80 research outputs found
Dehydrogenative Synthesis of Imines from Alcohols and Amines Catalyzed by a Ruthenium N-Heterocyclic Carbene Complex
TBHPâInitiated Transamidation of Secondary Amides via CâN Bond Activation: A MetalâFree Approach
Transition-Metal-Free CâH Hydroxylation of Carbonyl Compounds
Transition metal
and reductant free Îą-CÂ(sp3)âH hydroxylation
of carbonyl compounds are reported. This method is promoted by commercially
available inexpensive KO-<i>t</i>-Bu and atmospheric air
as an oxidant at room temperature. This unified strategy is also very
facile for hydroxylation of various carbonyl compound derivatives
to obtain quaternary hydroxyl compounds in excellent yield. A preliminary
mechanistic investigation, supported by isotope labeling and computational
studies, suggests the formation of a peroxide bond and its cleavage
by in situ generated enolate
Transition-Metal-Free CâH Hydroxylation of Carbonyl Compounds
Transition metal
and reductant free Îą-CÂ(sp3)âH hydroxylation
of carbonyl compounds are reported. This method is promoted by commercially
available inexpensive KO-<i>t</i>-Bu and atmospheric air
as an oxidant at room temperature. This unified strategy is also very
facile for hydroxylation of various carbonyl compound derivatives
to obtain quaternary hydroxyl compounds in excellent yield. A preliminary
mechanistic investigation, supported by isotope labeling and computational
studies, suggests the formation of a peroxide bond and its cleavage
by in situ generated enolate
Unravelling the role of microorganisms in arsenic mobilization using metagenomic techniques
The contamination of groundwaters, abstracted for drinking and irrigation, by sediment-derived arsenic, threatens the health of tens of millions worldwide. Microbial processes are accepted as playing a key role in arsenic mobilisation from sediments into groundwaters, but the precise biogeochemical mechanisms remain a subject of debate. A combination of field investigations, coupled to laboratory experimentation with sediment samples using âmicrocosmâ approaches, has provided a significant body of evidence supporting a key role for anaerobic metal-reducing bacteria in the reductive mobilization of arsenic in aquifers in West Bengal, Cambodia, Vietnam and Bangladesh. The application of high-throughput next generation sequencing, combined with metagenomic reconstructions and other âomicsâ techniques from the life sciences is shedding new insight into the processes at play, and identifying new mircoorganisms and coupled biogeochemical processes that control the solubility of arsenic in Asian aquifers
Manganese-Catalyzed Synthesis of Quaternary Peroxides: Application in Catalytic Deperoxidation and Rearrangement Reactions
Iron-Catalyzed Batch/Continuous Flow CâH Functionalization Module for the Synthesis of Anticancer Peroxides
Iron-catalyzed
dehydrogenative cross-coupling of carbonyl compounds
with aliphatic peroxide was developed under mild conditions. A library
of linear alkylated and arylated peroxides are synthesized in good
to excellent yield. This method is highly selective and general for
a range of biologically important derivatives of 2-oxindole, barbituric
acid, and 4-hydroxy coumarin with a good functional group tolerance
and without the cleavage of the peroxide bond. This peroxidation reaction
is upscalable to grams and also synthesizable in continuous flow with
increased safety in short duration. Mechanistic investigation reveals
Fe-(II) undergoes redox type process to generate the radical intermediates,
which subsequently recombine selectively to form the stable peroxides.
The potential of peroxides is evaluated by cell viability assay and
found to exhibit the good anticancer activity with minimum IC<sub>50</sub>= 5.3 ÎźM
Iron-Catalyzed Batch/Continuous Flow CâH Functionalization Module for the Synthesis of Anticancer Peroxides
Iron-catalyzed
dehydrogenative cross-coupling of carbonyl compounds
with aliphatic peroxide was developed under mild conditions. A library
of linear alkylated and arylated peroxides are synthesized in good
to excellent yield. This method is highly selective and general for
a range of biologically important derivatives of 2-oxindole, barbituric
acid, and 4-hydroxy coumarin with a good functional group tolerance
and without the cleavage of the peroxide bond. This peroxidation reaction
is upscalable to grams and also synthesizable in continuous flow with
increased safety in short duration. Mechanistic investigation reveals
Fe-(II) undergoes redox type process to generate the radical intermediates,
which subsequently recombine selectively to form the stable peroxides.
The potential of peroxides is evaluated by cell viability assay and
found to exhibit the good anticancer activity with minimum IC<sub>50</sub>= 5.3 ÎźM
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