3 research outputs found
Reconstrução de polegar utilizando o segundo pododáctilo: Thumb reconstruction using the second pododactyl
Introdução: O polegar permite uma grande amplitude de movimentos essenciais para as atividades cotidianas. Portanto, a amputação traumática do primeiro quirodáctilo provoca um significativo comprometimento estĂ©tico e funcional. Nesses casos, a reconstrução do polegar utilizando dedo do pĂ© constitui-se como opção terapĂŞutica, devendo-se avaliar cada caso individualmente. Objetivos: Descrever e avaliar as tĂ©cnicas cirĂşrgicas realizadas em dois pacientes com transferĂŞncia do segundo pododáctilo para a mĂŁo devido Ă amputação traumática. Caso clĂnico: Dois pacientes do sexo masculino foram submetidos a cirurgias de reconstrução do polegar com transferĂŞncia do segundo pododáctilo para a mĂŁo numa clĂnica privada localizada na cidade de Fortaleza – Ceará. O primeiro paciente teve amputação total, inclusive do metacarpo, já o segundo teve amputação de falange mĂ©dia e distal. Em ambos os casos, utilizou-se o segundo pododáctilo para a reconstrução do polegar. No pĂłs-operatĂłrio tardio, os pacientes evoluĂram estĂ©tica e funcionalmente bem. Considerações finais: O transplante de dedos do pĂ© para a mĂŁo, em casos de trauma, como a amputação do polegar, apesar da sua complexidade e dos riscos de complicações, apresenta resultados estĂ©ticos e funcionais favoráveis ao paciente
IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study
Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients and its genetic polymorphisms may contribute to the aetiology and pathogenesis of disease in different ethnic groups. Polymorphisms in IL1β, IL18, NFKB1 and IFNG genes were studied in different populations with RA, but the analysis indicated contradictory results. Thereby, we hypothesised that polymorphisms in these genes could have a combined effect on susceptibility to and severity of disease. We evaluated the +3953 C/T IL1β (rs1143634), –137 G/C IL18 (rs187238), –94 ins/del ATTG NFKB1 (rs28362491) and +874 T/A IFNG (rs2430561) polymorphisms in the northeastern Brazilian population. Peripheral blood samples were collected and DNA extraction was conducted. The polymorphisms were evaluated by RFLP and ARMS–PCR. An association was observed in rs1143634 which showed a protective effect against development of RA in carriers of the T allele (OR = 0.58; 95% CI 0.36–0.92; p = .020). In addition, we found an association among genotypes of the rs1143634 with the HAQ index (p = .021) and rs2430561 with DAS28 (p = .029) and CDAI (p = .029). In relation to combined effects of these SNPs (C/C to rs1143634, G/G to rs187238, I/I to rs28362491 and AA to rs2430561) we found a significant association with decreased functional disability (HAQ index p < .001) and ESR (p = .034), indicating a lower disease activity in carriers of these genotypes. GLM analysis confirmed these associations (HAQ (F = 5.497; p < .001) and ESR (F = 2.727; p = .032)). Our analysis indicated that in the studied population +3953 C/T IL-1β (rs1143634), –137 G/C IL-18 (rs187238), –94 ins/del ATTG NFKB1 (rs28362491) and +874 T/A IFNG (rs2430561) polymorphisms can together contribute to RA severity although they do not individually influence the disease
NĂşcleos de Ensino da Unesp: artigos 2008
Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq