The Influence of Transrectal Multifocal Prostate Biopsy Under Ultrasound Control on the Degree of Infravesical Obstruction in Different Groups of Patients

. Prostate cancer - is a Malignant neoplasm arising from prostatic epithelium. [1] It is well known, that prostate cancer is the most common cancer in men population. Most patients, who underwent a biopsy of prostate, have expressed varying degrees of benign prostatic hyperplasia and, accordingly, symptoms, specific to the disease, including symptoms of the lower urinary (LUTS). [2], Uroflowmetry is a method widely used around the world to assess the degree of severity of infravesical obstruction [3].The aim was to determine the degree of influence of transrectal multifocal biopsy of the prostate under ultrasound control on the degree of infravesical obstruction [4].The study included patients with elevated serum PSA over 4 ng/ml with the volume (Vpr) of prostate from 20 cm³ to 90 cm³, volume of residual urine no more than 50 cm ³. Uroflowmetry was performed with the determination of the volume of residual urine at the primary treatment. At 21 day after transrectal multifocal prostate biopsy under Ultrasound control all patients underwent uroflowmetry. The age of patients ranged from 40 to 70 years. Patients were divided into 3 groups depending on the volume of the prostate gland. The first group consisted of 28 people where prostate volume ranged from 20 cm³ to 40 cm³, in the second group, consisted of 25 persons, prostate volume ranged from 41 cm³ to 60 cm³, and in the third group, consisted of 30 people, prostate volume ranged from 61 cm³ to 90 cm³. The following indicators of urofloumetry were determined as the following: voided volume, max flow rate, average flow, voiding time, flow time, time to max flow, and the volume of residual urine.This study has demonstrated a high risk of complications in patients with prostate volume of more than 60 cm3 caused by infravesical obstruction after prostate biopsy

Minimally Invasive Urological Interventions in Outpatient Clinic on the Example of Prostate Biopsy

One of the main directions of improving medical care was the introduction of inpatient forms of medical care for patients who do not require round-the-clock supervision.Aim of the research: to prove the effectiveness and economic feasibility of minimally invasive procedures in outpatient conditions.Materials and methods. The study included 3524 patients in the period from 2010 to 2017, who underwent transrectal prostate biopsy on the basis of the Department of urology of polyclinic No. 195 of the Western district of Moscow. For comparison, the patients were taken, who underwent a biopsy of the prostate gland at the base hospital No. 31, No. 51, No. 17.Results. The average number of biopsies performed in hospital No. 31, No. 51 and No. 17 for the year amounted to 344 biopsies, and the average detectability of prostate cancer was 142 (41.3 %). The average number of biopsies per year in the urology department of the branch number 2 GP No. 195 amounted to 440.5, and the average detectability of prostate cancer – 152.8 (34.7 %). Thus, with comparable inpatient detection of prostate cancer in one large outpatient urology center, an average of 28 % more biopsies are performed (440.5 versus 344) than in 3 hospitals over a comparable period of time.Conclusions. Inpatient technologies can reduce the burden on hospitals. The development of hospital-replacing forms is determined by the need of the population and for efficient use of financial and technical resources of health care

New Perturbation Theory for Nonstationary Anharmonic Oscillator

The new perturbation theory for the problem of nonstationary anharmonic oscillator with polynomial nonstationary perturbation is proposed. As a zero order approximation the exact wave function of harmonic oscillator with variable frequency in external field is used. Based on some intrinsic properties of unperturbed wave function the variational-iterational method is proposed, that make it possible to correct both the amplitude and the phase of wave function. As an application the first order correction are proposed both for wave function and S-matrix elements for asymmetric perturbation potential of type $V(x,\tau)=\alpha (\tau)x^3+\beta (\tau)x^4.$ The transition amplitude ''ground state - ground state'' $W_{00}(\lambda ;\rho)$ is analyzed in detail depending on perturbation parameter $\lambda$ (including strong coupling region $$ $\sim 1$) and one-dimensional refraction coefficient $\rho$.Comment: LaTeX, 13 page

Theoretical and Numerical Study of Self-Organizing Processes in a Closed System Classical Oscillator and Random Environment

A self-organizing joint system classical oscillator–random environment is considered within the framework of a complex probabilistic process that satisfies a Langevin-type stochastic differential equation. Various types of randomness generated by the environment are considered. In the limit of statistical equilibrium (SEq), second-order partial differential equations (PDE) are derived that describe the distribution of classical environmental fields. The mathematical expectation of the oscillator trajectory is constructed in the form of a functional-integral representation, which, in the SEq limit, is compactified into a two-dimensional integral representation with an integrand: the solution of the second-order complex PDE. It is proved that the complex PDE in the general case is reduced to two independent PDEs of the second order with spatially deviating arguments. The geometric and topological features of the two-dimensional subspace on which these equations arise are studied in detail. An algorithm for parallel modeling of the problem has been developed

Kontsentratsiya tsirkuliruyushchikh immunnykh kompleksov i aktivnost' dofamin-r-monooksigenazy v krovi bol'nykh sakharnym diabetom tipa 1 na pozdnikh stadiyakh razvitiya zabolevaniya

Наибольшее количество данных, подтверждающих факт существования единой нейроэндокринноиммунной системы, получены при клинических и модельных исследованиях ряда патологических состояний организма. Очевидно, что СД типа 1 является одной из наиболее показательных моделей в отмеченном аспекте. У больных СД типа 1 имеют место выраженные нарушения специфического и неспецифического иммунитета. Показан ослабленный хемотаксис, фагоцитоз и адгезия нейтрофилов, недостаточная эффективность элиминирования из русла крови циркулирующих иммунных комплексов (ЦИК), низкий уровень в крови С4 компонента комплемента. Одновременно у больных СД типа 1 имеет место дисфункция нервной системы, что проявляется повышением или понижением содержания в мозговой ткани специфических белков и нейропептидов. нарушением гомеостаза ионов Са, повышением содержания в крови серотонина и дофамина (при диабетической нейропатии ). Настоящее исследование было направлено на выявление возможной корреляции между параметрами, отражающими активность адренергических нейронов и иммунной системы при СД типа 1 на поздних стадиях заболевания