Fission decay of N = Z nuclei at high angular momentum: 60^{60}Zn

Using a unique two-arm detector system for heavy ions (the BRS, binary reaction spectrometer) coincident fission events have been measured from the decay of $^{60}$Zn compound nuclei formed at 88MeV excitation energy in the reactions with $^{36}$Ar beams on a $^{24}$Mg target at $E_{lab}(^{36}$Ar) = 195 MeV. The detectors consisted of two large area position sensitive (x,y) gas telescopes with Bragg-ionization chambers. From the binary coincidences in the two detectors inclusive and exclusive cross sections for fission channels with differing losses of charge were obtained. Narrow out-of-plane correlations corresponding to coplanar decay are observed for two fragments emitted in binary events, and in the data for ternary decay with missing charges from 4 up to 8. After subtraction of broad components these narrow correlations are interpreted as a ternary fission process at high angular momentum through an elongated shape. The lighter mass in the neck region consists dominantly of two or three-particles. Differential cross sections for the different mass splits for binary and ternary fission are presented. The relative yields of the binary and ternary events are explained using the statistical model based on the extended Hauser-Feshbach formalism for compound nucleus decay. The ternary fission process can be described by the decay of hyper-deformed states with angular momentum around 45-52 $hbar$.Comment: 23 pages, 25 figure

Atmospheric studies of habitability in the Gliese 581 system

The M-type star Gliese 581 is orbited by at least one terrestrial planet candidate in the habitable zone, i.e. GL 581 d. Orbital simulations have shown that additional planets inside the habitable zone of GL 581 would be dynamically stable. Recently, two further planet candidates have been claimed, one of them in the habitable zone. In view of the ongoing search for planets around M stars which is expected to result in numerous detections of potentially habitable Super-Earths, we take the GL 581 system as an example to investigate such planets. In contrast to previous studies of habitability in the GL 581 system, we use a consistent atmospheric model to assess surface conditions and habitability. Furthermore, we perform detailed atmospheric simulations for a much larger subset of potential planetary and atmospheric scenarios than previously considered. A 1D radiative-convective atmosphere model is used to calculate temperature and pressure profiles of model atmospheres, which we assumed to be composed of molecular nitrogen, water, and carbon dioxide. In these calculations, key parameters such as surface pressure and CO2 concentration as well as orbital distance and planetary mass are varied. Results imply that surface temperatures above freezing could be obtained, independent of the here considered atmospheric scenarios, at an orbital distance of 0.117 AU. For an orbital distance of 0.146 AU, CO2 concentrations as low as 10 times the present Earth's value are sufficient to warm the surface above the freezing point of water. At 0.175 AU, only scenarios with CO2 concentrations of 5% and 95% were found to be habitable. Hence, an additional Super-Earth planet in the GL 581 system in the previously determined dynamical stability range would be considered a potentially habitable planet.Comment: 5 pages, 4 figures, accepted in Astronomy&Astrophysic

The extrasolar planet Gliese 581 d: a potentially habitable planet? (Corrigendum to arXiv:1009.5814)

We report here that the equation for H2O Rayleigh scattering was incorrectly stated in the original paper [arXiv:1009.5814]. Instead of a quadratic dependence on refractivity r, we accidentally quoted an r^4 dependence. Since the correct form of the equation was implemented into the model, scientific results are not affected.Comment: accepted to Astronomy&Astrophysic

Generality of liquid precursor phases in gas diffusion-based calcium carbonate synthesis

The ammonia diffusion method (ADM) is one of the most widely used strategies for the bioinspired synthesis of minerals. Herein, we present investigations of the mineralization mechanism using an advanced ADM to solve the limitations of the conventional ADM. This allows us to confirm the presence of liquid calcium carbonate precursor species in additive-free and polymer-stabilized gas diffusion systems, indicating that liquid-liquid phase separated species exhibit sufficient kinetic stability to be detected. Time-dependent experiments reveal the role of these precursor phases during the early stages of the crystallization process, demonstrating that liquid calcium carbonate mineral precursors play an important role in the precipitation pathway and must be generally considered for the interpretation of gas diffusion experiments, with and without additives. This discovery poses an important step in the understanding of how minerals are formed, highlighting that nonclassical mineralization processes must be considered for material synthesis. Last but not least, the advanced ADM may be useful for the exploration of the formation mechanism of other minerals than calcium carbonate, which are also of broad interest in the materials chemistry community

The population of deformed bands in 48^{48}Cr by emission of 8^{8}Be from the 32^{32}S + 24^{24}Mg reaction

