Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

<div><p>In the presence of silver nanoparticles, fenoterol and orciprenaline were shown to enhance the chemiluminescence of the potassium periodate-luminol chemiluminescence system. Therefore, a new method for the determination of fenoterol and orciprenaline was developed. The catalytic effect of silver nanoparticles upon the reaction of potassium periodate and luminol was studied. The chemiluminescence characteristics of potassium periodate, luminal, and silver nanoparticles with fenoterol and orciprenaline were studied. Using univariate design, the factors influencing chemiluminescence were optimized. The optimal experimental conditions were 60 µmol L⁻¹ of potassium periodate, 80 µmol L⁻¹ of luminol, 6 mmol L⁻¹ of sodium hydroxide, 2 µmol L⁻¹ of silver nanoparticles, and a flow rate of 2.0 mL min⁻¹. The system permitted 200 injections per hour. The linear dynamic ranges were between 0.6 and 10 ng mL⁻¹ for fenoterol and 0.4 and 10 ng mL⁻¹ for orciprenaline, with limits of detection of 0.1 ng mL⁻¹ for fenoterol and 0.1 ng mL⁻¹ for orciprenaline. The method was successfully employed to determine fenoterol and orciprenaline with recoveries in the range of 97.5% to 99.9%. Chemiluminescence reaction mechanisms for these systems were proposed.</p></div

DataSheet_1_Case Report: sintilimab-induced Stevens-Johnson Syndrome in a patient with advanced lung adenocarcinoma.docx

Immune checkpoint inhibitors (ICIs) have been widely applicated in clinical therapy in recent years. Skin-related adverse reaction is one of the most common adverse events for ICIs. Stevens-Johnson syndrome (SJS) is one of the serious cutaneous reactions threatening the life. Here, we reported a case of 76-year-old male patient with poorly differentiated metastatic lung adenocarcinoma, after 9 weeks exposure of sintilimab (3 doses) combined with paclitaxel liposome after concurrent chemotherapy/radiotherapy, experienced Stevens-Johnson syndrome involving limbs, trunk, lip and the oral mucosa. Biopsy of the skin tissue showed infiltration of CD4 and CD8 positive T lymphocytes. We also found PD-L1 expression in the glands and the basal layer of the skin. This finding is distinct from the previously reported expression of PD-L1 on the surface of epidermal keratinocytes in patients with SJS due to immunotherapy.</p

Additional file 1: of Study on the Multi-level Resistance-Switching Memory and Memory-State-Dependent Photovoltage in Pt/Nd:SrTiO3 Junctions

Supporting information. (DOCX 154 kb

Reductive roasting of nickel laterite ore with sodium sulfate for Fe-Ni production. Part I: Reduction/sulfidation characteristics

<p>The selective reduction of nickel and adequate growth of ferronickel grains are imperative for efficient preparation of ferronickel from nickeliferous laterite ore via the process of direct reduction followed by magnetic separation. In Part I, reduction/sulfidation behaviors of a saprolitic laterite ore in the presence of sodium sulfate were investigated, with an emphasis on thermodynamic analysis, selective reduction/sulfidation ratios and kinetics. To separate the interactions between Ni and Fe, chemical titration analysis was adopted to determine the contents of various Ni and Fe species in the roasted pellets, and a modified equation to assay metallic iron content was proposed.</p

Table_1_Case Report: sintilimab-induced Stevens-Johnson Syndrome in a patient with advanced lung adenocarcinoma.docx

Immune checkpoint inhibitors (ICIs) have been widely applicated in clinical therapy in recent years. Skin-related adverse reaction is one of the most common adverse events for ICIs. Stevens-Johnson syndrome (SJS) is one of the serious cutaneous reactions threatening the life. Here, we reported a case of 76-year-old male patient with poorly differentiated metastatic lung adenocarcinoma, after 9 weeks exposure of sintilimab (3 doses) combined with paclitaxel liposome after concurrent chemotherapy/radiotherapy, experienced Stevens-Johnson syndrome involving limbs, trunk, lip and the oral mucosa. Biopsy of the skin tissue showed infiltration of CD4 and CD8 positive T lymphocytes. We also found PD-L1 expression in the glands and the basal layer of the skin. This finding is distinct from the previously reported expression of PD-L1 on the surface of epidermal keratinocytes in patients with SJS due to immunotherapy.</p

Highly Selective and Sensitive Electrochemical Immunoassay of Cry1C Using Nanobody and π–π Stacked Graphene Oxide/Thionine Assembly

Cry1C is one of the emerging toxin proteins produced by the <i>Bacillus thuringiensis</i> in the genetically modified crops for pest control in agriculture; thus, it is vital to measure the Cry1C level in crops for the healthy and environmental concerns. Current detections of Cry1C mainly rely on instrumental analysis such as high-performance liquid chromatography, which are time-consuming and are generally cost-prohibitive. Herein, a simple nanobodies (Nbs)-based electrochemical immunosensor has been first proposed for highly selective and sensitive detection of Cry1C. The Nbs pair, i.e., Nb51 and Nb54, which bind to different epitopes on Cry1C, was screened out from an immunized Bactrian camel, with an extra benefit of higher stability compared with conventional antibodies. Further, by using a π–π stacked graphene oxide/thionine assembly that had fast electron transfer kinetics as an electroactive label, the immunoreaction that occurred between the two Nbs and Cry1C can be highly sensitively quantified by square wave voltammetry. The linear detection range was from 0.01 to 100 ng·mL^–1, and the low detection limit was 3.2 pg·mL^–1. This method was further successfully applied for sensing Cry 1C in spiked samples with recoveries ranging from 100.17% to 106.69% and relative standard deviation less than 4.62%. This proposed assay would provide a simple highly sensitive and selective approach for the Cry1C toxin detection and be applicable to be extended to other toxin proteins sensing in foods

Application of Organometallic Chemistry to the Electrical Interconnection of Graphene Nanoplatelets

The formation of bis-hexahapto bonds between graphitic surfaces can electronically interconnect the surfaces of carbon materials containing the polybenzenoid ring system and increase the conductivity without introducing a strong perturbation to the in-plane electronic structure. In this paper, we report the use of organometallic chemistry to interconnect the surfaces of small scale graphene nanoplatelets by using a variety of metals and photochemically activated organometallic reagents

Relationship between size of uterine fibroid and obstetric outcomes.

<p>Relationship between size of uterine fibroid and obstetric outcomes.</p

Table_1_Gestational weight gain and pregnancy outcomes in Chinese women with type 2 diabetes mellitus: evidence from a tertiary hospital in Beijing.docx

ObjectiveTo examine the effects of gestational weight gain on pregnancy outcomes and determine the optimal range of weight gain during pregnancy for Chinese women with type 2 diabetes mellitus.MethodsThis retrospective cohort study included 691 Chinese women with type 2 diabetes mellitus from 2012 to 2020. The study utilized a statistical-based approach to determine the optimal range of gestational weight gain. Additionally, multivariate logistic regression analysis was conducted to assess the impact of gestational weight gain on pregnancy outcomes.Results(1) In the obese subgroup, gestational weight gain below the recommendations was associated with decreased risks of large for gestational age (adjusted odds ratio [aOR] 0.19; 95% confidence interval [CI] 0.06-0.60) and macrosomia (aOR 0.18; 95% CI 0.05-0.69). In the normal weight subgroup, gestational weight gain below the recommendations of the Institute of Medicine was associated with decreased risks of preeclampsia (aOR 0.18; 95% CI 0.04-0.82) and neonatal hypoglycemia (aOR 0.38; 95% CI 0.15-0.97). (2) In the normal weight subgroup, gestational weight gain above the recommendations of the Institute of Medicine was associated with an increased risk of large for gestational age (aOR 4.56; 95% CI 1.54-13.46). In the obese subgroup, gestational weight gain above the recommendations was associated with an increased risk of preeclampsia (aOR 2.74; 95% CI 1.02, 7.38). (3) The optimal ranges of gestational weight gain, based on our study, were 9-16 kg for underweight women, 9.5-14 kg for normal weight women, 6.5-12 kg for overweight women, and 3-10 kg for obese women. (4) Using the optimal range of gestational weight gain identified in our study seemed to provide better prediction of adverse pregnancy outcomes.ConclusionFor Chinese women with type 2 diabetes, inappropriate gestational weight gain is associated with adverse pregnancy outcomes, and the optimal range of gestational weight gain may differ from the Institute of Medicine recommendations.</p

Association between uterine fibroids and obstetric and delivery outcomes by multiple logistic regression.

<p>Association between uterine fibroids and obstetric and delivery outcomes by multiple logistic regression.</p