Additional file 2: of Characterization of recombination features and the genetic basis in multiple cattle breeds

Correlation between recombination maps of four cattle breeds using the same sample size. The average correlations were calculated from 1000 repeatedly random samples. Each random sample has the same number of meioses across four cattle breeds. Correlations in males were presented in the top-right triangle and female correlations in the bottom-left. The Holstein data have been published previously [15] and are included for comparison purposes. (DOCX 14 kb

Additional file 1: of Characterization of recombination features and the genetic basis in multiple cattle breeds

Eight breed- and sex-specific recombination maps for Holstein, Jersey, Brown Swiss, and Ayrshire in the two sexes. The columns are SNP name, chromosome number, base pair position, recombination rates between current and preceding SNPs in Holstein females, Holstein males, Jersey females, Jersey males, Brown Swiss females, Brown Swiss males, Ayrshire females, and Ayrshire males, respectively. The Holstein data have been published previously [15] and are included for comparison purposes. (RMAP 7191 kb

Additional file 1: of Genome-wide copy number variant analysis reveals variants associated with 10 diverse production traits in Holstein cattle

Figure S1. Box plot for dPTA distribution of the 2 feed intake-related phenotypes of RFI and DMI. (PDF 90 kb

Additional file 2: of Genome-wide copy number variant analysis reveals variants associated with 10 diverse production traits in Holstein cattle

Table S1. Primer information for CNV validation. Table S2. Characteristics of CNV and their overlapped genes. Table S3. Gene ontology (GO) of genes that overlap with CNV. Table S4. CNV-based GWAS results for the 10 phenotypes of interest among Holstein cattle. Table S5. qPCR validation of the significant CNV. (XLSX 96 kb

Additional file 9: Table S9. of CNV discovery for milk composition traits in dairy cattle using whole genome resequencing

Detailed information on the significant SNPs identified in previous GWAS that are near to the 10 candidate genes identified in this study. (XLSX 17 kb

Additional file 7: Table S7. of CNV discovery for milk composition traits in dairy cattle using whole genome resequencing

QTLs covered by differential CNVRs. (XLSX 18 kb

Additional file 1: of Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

Effects of neuronal seipin knockout on Aβ1-42-induced neurotoxicity and neuroinflammation. (116 KB

Additional file 1: Table S1. of CNV discovery for milk composition traits in dairy cattle using whole genome resequencing

Summary of identified CNVs and CNVRs in the 8 bulls’ genomes. (XLSX 1044 kb

Additional file 4: Table S4. of CNV discovery for milk composition traits in dairy cattle using whole genome resequencing

The detailed features of genes completely or partial overlapped with differential CNVRs. (XLSX 28 kb

Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pancreas and reduced the inflammatory infiltration of macrophages in pancreatic tissues. In addition, the expression of pro-inflammatory cytokines was significantly inhibited by the two dendrimers, not only in pancreatic tissues from AP mice but also in vitro in mouse peritoneal macrophages with LPS-induced inflammation. G4.5-COOH, which had better in vivo protective effects for AP than G5-OH, led to a significant reduction in the total number of plasma white blood cells (WBCs) and monocytes in AP mice, and its anti-inflammatory mechanism was related to inhibition of the nuclear translocation of NF-κB in macrophages