3 research outputs found

    THE EXPERIENCE OF HOPANTENIC ACID APPLICATION IN THE SYRUP FOR THE CHILDREN, SUFFERING FROM EPILEPSY WITH COGNITIVE DISORDERS AND ATTENTION DEFICIT AND HYPERACTIVITY DISORDER

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    The search for nootropic medications, which don't aggravate the implications of the hyperactivity disorder and sleep disturbances, is an urgent issue in the children's neurology. For the purpose of pantohamium sirupus appraisal, the researchers examined 20 patient aged between 3 years old and 4 years 11 months old, suffering from epilepsy with cognitive disorders and attention deficit and hyperactivity disorder. All the patients underwent interviewing with the composite questionnaire, oddball tasks, mechanical memory tests (memorizing 3–4 words), dynamic memory tests (repeating 2 groups of words), colour test (for the children of 4 years old), as well as electroencephalography and by indications clinical and biochemical examination. After the course of panto hamium sirupus treatment the researchers discovered the general improvement of attention, mechanical and dynamic memory, anxiety reduction and compensation boost based on the colour test conducted among the children, suffering from epilepsy with attention deficit and hyperactivity disorder. Most patients showed the improvement indices of the EEG background rhythm structure and normalization of background zone differences. The analysis of the obtained results allowed the researchers to conclude that pantohamium sirupus was safe and efficient in the complex therapy among the children, suffering from epilepsy with cognitive disorders and attention deficit and hyperactivity disorder.Key words: hopantenic acid, pantohamium, epilepsy, attention deficit, hyperactivity, cognitive disorders.</strong

    Π’Ρ€Π°Π½Π·ΠΈΡ‚ΠΎΡ€Π½Ρ‹Π΅ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ ΠΈ подростков, особСнности клиничСских проявлСний ΠΈ тСчСния

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    The problem of a paediatric stroke has become relevant in recent decades. More than 50% of children with ischemic stroke are diagnosed with arteriopathy. The article presents observation of 61 patients with a confirmed diagnosis of arterial AI who underwent inpatient treatment at the Morozov City Child Clinic for the period from 2013 to 2018. 37 of them were boys, the average age of children was 7.8 years. The follow-up period was 16 months to 5 years (an average of 2.6 years). In 35 children from 61, according to neuroimaging, in the acute period, signs of arteriopathy were revealed. Of these, 24/31 revealed signs of unilateral focal stenosis of the cerebral arteries that did not correspond to the clinical and radiological picture of other types of arteriopathies, which were regarded in the framework of the focal cerebral arteriopathy. The analysis of clinical, laboratory and neuroimaging characteristics in groups of children with transient cerebral arteriopathy (TCAs) and without it was carried out. Progression of the neurological deficit and a less favorable outcome in children in the TCA group was noted. The need to isolate patients with arteriopathy is noted, which determines the tactics of dynamic observation and treatment.ΠŸΡ€ΠΎΠ±Π»Π΅ΠΌΠ° дСтского ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚Π° стала Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π² послСдниС дСсятилСтия. Π£ Π±ΠΎΠ»Π΅Π΅ 50% Π΄Π΅Ρ‚Π΅ΠΉ с ΠΈΡˆΠ΅ΠΌΠΈΡ‡Π΅ΡΠΊΠΈΠΌ ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚ΠΎΠΌ диагностируСтся артСриопатия. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСно наблюдСниС Π·Π° 61 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠΌ с ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π½Ρ‹ΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈΡˆΠ΅ΠΌΠΈΡ‡Π΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚Π° (ИИ), ΠΏΡ€ΠΎΡ…ΠΎΠ΄ΠΈΠ²ΡˆΠΈΡ… стационарноС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π² Π“Π‘Π£Π— Β«ΠœΠΎΡ€ΠΎΠ·ΠΎΠ²ΡΠΊΠ°Ρ Π”Π“ΠšΠ‘ Π”Π—ΠœΒ» Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2013 ΠΏΠΎ 2018 Π³Π³. 37 ΠΈΠ· Π½ΠΈΡ… Π±Ρ‹Π»ΠΈ ΠΌΠ°Π»ΡŒΡ‡ΠΈΠΊΠΈ, срСдний возраст Π΄Π΅Ρ‚Π΅ΠΉ - 7,8 Π»Π΅Ρ‚. ΠŸΠ΅Ρ€ΠΈΠΎΠ΄ наблюдСния составил ΠΎΡ‚ 16 мСсяцСв Π΄ΠΎ 5 Π»Π΅Ρ‚ (Π² срСднСм 2,6 Π³ΠΎΠ΄Π°). Π£ 35 Π΄Π΅Ρ‚Π΅ΠΉ ΠΈΠ· 61, ΠΏΠΎ Π΄Π°Π½Π½Ρ‹ΠΌ Π½Π΅ΠΉΡ€ΠΎΠ²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π² остром ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ выявлСны ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ. Из Π½ΠΈΡ… Ρƒ 24/31 зафиксированы ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ одностороннСго Ρ„ΠΎΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ стСноза Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΉ, Π½Π΅ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-рСнтгСнологичСской ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Π΅ Π΄Ρ€ΡƒΠ³ΠΈΠΌ Π²ΠΈΠ΄Π°ΠΌ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΉ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π±Ρ‹Π»ΠΈ расцСнСны Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Ρ„ΠΎΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ (ЀЦА). ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· клиничСских, Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΈ Π½Π΅ΠΉΡ€ΠΎΠ²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… особСнностСй Π² Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… Π΄Π΅Ρ‚Π΅ΠΉ с Ρ‚Ρ€Π°Π½Π·ΠΈΡ‚ΠΎΡ€Π½ΠΎΠΉ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠ΅ΠΉ (ВЦА) ΠΈ Π±Π΅Π· Π½Π΅Π΅. Π‘Ρ‹Π»ΠΎ выявлСно прогрСссированиС нСврологичСского Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚Π° ΠΈ ΠΌΠ΅Π½Π΅Π΅ благоприятный исход Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ с ВЦА. ΠžΡ‚ΠΌΠ΅Ρ‡Π΅Π½Π° Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ выдСлСния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠ΅ΠΉ для опрСдСлСния Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΈ динамичСского наблюдСния ΠΈ лСчСния

