss. We examined the effect of absolute body size on respiration and transpiration by studying four different-sized species of fruit flies. In resting flies, body-mass-specific CO(2) release and water loss tend to decrease more rapidly with size than predicted according to simple allometric relationships. During flight, the mass-specific metabolic rate decreases with increasing body size with an allometric exponent of -0.22, which is slightly lower than the scaling exponents found in other flying insects. In contrast, the mass-specific rate of water loss appears to be proportionately greater in small animals than can be explained by a simple allometric model for spiracular transpiration. Because fractional water content does not change significantly with increasing body size, the smallest species face not only larger mass-specific energetic expenditures during flight but also a higher risk of desiccation than their larger relatives. Fruit flies lower their desiccation risk by replenishing up to 75 % of the lost bulk water by metabolic water production, which significantly lowers the risk of desiccation for animals flying under xeric environmental conditions
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