Reconstruction of the sound radiation field from flexural vibration measurements with multiple cameras

This paper presents the background theory and the experimental implementation of a new approach for the reconstruction of the sound radiation field produced by the flexural vibration of a distributed structure using video image acquisitions. The study is focused on tonal flexural vibration and sound radiation at the first five resonance frequencies of a baffled flat rectangular plate model-structure. The plate is divided into a regular mesh of rectangular elements whose centres are marked with small bullets. The transverse vibrations at the grid of target points are estimated via triangulation from the images acquired with six cameras unevenly spread along half of a circle located, with a small offset, parallel to the surface of the plate. The sound radiation field in free space is then reconstructed from the Rayleigh integral, which is approximated into a finite sum over the mesh of elements. Both the flexural vibration field and the sound radiation field derived from the cameras video acquisitions are contrasted with measurements taken respectively with a laser vibrometer and an array of microphones

Recombinant Botulinum Neurotoxin Hc Subunit (BoNT Hc) and Catalytically Inactive Clostridium botulinum Holoproteins (ciBoNT HPs) as Vaccine Candidates for the Prevention of Botulism

There are few available medical countermeasures against botulism and the discontinuation of the pentavalent botulinum toxoid vaccine by the Centers for Disease Control and Prevention in 2011 has resulted in the need for a safe and effective prophylactic alternative. Advances in genetic engineering have resulted in subsequent vaccine efforts being primarily focused on the production of highly purified recombinant protein antigens representing one or more domains of the botulinum neurotoxin. Recombinant subunit vaccines based on the carboxy one-third of the toxin (Hc) developed in our lab against serotypes A-F have been shown to be safe and effective. However, in response to the identification of an ever increasing number of BoNT subtypes with significant amino acid heterogeneity, we have developed catalytically inactive BoNT holoproteins (ciBoNT HPs) in an attempt to elicit greater protective immunity to address these toxin variants. Here we report the production of ciBoNT/B1 HP, ciBoNT/C1 HP, ciBoNT/E1 HP and ciBoNT/F1 HP and compare the immunological and protective abilities of ciBoNT HPs and BoNT/A Hc, BoNT/B Hc, BoNT/C Hc, BoNT/E Hc and BoNT/F Hc vaccines when challenged with homologous and heterologous toxins. Our results suggest the ciBoNT HP vaccines exhibit superior potency after single vaccinations but multiple vaccinations with BoNT/Hc antigens resulted in increased survival rates at the toxin challenge levels used

José Angel Valente a quattro mani. I frammenti verso la lingua.

Nell'articolo viene preso in esame il ruolo della traduzione e dell'anonimato nel libro di José Ángel Valente "Fragmentos de un libro futuro", Barcelona, Galaxia Gutemberg-Círculo de Lectores, 2000