6 research outputs found
Paper Session III-B - Wavelength- Division Multiplex of Bipolar Digital Signals for Digital Fiber Optic Transmission
Deterioration of the Kennedy Space Center Launch Processing System copper data bus cables over time, combined with the unavailability of replacement cabling and the transmission distances of 10 kilometers, resulted in the decision to replace the copper cable system with a fiber optic version. The replacement system is referred to as the Digital Fiber Optic Transmission Equipment. The distinguishing aspect of the digital Fiber Optic Transmission Equipment is the use of Wavelength Division Multiplexing fiber optic technology. This design allows the transmission of digital bipolar data on a single fiber optic cable. This paper describes the system requirements and design characteristics of Digital Fiber Optic Transmission Equipment using Wavelength Division Multiplexing technology for the transmission of digital bipolar data on a single fiber optic cable
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The contribution of X-linked coding variation to severe developmental disorders
Abstract: Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders
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Out of sight: problem sequences and epistemic boundaries of medical know-how on glaucoma
Innovation, Growth of knowledge, Problem sequences, Medicine, O33, I11, D83, D85,