5 research outputs found
An Effective Ethnobotanical Medicine Against Hemiplagia
Volume: 98Start Page: 321End Page: 32
Toluene Dioxygenase Catalysed synthesis and reactions of cis-diol metabolites derived from 2 and 3-methoxy phenols
Toluene Dioxygenase-Catalyzed Synthesis and Reactions of <i>cis</i>-Diol Metabolites Derived from 2- and 3‑Methoxyphenols
Using
toluene dioxygenase as biocatalyst, enantiopure <i>cis</i>-dihydrodiol and <i>cis</i>-tetrahydrodiol metabolites,
isolated as their ketone tautomers, were obtained from <i>meta</i> and <i>ortho</i> methoxyphenols. Although these isomeric
phenol substrates are structurally similar, the major bioproducts
from each of these biotransformations were found at different oxidation
levels. The relatively stable cyclohexenone <i>cis</i>-diol
metabolite from <i>meta</i> methoxyphenol was isolated,
while the corresponding metabolite from <i>ortho</i> methoxyphenol
was rapidly bioreduced to a cyclohexanone <i>cis</i>-diol.
The chemistry of the 3-methoxycyclohexenone <i>cis</i>-diol
product was investigated and elimination, aromatization, hydrogenation,
regioselective <i>O</i>-exchange, Stork–Danheiser
transposition and <i>O</i>-methylation reactions were observed.
An offshoot of this technology provided a two-step chemoenzymatic
synthesis, from <i>meta</i> methoxyphenol, of a recently
reported chiral fungal metabolite; this synthesis also established
the previously unassigned absolute configuration
Cardiolipin and Mitochondrial Phosphatidylethanolamine Have Overlapping Functions in Mitochondrial Fusion in Saccharomyces cerevisiae
Abstracts of Scientifica 2022
This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference.
Conference Title: Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi