The efficacy of preopoerative instruction in reducing anxiety following gyneoncological surgery: a case control study

<p>Abstract</p> <p>Background</p> <p>This is a quasi-experimental case control research focusing on the impact of systematic preoperative instruction on the level of postoperative anxiety in gyneoncologic patients. The population studied consists of the gyneoncologic surgery patients admitted to the Gynecologic Oncology Service at Zekai Tahir Burak Gynecology Training and Research Hospital from May to September 2010.</p> <p>Patients and methods</p> <p>Through a random sampling, 60 patients were recruited in each group. The study group was given a systematic preoperative instruction while the control group was given routine nursing care. Patients were interviewed in the postoperative period and anxiety was measured. The data-collecting tool consisted of the Individual Information Form and the State-Trait Anxiety Inventory. The collected data were analyzed by using the SPSS Program to find the frequency, the percentage, the mean and the standard variables, and the hypothesis was tested with Chi-square, variance, and t-independent test.</p> <p>Results</p> <p>It was found that the incidence rates from the post-operative anxiety score of the study group were lower than those of the control group (p < .05). The results of this research demonstrated that gyneoncologic surgery patients who were given systematic preoperative instruction felt less anxious than the ones who were given merely a routine nursing care.</p> <p>Conclusions</p> <p>Results of this study suggest that preoperative instruction programs aiming at informing gyneoncologic surgery patients at the preoperative stage should be organized in hospitals and have an essential role.</p

Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients

Paired box 1 (PAX1) deficiency has been reported in a small number of patients diagnosed with otofaciocervical syndrome type 2 (OFCS2). We described six new patients who demonstrated variable clinical penetrance. Reduced transcriptional activity of pathogenic variants confirmed partial or complete PAX1 deficiency. Thymic aplasia and hypoplasia were associated with impaired T cell immunity. Corrective treatment was required in 4/6 patients. Hematopoietic stem cell transplantation resulted in poor immune reconstitution with absent naïve T cells, contrasting with the superior recovery of T cell immunity after thymus transplantation. Normal ex vivo differentiation of PAX1-deficient CD34+ cells into mature T cells demonstrated the absence of a hematopoietic cell-intrinsic defect. New overlapping features with DiGeorge syndrome included primary hypoparathyroidism (n = 5) and congenital heart defects (n = 2), in line with PAX1 expression during early embryogenesis. Our results highlight new features of PAX1 deficiency, which are relevant to improving early diagnosis and identifying patients requiring corrective treatment

GEOPARK INVENTORY STUDY OF LEVENT VALLEY, AKCADAG-MALATYA

The purposes of "Levent Valley Geopark Inventory Study" investigate each of many caves "which known to be over hundred" and study and record geological structures which could develop to become geosite both within the valley and the surrounding area. In Levent Valley -which is located at Levent, Akcadag village of Malatya-Lithostratigraphic units are surfaced dating back to Upper Cretaceous-Pliocene. The karstic caves found on the joints which is result of cross cutting of the faults of the main faults cutting through the valley, are mostly shaped by people who lived in the valley

Evaluation of Patients with Behcet's Disease Presenting with Pulmonary Symptoms

Objective: Behcet's disease (BD) is a multisystem disorder and survival depends on pulmonary involvement, especially pulmonary artery aneurysm. Therefore early diagnosis and treatment of pulmonary involvement are very important. This study was conducted to evaluate clinical features, treatment results and outcome of patients with BD presenting with pulmonary symptoms. Material and Methods: Medical records of patients diagnosed as BD over a 17-years period from 1991 to 2008 who presented with pulmonary symptoms in two different chest clinics were reviewed retrospectively. Clinical and radiological findings, treatment and follow-up results were investigated. Results: Twenty-two patients (19 males, three females) diagnosed with BD were included. The mean age was 35.4 years. Sixteen of the patients (72.7%) were diagnosed with BD at chest clinics for first time. Main presenting pulmonary symptom was hemoptysis (72.7%) and six of them (27.3%) had massive hemoptysis. Thirteen patients (59%) had pulmonary artery aneurysms, five of them also had thrombosis within the aneurysm. Nineteen patients (86%) were administered immunosupressive therapy. Eighteen (81.8%) of the patients were followed, median follow-up time was four years. Thirteen patients responded to immunosuppressive therapy. Three patients (16.7%) died, two of them with massive hemoptysis. Conclusion: BD should be kept in mind in differential diagnosis of hemoptysis in young patients, especially in countries with high incidence of BD. Early diagnosis and aggressive treatment for pulmonary involvement can prevent a fatal outcome

Relation of Biochemical Parameters with Flow-mediated Dilatation in Patients with Metabolic Syndrome

Background: Metabolic syndrome (MetS) is one of the high cardiovascular (CV) situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the major CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS. Methods: The study was performed between December 2010 and August 2014. Atotal of 55 patients(15 females and 40 males) with MetS and 81 healthy controls (37 females and 44 males) with a body mass index &lt;25 kg/m2 were enrolled in the study. Endothelial dysfunction was measured by flow-mediated dilatation (FMD), oxidative stress parameters; high-sensitivity C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), endothelial nitric oxide synthase (e-NOS), nitric oxide, and cell adhesion markers; von Willebrand factor, and e-selectin. Platelet aggregation (endothelial adenosine diphosphate), total platelet count, and mean platelet volume were additionally analyzed and demographic parameters were explored. Student&rsquo;s t-test, Mann-Whitney U-test, and Chi-square test were used to analyze the results. Results: The fasting blood glucose (z = 3.52, P = 0.001), hs-CRP (z = 3.23, P = 0.004), ox-LDL(z = 2.62, P = 0.013), and e-NOS (z = 2.22, P = 0.026) levels and cardiac risk score (z = 5.23, P &lt; 0.001) were significantly higher in patients with MetS compared with the control group. Smoking was correlated with decreased FMD ( &chi;2 = 9.26, P = 0.002) in MetS patients but not in the control group. Conclusions: Increased ox-LDL, hs-CRP, and e-NOS are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive nitrogen and oxygen species. In addition, in patients with MetS, smoking is independently related to endothelial dysfunctio

ENDOTHELIAL DYSFUNCTION MARKERS IN LOW CARDIOVASCULAR RISK INDIVIDUALS: COMPARISON OF MALES AND FEMALES

Background: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more attention. We hypothesized that differences in endothelial dysfunction biochemical markers among genders would aid to capture proatherogenic activity that was not diagnosed by conventional risk assessment scoring systems