Experimental and Clinical Cardiac Beta-receptor Studies

PET imaging may provide new insights in in vivo changes of cardiac beta-adrenoceptors. Using 11C-CGP12177 and PET (CGP-PET) with standardized reorientation to 10 short axis slices, changes in beta-receptor distribution e.g. due to myocardial infarction and ischemia may be better identified and characterized. Because of its non-invasive character, PET also provides the possibility of serial measurements, and may elucidate the effect of different treatment strategies on cardiac beta-adrenoceptor density in several heart disases