3 research outputs found
THE EXPERIENCE OF HOPANTENIC ACID APPLICATION IN THE SYRUP FOR THE CHILDREN, SUFFERING FROM EPILEPSY WITH COGNITIVE DISORDERS AND ATTENTION DEFICIT AND HYPERACTIVITY DISORDER
The search for nootropic medications, which don't aggravate the implications of the hyperactivity disorder and sleep disturbances, is an urgent issue in the children's neurology. For the purpose of pantohamium sirupus appraisal, the researchers examined 20 patient aged between 3 years old and 4 years 11 months old, suffering from epilepsy with cognitive disorders and attention deficit and hyperactivity disorder. All the patients underwent interviewing with the composite questionnaire, oddball tasks, mechanical memory tests (memorizing 3β4 words), dynamic memory tests (repeating 2 groups of words), colour test (for the children of 4 years old), as well as electroencephalography and by indications clinical and biochemical examination. After the course of panto hamium sirupus treatment the researchers discovered the general improvement of attention, mechanical and dynamic memory, anxiety reduction and compensation boost based on the colour test conducted among the children, suffering from epilepsy with attention deficit and hyperactivity disorder. Most patients showed the improvement indices of the EEG background rhythm structure and normalization of background zone differences. The analysis of the obtained results allowed the researchers to conclude that pantohamium sirupus was safe and efficient in the complex therapy among the children, suffering from epilepsy with cognitive disorders and attention deficit and hyperactivity disorder.Key words: hopantenic acid, pantohamium, epilepsy, attention deficit, hyperactivity, cognitive disorders.</strong
Π’ΡΠ°Π½Π·ΠΈΡΠΎΡΠ½ΡΠ΅ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΡΠ΅ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΈ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ², ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ
The problem of a paediatric stroke has become relevant in recent decades. More than 50% of children with ischemic stroke are diagnosed with arteriopathy. The article presents observation of 61 patients with a confirmed diagnosis of arterial AI who underwent inpatient treatment at the Morozov City Child Clinic for the period from 2013 to 2018. 37 of them were boys, the average age of children was 7.8 years. The follow-up period was 16 months to 5 years (an average of 2.6 years). In 35 children from 61, according to neuroimaging, in the acute period, signs of arteriopathy were revealed. Of these, 24/31 revealed signs of unilateral focal stenosis of the cerebral arteries that did not correspond to the clinical and radiological picture of other types of arteriopathies, which were regarded in the framework of the focal cerebral arteriopathy. The analysis of clinical, laboratory and neuroimaging characteristics in groups of children with transient cerebral arteriopathy (TCAs) and without it was carried out. Progression of the neurological deficit and a less favorable outcome in children in the TCA group was noted. The need to isolate patients with arteriopathy is noted, which determines the tactics of dynamic observation and treatment.ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π΄Π΅ΡΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° ΡΡΠ°Π»Π° Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ. Π£ Π±ΠΎΠ»Π΅Π΅ 50% Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈΠ½ΡΡΠ»ΡΡΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΠ΅ΡΡΡ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΡ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° 61 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΌ Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° (ΠΠ), ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² ΠΠΠ£Π Β«ΠΠΎΡΠΎΠ·ΠΎΠ²ΡΠΊΠ°Ρ ΠΠΠΠ ΠΠΠΒ» Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2013 ΠΏΠΎ 2018 Π³Π³. 37 ΠΈΠ· Π½ΠΈΡ
Π±ΡΠ»ΠΈ ΠΌΠ°Π»ΡΡΠΈΠΊΠΈ, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ Π΄Π΅ΡΠ΅ΠΉ - 7,8 Π»Π΅Ρ. ΠΠ΅ΡΠΈΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» ΠΎΡ 16 ΠΌΠ΅ΡΡΡΠ΅Π² Π΄ΠΎ 5 Π»Π΅Ρ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 2,6 Π³ΠΎΠ΄Π°). Π£ 35 Π΄Π΅ΡΠ΅ΠΉ ΠΈΠ· 61, ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π½Π΅ΠΉΡΠΎΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ. ΠΠ· Π½ΠΈΡ
