Spectral Pattern Analysis of Propofol Induced Spindle Oscillations in the Presence of Auditory Stimulations

This study’s primary objective is to analyze human EEG spindle oscillations during propofol-induced anesthesia and to address possible activation sources. Such an analysis also has a secondary role of investigating the short- term spectral patterns and their functional role

Brain function assessment in different conscious states

Background: The study of brain functioning is a major challenge in neuroscience fields as human brain has a dynamic and ever changing information processing. Case is worsened with conditions where brain undergoes major changes in so-called different conscious states. Even though the exact definition of consciousness is a hard one, there are certain conditions where the descriptions have reached a consensus. The sleep and the anesthesia are different conditions which are separable from each other and also from wakefulness. The aim of our group has been to tackle the issue of brain functioning with setting up similar research conditions for these three conscious states.Methods: In order to achieve this goal we have designed an auditory stimulation battery with changing conditions to be recorded during a 40 channel EEG polygraph (Nuamps) session. The stimuli (modified mismatch, auditory evoked etc.) have been administered both in the operation room and the sleep lab via Embedded Interactive Stimulus Unit which was developed in our lab. The overall study has provided some results for three domains of consciousness. In order to be able to monitor the changes we have incorporated Bispectral Index Monitoring to both sleep and anesthesia conditions.Results: The first stage results have provided a basic understanding in these altered states such that auditory stimuli have been successfully processed in both light and deep sleep stages. The anesthesia provides a sudden change in brain responsiveness; therefore a dosage dependent anesthetic administration has proved to be useful. The auditory processing was exemplified targeting N1 wave, with a thorough analysis from spectrogram to sLORETA. The frequency components were observed to be shifting throughout the stages. The propofol administration and the deeper sleep stages both resulted in the decreasing of N1 component. The sLORETA revealed similar activity at BA7 in sleep (BIS 70) and target propofol concentration of 1.2 μg/mL.Conclusions: The current study utilized similar stimulation and recording system and incorporated BIS dependent values to validate a common approach to sleep and anesthesia. Accordingly the brain has a complex behavior pattern, dynamically changing its responsiveness in accordance with stimulations and states. © 2010 Ozgoren et al; licensee BioMed Central Ltd

Tele-Intensive Care and the Current Situation in Turkey, Opportunities, Restrictions

Intensive care treatment needs and costs are expected to increase with the ageing population in our country and the world. Tele-intensive care unit (Tele-ICU) applications can provide an alternative solution to treat and follow up critical patients remotely. It can help use existing resources efficiently. With the Tele-ICU program, intensive care specialists will reach all intensive care beds in the country without restrictions. They will evaluate the patients' situations with all data from electronic recording systems. However, problems with some legal regulations or terms of job descriptions, deterioration of patient-doctor, doctor-patient's relative relationships, or some infrastructure deficiencies when using the Tele-ICU system could override the potential benefit of the new solution strategy. This review was written to inform about Tele-ICU, draw attention to opportunities, shortcomings, and limitations if Tele-ICU is applied in our country, and ensure that the necessary steps are taken to resolve these deficiencies

Modified Multiple Block Design: Memory Measurements in Anesthesia

Aim: The memory processes in regard to anesthesia is currently an open debate. Naturally there are two conditions behind this concern; firstly whether if the anesthesia would cause some memory loss; secondly but quite the opposite, whether if during anesthesia some unwanted events could be remembered. Accordingly the study aims to assess the memory relationship of pre-, during and post-anesthesia processes

Analyzing Exposures to Electromagnetic Fields in an Intensive Care Unit

Objective: In this study, we conducted a numerical analysis of exposure to electromagnetic fields (EMFs) in a hospital's intensive care unit that is one of the most crucial one in terms of hazardous areas among all service units. This is a new study for measuring exposure to EMFs in an intensive care unit as well as other healthcare services in Turkey

The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity.

Background: Accidental intravenous exposure to bupivacaine is highly cardiotoxic and may lead to death. Positive inotropic agents are usually utilized in resuscitative efforts. We have compared the efficacy of levosimendan, a novel inotropic agent, with dobutamine and their combination in a rat model of bupivacaine intoxication

THE EFFECT OF APPLICATION OF LOCAL OXIDISED CELLULOSE POWDER ON HEMOSTASIS TIME IN A RAT MODEL WITH FEMORAL ARTERY BLEEDING

Aims: Whether pre-hospital area or emergency department, the early diagnosis and control of bleeding is the first critical step in the treatment of trauma patients. This becomes increasingly critical as the victim-to-medical-personnel or equipment ratio becomes higher (disasters, wars and/or mass casualty events e.g.). We purposed to investigate the hemostatic effect of application of local oxidised cellulose powder on time to hemostasis time in a rat model with severe femoral artery bleeding