Factor Correspondence Analysis comparing different individuals from different Ogliastra villages, performed with 5,192 SNPs.

<p>Each individual is represented by a circular shape, and the different 8 communities are marked with different colours. The two plots represented factor 1 and 2 and factor 1 and 3. (A1, A2) Analysis performed with 8 communities; (B1, B2) Analysis performed with 6 communities, without Talana and Urzulei.</p

Endogamy (values in %) in the Ogliastra villages from 1676 to 1975.

<p>Endogamy (values in %) in the Ogliastra villages from 1676 to 1975.</p

Population growth in the 8 villages analyzed starting from the 17^th century to the year 2001.

<p>Population growth in the 8 villages analyzed starting from the 17^th century to the year 2001.</p

On the left, geographic localization of Ogliastra region in Sardinia.

<p>On the right, detailed location of the 8 villages analyzed.</p

Fst values computer for each pair-wise comparison calculated on 5262 SNPs evenly spaced on 500 Kb. Corresponding 95% confidence intervals, shown between parentheses, were determined with permutations testing (set at 1000).

<p>The levels of statistical significance were tested by performing 1000 permutations. All comparisons were highly significant (P<10⁻³).</p

Distribution of Linkage Disequilibrium on chromosome 22.

<p>Average D' (A) and r² (B) coefficients plotted in 0.5 Megabases sliding windows (0.25 Mb overlap).</p

For each village we report resident population size, average village kinship values, number of samples and its average kinship values.

<p>For each village we report resident population size, average village kinship values, number of samples and its average kinship values.</p

Comparison of population-specific LD maps on chromosome 22 of the 10 samples from Ogliastra villages, rest of Sardinia and CEU.

<p>Comparison of population-specific LD maps on chromosome 22 of the 10 samples from Ogliastra villages, rest of Sardinia and CEU.</p

Genetic distance as a function of geographic distance between each pair of communities.

<p>On the left (A) Mantel Test plot analysis using SNPs data; on the right (B) Mantel Test plot analysis using Haplotype data.</p

STRUCTURE results under the assumption of different population groups (K = 2:8).

<p>Each individual is shown as a vertical line partitioned into K colored components representing inferred membership in K genetic clusters. K  =  7 represents the highest values of lnP(D).</p