Ρ 24/31 Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΎΠ΄Π½ΠΎΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΡΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΎΠ·Π° ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠΉ, Π½Π΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Π΅ Π΄ΡΡΠ³ΠΈΠΌ Π²ΠΈΠ΄Π°ΠΌ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ Π±ΡΠ»ΠΈ ΡΠ°ΡΡΠ΅Π½Π΅Π½Ρ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΡΠΎΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ (Π€Π¦Π). ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΈ Π½Π΅ΠΉΡΠΎΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π² Π³ΡΡΠΏΠΏΠ°Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΡΠ°Π½Π·ΠΈΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ (Π’Π¦Π) ΠΈ Π±Π΅Π· Π½Π΅Π΅. ΠΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΈ ΠΌΠ΅Π½Π΅Π΅ Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΉ ΠΈΡΡ
ΠΎΠ΄ Ρ Π΄Π΅ΡΠ΅ΠΉ Π² Π³ΡΡΠΏΠΏΠ΅ Ρ Π’Π¦Π. ΠΡΠΌΠ΅ΡΠ΅Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ
Π’ΡΠ°Π½Π·ΠΈΡΠΎΡΠ½ΡΠ΅ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΡΠ΅ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΈ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ², ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ
The problem of a paediatric stroke has become relevant in recent decades. More than 50% of children with ischemic stroke are diagnosed with arteriopathy. The article presents observation of 61 patients with a confirmed diagnosis of arterial AI who underwent inpatient treatment at the Morozov City Child Clinic for the period from 2013 to 2018. 37 of them were boys, the average age of children was 7.8 years. The follow-up period was 16 months to 5 years (an average of 2.6 years). In 35 children from 61, according to neuroimaging, in the acute period, signs of arteriopathy were revealed. Of these, 24/31 revealed signs of unilateral focal stenosis of the cerebral arteries that did not correspond to the clinical and radiological picture of other types of arteriopathies, which were regarded in the framework of the focal cerebral arteriopathy. The analysis of clinical, laboratory and neuroimaging characteristics in groups of children with transient cerebral arteriopathy (TCAs) and without it was carried out. Progression of the neurological deficit and a less favorable outcome in children in the TCA group was noted. The need to isolate patients with arteriopathy is noted, which determines the tactics of dynamic observation and treatment.ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π΄Π΅ΡΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° ΡΡΠ°Π»Π° Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ. Π£ Π±ΠΎΠ»Π΅Π΅ 50% Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈΠ½ΡΡΠ»ΡΡΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΠ΅ΡΡΡ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΡ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° 61 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΌ Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° (ΠΠ), ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² ΠΠΠ£Π Β«ΠΠΎΡΠΎΠ·ΠΎΠ²ΡΠΊΠ°Ρ ΠΠΠΠ ΠΠΠΒ» Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2013 ΠΏΠΎ 2018 Π³Π³. 37 ΠΈΠ· Π½ΠΈΡ
Π±ΡΠ»ΠΈ ΠΌΠ°Π»ΡΡΠΈΠΊΠΈ, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ Π΄Π΅ΡΠ΅ΠΉ - 7,8 Π»Π΅Ρ. ΠΠ΅ΡΠΈΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» ΠΎΡ 16 ΠΌΠ΅ΡΡΡΠ΅Π² Π΄ΠΎ 5 Π»Π΅Ρ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 2,6 Π³ΠΎΠ΄Π°). Π£ 35 Π΄Π΅ΡΠ΅ΠΉ ΠΈΠ· 61, ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π½Π΅ΠΉΡΠΎΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ. ΠΠ· Π½ΠΈΡ
Ρ 24/31 Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΎΠ΄Π½ΠΎΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΡΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΎΠ·Π° ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠΉ, Π½Π΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Π΅ Π΄ΡΡΠ³ΠΈΠΌ Π²ΠΈΠ΄Π°ΠΌ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ Π±ΡΠ»ΠΈ ΡΠ°ΡΡΠ΅Π½Π΅Π½Ρ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΡΠΎΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠΈ (Π€Π¦Π). ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΈ Π½Π΅ΠΉΡΠΎΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π² Π³ΡΡΠΏΠΏΠ°Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΡΠ°Π½Π·ΠΈΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ (Π’Π¦Π) ΠΈ Π±Π΅Π· Π½Π΅Π΅. ΠΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΈ ΠΌΠ΅Π½Π΅Π΅ Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΉ ΠΈΡΡ
ΠΎΠ΄ Ρ Π΄Π΅ΡΠ΅ΠΉ Π² Π³ΡΡΠΏΠΏΠ΅ Ρ Π’Π¦Π. ΠΡΠΌΠ΅ΡΠ΅Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π°ΡΡΠ΅ΡΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