MOESM2 of Polyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors

Additional file 2. The data of NA inhibition experiments

Five macrocyclic glycosides from <i>Schoenoplectus tabernaemontani</i>

<p>Macrocyclic glycosides with unique 22-membered dimeric lactone skeleton, are rare occurring natural products. There are only ten compounds reported so far. Herein we reported the isolation and characterisation of five macrocyclic glycosides from <i>Schoenoplectus tabernaemontani</i>, including three new compounds (Schoenopolide A-C, <b>1–3)</b> and two known ones, Berchemolide (<b>4</b>) and Clemoarmanoside B (<b>5</b>). Their structures were established on the basis of extensive analysis of spectroscopic data. In addition, the anti-oxidative activity of Berchemolide (<b>4</b>) against H₂O₂-induced of renal tubular epithelial (HK-2) cells was also evaluated.</p

Access to 3a-Benzoylmethyl Pyrrolidino­[2,3‑<i>b</i>]­indolines via Cu^II-Catalyzed Radical Annulation/C3-Functionalization Sequence

A Cu^II-catalyzed radical annulation/C3-functionalization cascade of tryptamine derivatives with aryl ethylene is reported. The mild catalytic system enables the facile construction of 3a-benzoylmethyl­pyrrolidino­[2,3-<i>b</i>]­indolines with excellent chemo- and regioselectivities. Remarkably, this novel method utilizes earth-abundant and inexpensive cupric salt as the catalyst and air as the co-oxidant, rendering the process highly environmentally friendly and atom economic. Presumably, the reaction proceeds through Cu^II-initiated formation of pyrrolidino­[2,3-<i>b</i>]­indolines radical intermediate <b>I</b>, which is successively trapped by aryl ethylene and O₂ to form the product. An ¹⁸O₂-labeling experiment and several control experiments were designed to support the mechanistic proposal