Sample Sizes and Geographic Origins of Samples

<p>The latitudes and longitudes used for the various groups are given in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020215#pgen-0020215-st002" target="_blank">Table S2</a>.</p

Mean <i>F_st</i> Values for Each Indian Group across Comparisons with 18 Populations from East Asia, 12 Populations from Europe and the Middle East, and the Other 14 Groups from India

<div><p>(A) 715 microsatellites.</p><p>(B) 207 indels.</p><p>Error bars denote standard deviations across comparisons.</p></div

Cumulative Distribution Function for the Absolute Allele Frequency Difference between Various Populations and (Non-Gujarati) Indians

<div><p>(A) All alleles at 715 microsatellites.</p><p>(B) All alleles at 207 indels.</p><p>(C) Common alleles at 715 microsatellites (alleles whose frequencies average more than 0.05 in the two groups).</p><p>(D) Common alleles at 207 indels (alleles whose frequencies have a mean above 0.05 and below 0.95 in the two groups).</p></div

Comparison of Allele Frequencies in India to Allele Frequencies in East Asia and Europe/Middle East

<div><p>(A) East Asia, 8,618 alleles at 715 microsatellites.</p><p>(B) East Asia, 414 alleles at 207 indels.</p><p>(C) Europe/Middle East, 8,618 alleles at 715 microsatellites.</p><p>(D) Europe/Middle East, 414 alleles at 207 indels.</p></div

Correlation Coefficient of Allele Frequencies in India with Linear Combinations of the Allele Frequencies in Europe and East Asia, as a Function of the Fraction of the Linear Combination Drawn from Europe

<p>Graphs with “all populations” compare the frequencies in the pooled Indian sample with linear combinations of the pooled European/Middle Eastern sample and the pooled East Asian sample; graphs with “larger populations” exclude the Parsi group from the Indian sample and utilize only the pooled French, Italian, and Russian genotypes in Europe and the pooled Han Chinese and Japanese genotypes in East Asia. The maxima of the four graphs, from top to bottom, occur at (0.685, 0.967), (0.656, 0.957), (0.679, 0.918), and (0.654, 0.898), respectively. The analysis considers all alleles found worldwide at the 715 microsatellites and 207 indels.</p

Relationship of <i>F_st</i> and Geographic Distance for Pairs of Groups from India

<div><p>(A) 715 microsatellites (correlation coefficient of −0.10 [<i>p</i> = 0.32], or 0.09 [<i>p</i> = 0.41] if comparisons involving the Parsi group are excluded).</p><p>(B) 207 indels (correlation coefficient of −0.02 [<i>p</i> = 0.84], or 0.28 [<i>p</i> = 0.007] when excluding comparisons involving the Parsi group). </p><p>A complete list of pairwise values of <i>F_st</i> is contained in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020215#pgen-0020215-st003" target="_blank">Table S3</a>.</p></div