ENDOSURGICAL TREATMENT OF GALL-STONE DISEASE COMPLICATED BY CHOLEDOCHOLITHIASISAND DISTAL STRUCTURE OF COMMON BILE DUCT

The analysis of treatment of 67 patients with gall-stone disease complicated by choledocholithiasis and distal section stenosis of the common bile duct during the period from 2002 till 2007 is presented in the article. This group of patients took part in a research study of the single-stage method of treatment with laparoscopy has been preferably performed in this group of patients. The laparoscopy treatment techniques have been proved to be highly effectiv

Mechanisms of spinal motoneurons survival in rats under simulated hypogravity on earth

It was previously shown that different cell types in vivo and in vitro may die via apoptosis under weightlessness conditions in space as well as in simulated hypogravity on the Earth. We assessed survivability of spinal motoneurons of rats after 35-day antiorthostatic hind limb suspension. Following weight bearing, unloading the total protein content in lumbar spinal cord is dropped by 21%. The electrophysiological studies of m. gastrocnemius revealed an elevated motoneurons' reflex excitability and conduction disturbances in the sciatic nerve axons. The number of myelinated fibers in the ventral root of experimental animals was insignificantly increased by 35-day of antiorthostatic hind limb suspension, although the retrograde axonal transport was significantly decreased during the first week of simulated hypogravity. The results of the immunohistochemical assay with antibodies against proapoptotic protein caspase 9 and cytotoxicity marker neuron specific nitric oxide synthase (nNOS) and the TUNEL staining did not reveal any signs of apoptosis in motoneurons of suspended and control animals. To examine the possible adaptation mechanisms activated in motoneurons in response to simulated hypogravity we investigated immunoexpression of Hsp25 and Hsp70 in lumbar spinal cord of the rats after 35-day antiorthostatic hind limb suspension. Comparative analysis of the immunohistochemical reaction with anti-Hsp25 antibodies revealed differential staining of motoneurons in intact and experimental animals. The density of immunoprecipitate with anti-Hsp25 antibodies was substantially higher in motoneurons of the 35-day suspended than control rats and the more intensive precipitate in this reaction was observed in motoneuron neuritis. Quantitative analysis of Hsp25 expression demonstrated an increase in the Hsp25 level by 95% in experimental rats compared to the control. The immunoexpression of Hsp70 found no qualitative and quantitative differences in control and experimental lumbar spinal cords. Taken together our results show that (1) rat motoneurons survived after 35-day antiorthostatic hind limb suspension and the changes in neurons had a mostly functional character, and (2) the increased immunoexpression of Hsp25 can be considered as the anti-apoptotic factor. © 2009 Elsevier Ltd. All rights reserved

Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite

Experiments were conducted on male mice of the C57BL/6J for full genome study of gene expression. The animals were divided into two groups.The 'flight group' mice that had spent 30 days in space and the 'control group' mice that stayed on Earth. The spinal cord of the 'flight' group mice as extracted 14h following the biosatellite's landing. The spinal cord of the control group mice was extracted at the same time.Then the lumbar spinal cord was frozen in liquid nitrogen and kept until the beginning of the study at -80°C. Quality control of the feature was performed using the settings recommended by Agilent Technologies. Signal background was subtracted and the signal intensity of each gene was globally normalized using locally weighted scatterplot smoothing. The analysis suggests that various functional groups of genes in different types of cells in spinal cord may be involved in the development of HLS and some changes in gene expression certainly happened in motor neurons innervating affected skeletal muscles

Thermal regimes of HTS cylinders operating in devices for fault current limitation

We reveal obstacles related to the application of HTS cylinders in current limiting devices based on the superconducting - normal state transition. It is shown that, at the critical current density achieved presently in bulk materials, and especially in BSCCO-2212, the required thickness of the cylinder wall in a full-scale inductive device achieves several centimeters. A simple mathematical model of the operation of an inductive fault current limiter (FCL) is used to show that such cylinders cannot be cooled in admissible time after a fault clearing and, hence, the inductive FCLs and current-limiting transformers employing BSCCO cylinders do not return to the normal operation in the time required. For the recovery even with a non-current pause in the circuit, the cylinders are needed with the critical current density by an order higher than the existed ones.Comment: 15 pages, 5 figure

Studying the strategy on dental students’ perception of artworks by Ural artists and the role of this strategy in artistic and aesthetic development and education

To study the strategy on dental students’ perception of artworks by Ural artists and to assess its role in artistic and aesthetic development and education. The research was conducted at Dental Therapy and Propedeutics of Dental Disease Department of the Ural State Medical University (Ekaterinburg) in two steps. The research findings show the prevalence of the ulifen strategy and the Uvisualn strategy among the dental students. The review of the essay did not reveal any descriptions objectifying uassociative” strategy, “metaphorical” strategy or “impressive” strategy. Divided into sub-strategies, evaluation and differentiation of the strategy on dental students’ perception of artworks by Ural artists helps develop pedagogical approaches to artistic and aesthetic education as well define its role in developing a future thinking reflective clinician with a professional style of communication with patients and colleagues.Цель исследования - анализ стратегии восприятия полотен уральских художников студентами стоматологического факультета и изучение роли этой стратегии в художественно­эстетическом просвещении и воспитании. Работа выполнена на кафедре терапевтической стоматологии и пропедевтики стоматологических заболеваний УГМУ (Екатеринбург) в два этапа. Результаты исследования свидетельствуют о преобладании среди студентов стоматологического факультета «жизненной» и «изобразительной» стратегий. В ходе анализа эссе не выявлено описания «ассоциативной», <<метафорической» или «импрессивной» стратегии. Оценка и дифференциация стратегии восприятия полотен уральских художников студентами-стоматологами с выделением подстратегий позволяет построить педагогические подходы в художественно-эстетическом просвещении и определить его роль в воспитании думающего и мыслящего врача, клинициста, обладающего профессиональным стилем общения с пациентами и коллегами

Signatures of Molecular Unification and Progressive Oxidation Unfold in Dissolved Organic Matter of the Ob-Irtysh River System along Its Path to the Arctic Ocean

The Ob-Irtysh River system is the seventh-longest one in the world. Unlike the other Great Siberian rivers, it is only slightly impacted by the continuous permafrost in its low flow. Instead, it drains the Great Vasyugan mire, which is the world largest swamp, and receives huge load of the Irtysh waters which drain the populated lowlands of the East Siberian Plain. The central challenge of this paper is to understand the processes responsible for molecular transformations of natural organic matter (NOM) in the Ob-Irtysh river system along the South-North transect. For solving this task, the NOM was isolated from the water samples collected along the 3,000?km transect using solid-phase extraction. The NOM samples were further analyzed using high resolution mass spectrometry and optical spectroscopy. The obtained results have shown a distinct trend both in molecular composition and diversity of the NOM along the South-North transect: the largest diversity was observed in the Southern “swamp-wetland” stations. The samples were dominated with humic and lignin-like components, and enriched with aminosugars. After the Irtysh confluence, the molecular nature of NOM has changed drastically: it became much more oxidized and enriched with heterocyclic N-containing compounds. These molecular features are very different from the aliphatics-rich permafrost NOM. They witnesses much more conservative nature of the NOM discharged into the Arctic by the Ob-Irtysh river system. In general, drastic reduction in molecular diversity was observed in the northern stations located in the lower Ob flow

Personal hygiene innovations: clinical laboratory characteristics of a new calcium hydroxylapatite toothpaste

This paper presents the analysis of clinical laboratory and organoleptic properties of the new treatment and prophylactic toothpaste Dentaswiss Extra Whitening along with effects of its components on saliva and oral conditions. The study was carried out by the Ural State Medical University Department of Therapeutic Dentistry/ Propedeutics of Dental Decease and Department of General Chemistry along with the Ural Federal University Department of Control Systems Modeling on 30 volunteers from the students of the Faculty of Dentistry (average patient age was 20.6±1.76 years). The results of the course of Dentaswiss Extra Whitening toothpaste applied during 14 days demonstrated significant clinical effects with high cleansing (hygiene index reduction was 71%) and antiinflammatory capacity (PMA reduction was 72 %). The laboratory study data on physicochemical properties showed improved remineralizing properties of mixed saliva and tooth enamel restoration during the course of Dentaswiss Extra Whitening toothpaste. The organoleptic properties of the tested toothpaste were highly evaluated by the study participants for all parameters (scored 9.92±0.10).В статье представлена оценка клинико-лабораторных и органолептических характеристик новой лечебно-профилактической зубной пасты Dentaswiss Extra Whitening и воздействия ее компонентов на слюну и состояние полости рта. Исследование проведено на кафедре терапевтической стоматологии и пропедевтики стоматологических заболеваний, на кафедре общей химии ФГБОУ ВО УГМУ Минздрава России и на кафедре моделирования управляемых систем ФГАОУ ВО УрФУ у 30 пациентов-добровольцев из числа студентов стоматологического факультета (средний возраст пациентов составил 20,6±1,76 года). Результаты курсового применения ЗП Dentaswiss Extra Whitening на протяжении 14 дней выявили значительный клинический эффект с высоким очищающим (редукция ИГ — 71%) и противовоспалительным действием (редукция индекса РМА — 72%). Данные лабораторного исследования физико-химических свойств показали увеличение реминерализующих свойств смешанной слюны и восстановление эмали зубов при курсовом применении ЗП Dentaswiss Extra Whitening. Органолептические свойства исследуемой зубной пасты высоко оценены участниками исследования по всем параметрам (9,92±0,10 балла)

Vitamin d deficiency in young people as one of the factors leading to diseases of various body systems

The article deals the results of a survey of young patients with vitamin D3 deficiency. The dependence between the content of vitamin D3 and the state of various body's systems, including changes in the oral cavity, is studied.В статье рассмотрены результаты анкетирования молодых пациентов с недостаточностью и дефицитом витамина D. Исследована зависимость между содержанием витамина D и состоянием различных систем организма, включая состояние полости рта

Comparative assessment of efficiency ultrasonic and sound methods of activation irrigational solution in root channels with simple and difficult anatomy (pilot study)

The article presents a comparison of the effectiveness of ultrasonic and sound methods of activation of the solution at the stage of final irrigation.В статье представлено сравнение эффективности ультразвукового и звукового методов активации раствора на этапе финишной ирригации