Abeliaside, a new phenolic glucoside from <i>Abelia triflora</i>

<p>A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4′-tetrahydroxy flavones, caffeic acid, 4-<i>O</i>-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of <i>Abelia triflora</i> R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds <b>1</b>–<b>5</b> were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC₅₀: 17 μg/mL) and PC-3 (IC₅₀: 20.1 μg/mL) compared to vinblastine sulphate as reference drug (IC₅₀: 4.6, 2.8 μg/mL). The other compounds showed weak anticancer activity on both cell lines.</p

New flavonol glycosides from the leaves of <i>Caragana brachyantha</i>

<div><p>Two new flavonol glycosides, brachysides C and D, together with three known flavonol glycosides, were isolated from the leaves of <i>Caragana brachyantha</i>. The structures of brachysides C and D were elucidated on the basis of detailed spectroscopic analysis as quercetin 5-<i>O</i>-[α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside]-7-<i>O</i>-[α-l-rhamnopyranoside] and quercetin 5-<i>O</i>-[α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside]-7-<i>O</i>-[α-l-rhamnopyranoside]-4′-<i>O</i>-[α-l-rhamnopyranoside], respectively. The presence of flavonol tetra- and triglycosides bearing a sugar moiety at position 5 was the first report from this genus <i>Caragana</i>.</p></div