Latinos and Affirmative Action

This issue brief will discuss Latinos and their involvement with affirmative action. This issue brief will also highlight the positive correlation of wealth and education and subsequently show that Latinos are disproportionately disadvantaged

European Americans and Socio-Economic Status

This issue brief details the socio-economic status of European Americans relative to minorities. This status is established in terms of income, educational rates, and incarceration rates. It also notes the prediction of the change in U.S. population—specifically the increase in the Latino population

Compaction Grouting for Seismic Retrofit of the North Torrey Pines Bridge

The North Torrey Pines Road Bridge in Del Mar, California was built in 1933 and is eligible for listing in the National Register of Historic Places. As a result of its outdated design and deterioration in a corrosive saline environment, the bridge was classified as structurally and seismically deficient and functionally obsolete. The historic significance of this bridge is important to the surrounding community and thus a seismic retrofit project was initiated with the goal of improving the expected seismic performance of the bridge while preserving its aesthetic and historic character. This paper provides a brief description of the overall retrofit design strategy, and detailed descriptions of the design of compaction grouting ground improvement to mitigate liquefaction and seismic slope instability hazards. Techniques used in the compaction grouting construction are presented, along with some particular construction challenges and solutions. Pre- and post-construction Standard Penetration Test data are compared and the improvements to the soil are discussed. The compaction grouting program was successful in achieving the ground improvement levels required by the design

Designing K-12th technology training : technology mentoring program

The purpose of this project was to provide a curriculum and framework for a technology-mentoring program at Dike-New Hartford Community School District, a rural school district in Eastern Iowa. Taking a different approach to technology training, this program was designed to help remove barriers that keep teachers from integrating technology throughout their content area. These proactive steps included: • Creating mentoring groups to provide long-term support for technology integration. • Providing teachers with personal laptops and current software. • Providing paid technology training outside of school hours. • Introducing easy-to-use technology tools that can be quickly integrated. The goal of this project was to create a subculture of technology use throughout the school district, starting with building-level technology leaders. Using the Iowa Professional Development Model as a guide, this mentoring program included ongoing support to help narrow the gap between technology training and actual classroom integration

Characterizing Bighorn Sheep Foraging Sites Using the Modified Robel Pole in the Southern Black Hills, South Dakota

Evaluating foraging behavior of bighorn sheep (Ovis canadensis) and filling information gaps for their habitat requirements is important for population level management in the southern Black Hills of South Dakota. Our objectives were to: (1) evaluate the overall summer foraging area post lambing use during July and August for standing herbage with the modified Robel pole (1.27 cm bands) with visual obstruction readings (VOR) related to clipped herbage at ground level; (2) calibrate the Robel pole visual obstruction (bands) with clipped vegetation; and (3) develop guidelines for monitoring the landscape of the bighorn sheep foraging areas. The study area is located in a ponderosa pine (Pinus ponderosa ) savanna with few shrubs and dominated with native grasses. Each transect had 10 visual obstruction (bands) stations spaced 10 meters apart with 4 visual obstruction readings at each station. At 4 stations, total vegetation was clipped at ground level within a 0.25-m2  circular hoop. Clipped standing herbage ranged from 418 kg/ha to 3731 kg/ha with a mean of 1519 kg/ha. VOR measurements ranged from 0.2 cm to 14.9 cm with a 3.9 cm mean. Calibration of the modified Roble pole (visual obstruction of bands) with transect means using linear regression reliability predicted average clipped standing herbage (dry weights) within the bighorn sheep foraging area. The relationship was significant (R2  = 0.65; F1, 27  = 50.75, P  < 0.01). Cluster analysis (ISODATA) applied to the pole readings (VOR) and herbage resulted in 3 categories: short, intermediate and tall. We recommend 14 Robel pole transects (100 m in length) for VOR measurements within key foraging areas for future monitoring of herbaceous biomass for bighorn sheep. Foraging sites were in areas with little overstory tree canopy, close to rocky escape terrain, and where abundant grasses and forbs had little woody debris. The modified Robel pole provides a simple, reliable and cost effective alternative to clipping vegetation and obtaining dry weights

Accumulation of Maize chlorotic dwarf virus proteins in its plant host and leafhopper vector

AbstractThe genome of Maize chlorotic dwarf virus (MCDV; genus Waikavirus; family Sequiviridae) consists of a monopartite positive-sense RNA genome encoding a single large polyprotein. Antibodies were produced to His-fusions of three undefined regions of the MCDV polyprotein: the N-terminus of the polyprotein (R78), a region between coat proteins (CPs) and the nucleotide-binding site (NBS) (R37), and a region between the NBS and a 3C-like protease (R69). The R78 antibodies react with proteins of 50 kDa (P50), 35 kDa (P35), and 25 kDa (P25) in virus preparations, and with P35 in plant extracts. In extracts of the leafhopper vector Graminella nigrifrons fed on MCDV-infected plants, the R78 antibodies reacted with P25 but not with P50 and P35. The R69 antibodies bound proteins of approximately 36 kDa (P36), 30 kDa (P30), and 26 kDa (P26) in virus preparations, and P36 and P26 in plant extracts. Antibodies to R37 reacted with a 26-kDa protein in purified virus preparations, but not in plant extracts. Neither the R69 nor the R37 antibodies bound any proteins in G. nigrifrons. Thus, in addition to the three CPs, cysteine protease and RNA-dependent RNA polymerase, the MCDV polyprotein is apparently post-transitionally cleaved into P50, P35, P25, P36, P30, and P26

Vedolizumab: an α4β7 integrin antagonist for ulcerative colitis and Crohn’s disease

Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic, relapsing inflammatory bowel diseases associated with significant morbidity. Conventional therapies for these diseases include corticosteroids, aminosalicylates, immunomodulators, and monoclonal antibodies. Over the years tumor necrosis factor (TNF)-α antagonists alone or in combination with other therapies have emerged as the cornerstone of treatment for induction and maintenance of remission of moderate to severe UC and CD. Unfortunately, some patients with moderate to severe UC and CD are unable to attain or maintain remission with TNF-α antagonist treatment. Vedolizumab, a humanized monoclonal antibody, is the first integrin receptor antagonist approved that selectively antagonizes α4β7 gastrointestinal integrin receptors. US Food and Drug Administration approval is for treatment of patients with moderate to severe active UC and CD who have inadequate response with, lost response to, or are intolerant to a TNF-α antagonist or an immunomodulator; or have inadequate response with, are intolerant to, or demonstrate dependence on corticosteroids. When administered according to approved dosing in patients with moderate to severe CD and UC, vedolizumab induces clinical response rates up to 31.4% and 47.1% at week 6, and clinical remission rates up to 39% and 41.8% at week 52, respectively. Serious adverse events reported with vedolizumab include serious infections, malignancies, and anaphylaxis. Since vedolizumab is gastrointestinal selective, to date, it has not shown evidence of causing progressive multifocal leukoencephalopathy; however, postmarketing studies monitoring for this adverse effect are ongoing. Further assessment of vedolizumab earlier in the course of these diseases and in combination with other therapies is warranted

General Report - Session 6

This general report provides a summary of 40 accepted papers submitted to sessions 6a on ground improvement methods and session 6b on geoenvironmental engineering. The papers are contributed by the researchers and professionals from the United States and 15 other countries and they cover a wide range of topics based on laboratory experiments, field design, construction and monitoring, and mathematical modeling. A brief summary of each paper is provided under organized sections and the reader is referred to consult the full paper for details. Finally, the topics for discussion are listed