An Effective Ethnobotanical Medicine Against Hemiplagia

Volume: 98Start Page: 321End Page: 32

Toluene Dioxygenase-Catalyzed Synthesis and Reactions of <i>cis</i>-Diol Metabolites Derived from 2- and 3‑Methoxyphenols

Using toluene dioxygenase as biocatalyst, enantiopure <i>cis</i>-dihydrodiol and <i>cis</i>-tetrahydrodiol metabolites, isolated as their ketone tautomers, were obtained from <i>meta</i> and <i>ortho</i> methoxyphenols. Although these isomeric phenol substrates are structurally similar, the major bioproducts from each of these biotransformations were found at different oxidation levels. The relatively stable cyclohexenone <i>cis</i>-diol metabolite from <i>meta</i> methoxyphenol was isolated, while the corresponding metabolite from <i>ortho</i> methoxyphenol was rapidly bioreduced to a cyclohexanone <i>cis</i>-diol. The chemistry of the 3-methoxycyclohexenone <i>cis</i>-diol product was investigated and elimination, aromatization, hydrogenation, regioselective <i>O</i>-exchange, Stork–Danheiser transposition and <i>O</i>-methylation reactions were observed. An offshoot of this technology provided a two-step chemoenzymatic synthesis, from <i>meta</i> methoxyphenol, of a recently reported chiral fungal metabolite; this synthesis also established the previously unassigned absolute configuration

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi