Mining of nickel laterites – towards more environmentally responsible operations

Primary mining of technology metal ores is needed to enable effective decarbonisation. The use of nickel in rechargeable batteries is expected to increase global demand for nickel rapidly over the coming years. Over 60% of annual global nickel production originates from nickel laterites, with Indonesia and the Philippines leading the market. Mining of nickel laterite ore can adversely affect the environment through the release of CO2 and potentially hazardous elements (PHE), such as hexavalent chromium, or asbestiform minerals. Through our better understanding of the social and environmental impacts of mining operations and the availability of technologies that can potentially mitigate adverse impact, it is paramount to aim for more responsible mining and metal recovery operations. This study focuses on the Sta Cruz nickel laterite deposit in the Philippines. Through a multi-scale and multi-technique analytical programme and drawing on existing knowledge1,2, we appraise the deposit holistically, focusing on (i) the geochemistry and mineralogy of major commodities and trace metals, such as the platinum group elements; (ii) carbonate forming metals, e.g. magnesium and (iii) the presence and ecotoxicity of PHE and minerals. We use this understanding to assess the potential for a circular economy in mining, via complete utilisation of the ore to maximise the metal output and minimise the waste produced. This includes the removal of CO2 through the formation of carbonate minerals (mineral carbonation). We also investigate the potential of carbonates to immobilise chromium crystallographically alongside the CO2. This aspect of mineral carbonation is currently poorly understood. We have carried out laboratory synthesis of chromium-doped carbonates at ambient P-T conditions, which indicates that the most common magnesium carbonates do not readily accommodate chromium. However, other carbonate-bearing minerals, including those belonging to layered double hydroxides, present a viable alternative. The combined PHE-CO2 mineral carbonation, when implemented at different stages of metal recovery, from ore extraction to processing, could lead to a reduction of the volume and toxicity of waste, collectively contributing to the mitigation of the adverse environmental impact of nickel laterite mining. [1] Acquino et al (2022) Minerals, 12(3) [2] Bacuta et al (1990) Journal of Geochem.Exploration, 3

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

The Achievement of Personhood

The debate on personal identity tends to conflate or ignore two different usages of the word 'person'. Psychological-continuity proponents concentrate upon its use to refer to human psychology or personality, while animalist critics prefer its use to refer to individual human beings. I argue that this duality undermines any attempt to see 'person' as a genuine sortal term. Instead, adopting suggestions found in Dennett and Sellars, I consider personhood as an ascription rather like an honorific title or achievement-marker. I show how the questions of identity for a regular honorific title like 'genius' inevitably supervene on identity-questions concerning the more basic entity of 'person'. I then argue by analogy that, if 'person' be regarded as an honorific on a par with 'genius', questions of personal identity over time necessarily collapse into questions of the continuing identity of human beings. Attempts to separate the continuity of a person from that of the human being who embodies it then founder on conceptual and referential incoherencies. Room is left for increasing the extension of personhood ascriptions to non-humans in the future, while much that was previously puzzling about its behaviour as a concept is explained. At least some of the revisionist debate can now be seen more profitably as a debate about the moral and pragmatic considerations underlying non-paradigm human continuity

The trouble with thought experiments

What are thought experiments? What uses can they be put to and what problems do they face? In this paper I argue that thought experiments are hard to define and that they face significant problems when used as a tool to draw out our moral or conceptual intuitions. The role of the intuition in our philosophical and ethical lives is also problematic. I go on to argue that the more far-fetched thought experiments – and especially those that assume some kind of impossibility – face particular problems, and that here bioethics can learn from the effects of the prolific use of modally problematic thought experiments in other areas of philosophy, such as the personal identity debate. I argue that, as the personal identity debate can best be approached by testing our conceptual intuitions against real-life cases, so the same may be true of bioethics. But, whether we use thought experiments or real cases, we ought not to expect too much when seeking to apply concepts outside their standard range of application

Reducing Fuel Consumption on a Heavy-Duty Nonroad Vehicle: Conventional Powertrain Modifications

This investigation focuses on conventional powertrain technologies that provide operational synergy based on customer utilization to reduce fuel consumption for a heavy-duty, nonroad (off-road) material handler. The vehicle of interest is a Pettibone Cary-Lift 204i, with a base weight of 50,000 lbs. and a lift capacity of 20,000 lbs. The conventional powertrain consists of a US Tier 4 Final diesel engine, a non-lockup torque converter, a four-speed powershift automatic transmission, and all-wheel drive. The paper will present a base vehicle energy/fuel consumption breakdown of propulsion, hydraulic and idle distribution based on a representative end-user drive cycle. The baseline vehicle test data was then used to develop a correlated lumped parameter model of the vehicle-powertrain-hydraulic system that can be used to explore technology integration that can reduce fuel consumption. Two conventional powertrain modifications are explored that provide potential pathways that significantly alter the base powertrain and include 1.) a torque converter disconnect clutch and 2.) a low voltage stop-start system that have the potential to reduce fuel consumption on the end user representative drive cycle by 10.3% and 9.8%, respectively. Details of how the powertrain modifications would be executed, physical hardware, and application to other heavy-duty nonroad vehicle applications are included in the discussion