    Π’Ρ€Π°Π½Π·ΠΈΡ‚ΠΎΡ€Π½Ρ‹Π΅ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ ΠΈ подростков, особСнности клиничСских проявлСний ΠΈ тСчСния

    No full text
    The problem of a paediatric stroke has become relevant in recent decades. More than 50% of children with ischemic stroke are diagnosed with arteriopathy. The article presents observation of 61 patients with a confirmed diagnosis of arterial AI who underwent inpatient treatment at the Morozov City Child Clinic for the period from 2013 to 2018. 37 of them were boys, the average age of children was 7.8 years. The follow-up period was 16 months to 5 years (an average of 2.6 years). In 35 children from 61, according to neuroimaging, in the acute period, signs of arteriopathy were revealed. Of these, 24/31 revealed signs of unilateral focal stenosis of the cerebral arteries that did not correspond to the clinical and radiological picture of other types of arteriopathies, which were regarded in the framework of the focal cerebral arteriopathy. The analysis of clinical, laboratory and neuroimaging characteristics in groups of children with transient cerebral arteriopathy (TCAs) and without it was carried out. Progression of the neurological deficit and a less favorable outcome in children in the TCA group was noted. The need to isolate patients with arteriopathy is noted, which determines the tactics of dynamic observation and treatment.ΠŸΡ€ΠΎΠ±Π»Π΅ΠΌΠ° дСтского ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚Π° стала Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π² послСдниС дСсятилСтия. Π£ Π±ΠΎΠ»Π΅Π΅ 50% Π΄Π΅Ρ‚Π΅ΠΉ с ΠΈΡˆΠ΅ΠΌΠΈΡ‡Π΅ΡΠΊΠΈΠΌ ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚ΠΎΠΌ диагностируСтся артСриопатия. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСно наблюдСниС Π·Π° 61 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠΌ с ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π½Ρ‹ΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈΡˆΠ΅ΠΌΠΈΡ‡Π΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡƒΠ»ΡŒΡ‚Π° (ИИ), ΠΏΡ€ΠΎΡ…ΠΎΠ΄ΠΈΠ²ΡˆΠΈΡ… стационарноС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π² Π“Π‘Π£Π— Β«ΠœΠΎΡ€ΠΎΠ·ΠΎΠ²ΡΠΊΠ°Ρ Π”Π“ΠšΠ‘ Π”Π—ΠœΒ» Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2013 ΠΏΠΎ 2018 Π³Π³. 37 ΠΈΠ· Π½ΠΈΡ… Π±Ρ‹Π»ΠΈ ΠΌΠ°Π»ΡŒΡ‡ΠΈΠΊΠΈ, срСдний возраст Π΄Π΅Ρ‚Π΅ΠΉ - 7,8 Π»Π΅Ρ‚. ΠŸΠ΅Ρ€ΠΈΠΎΠ΄ наблюдСния составил ΠΎΡ‚ 16 мСсяцСв Π΄ΠΎ 5 Π»Π΅Ρ‚ (Π² срСднСм 2,6 Π³ΠΎΠ΄Π°). Π£ 35 Π΄Π΅Ρ‚Π΅ΠΉ ΠΈΠ· 61, ΠΏΠΎ Π΄Π°Π½Π½Ρ‹ΠΌ Π½Π΅ΠΉΡ€ΠΎΠ²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π² остром ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ выявлСны ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ. Из Π½ΠΈΡ… Ρƒ 24/31 зафиксированы ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ одностороннСго Ρ„ΠΎΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ стСноза Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΉ, Π½Π΅ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-рСнтгСнологичСской ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Π΅ Π΄Ρ€ΡƒΠ³ΠΈΠΌ Π²ΠΈΠ΄Π°ΠΌ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΉ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π±Ρ‹Π»ΠΈ расцСнСны Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Ρ„ΠΎΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠΈ (ЀЦА). ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· клиничСских, Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΈ Π½Π΅ΠΉΡ€ΠΎΠ²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… особСнностСй Π² Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… Π΄Π΅Ρ‚Π΅ΠΉ с Ρ‚Ρ€Π°Π½Π·ΠΈΡ‚ΠΎΡ€Π½ΠΎΠΉ Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠ΅ΠΉ (ВЦА) ΠΈ Π±Π΅Π· Π½Π΅Π΅. Π‘Ρ‹Π»ΠΎ выявлСно прогрСссированиС нСврологичСского Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚Π° ΠΈ ΠΌΠ΅Π½Π΅Π΅ благоприятный исход Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ с ВЦА. ΠžΡ‚ΠΌΠ΅Ρ‡Π΅Π½Π° Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ выдСлСния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠΎΠΏΠ°Ρ‚ΠΈΠ΅ΠΉ для опрСдСлСния Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΈ динамичСского наблюдСния ΠΈ лСчСния
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