Using particle-$\gamma$ coincidences we have studied the population of final states after the emission of 2 $\alpha$-particles and of $^{8}$Be in nuclei formed in $^{32}$S+$^{24}$Mg reactions at an energy of $\textrm{E}_{\rm L}(^{32}\textrm{S}) = 130 {\rm MeV}$. The data were obtained in a setup consisting of the GASP $\gamma$-ray detection array and the multidetector array ISIS. Particle identification is obtained from the $\Delta$E and E signals of the ISIS silicon detector telescopes, the $^{8}$Be being identified by the instantaneous pile up of the $\Delta$E and E pulses. $\gamma$-ray decays of the $^{48}$Cr nucleus are identified with coincidences set on 2 $\alpha$-particles and on $^{8}$Be. Some transitions of the side-band with $K^\pi=4^{-}$ show stronger population for $^{8}$Be emission relative to that of 2 $\alpha$-particles (by a factor $1.5-1.8$). This observation is interpreted as due to an enhanced emission of $^{8}$Be into a more deformed nucleus. Calculations based on the extended Hauser-Feshbach compound decay formalism confirm this observation quantitatively.Comment: 17 pages, 9 figures accepted for publication in J. Phys.

UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2

On the way to specifically targeting minimal residual disease?

The target of all adjuvant systemic therapies after surgery in breast cancer is the eradication of a minimal subclinical residual disease. Although it is well known that tumor cell dissemination takes place already at an early stage of the disease, little is known about the tumorbiological parameters of these residual cells. Selection of patients eligible for adjuvant endocrine therapies is based on the analysis of receptor expression in the primary tumor – although the analysis is directed against disseminated tumor cells, these cells may vary in receptor expression in comparison with the primary tumor

Bottling Liquid-Like Minerals for Advanced Materials Synthesis

Materials synthesis via liquid-like mineral precursors has been studied since their discovery almost 25 years ago, because their properties offer several advantages, for example, the ability to infiltrate small pores, the production of non-equilibrium crystal morphologies or mimicking textures from biominerals, resulting in a vast range of possible applications. However, the potential of liquid-like precursors has never been fully tapped, and they have received limited attention in the materials chemistry community, largely due to the lack of efficient and scalable synthesis protocols. Herein, the “scalable controlled synthesis and utilization of liquid-like precursors for technological applications” (SCULPT) method is presented, allowing the isolation of the precursor phase on a gram scale, and its advantage in the synthesis of crystalline calcium carbonate materials and respective applications is demonstrated. The effects of different organic and inorganic additives, such as magnesium ions and concrete superplasticizers, on the stability of the precursor are investigated and allow optimizing the process for specific demands. The presented method is easily scalable and therefore allows synthesizing and utilizing the precursor on large scales. Thus, it can be employed for mineral formation during restoration and conservation applications but can also open up pathways toward calcium carbonate-based, CO2-neutral cements

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer - the CONKO 004 pilot trial

BACKGROUND: Advanced pancreatic cancer (APC), beside its high mortality, causes the highest rates of venous thromboembolic events (VTE). Enoxaparin, a low molecular weight heparin (LMWH), is effective in prevention and treatment of VTE. Some small studies indicated that this benefit might extend to patients with cancer and probably prolong survival due to independent mechanisms. We initiated this safety investigation to get feasibility information on intensified chemotherapy combined with LMWH in outpatients with APC treated in 1st line. METHODS: The trial was a prospective, open-label, single center investigation in outpatients with inoperable pancreatic cancer who were treated with intensified first-line chemotherapy along with concomitant application of subcutaneous LMWH. The combined chemotherapy consisted of gemcitabine 1 g/m2 (30 min), 5-FU 750 mg/m2 (24 h), folinic acid 200 mg/m2 (30 min), and Cisplatin 30 mg/m2 (90 min) on day 1 and 8; q3w for the first 12 weeks (GFFC) followed by gemcitabine alone in patients without cancer progression. The simultaneous application of prophylactic enoxaparin started on day 1 of chemotherapy with a fixed dose of 40 mg daily. Statistical analyses were performed using R 3.01 with software package CMPRSK and SPSS software v19.0. RESULTS: The investigation was stopped after recruitment of 19 patients. At this time 15 patients had completed the required 12 weeks of treatment. Based on 71 cycles of GFFC + enoxaparin (median 4/pt [range: 2-4]) and 108 cycles of single-agent gemcitabine + enoxaparin (median 4/pt [range: 0-18]) the cumulative frequency of NCI-CTC toxicities grade 3/4 was below 10%. One case (5%) of a symptomatic non-lethal thromboembolic event was observed while receiving LMWH treatment. No severe bleeding event as defined in the protocol has been observed. The median overall survival was 10.05 [95%CI: 8.67-18.14] months. CONCLUSIONS: The addition of enoxaparin to GFFC chemotherapy is feasible, safe and does not appear to affect the efficacy or the toxicity profile of the chemotherapy regimen in patients with advanced pancreatic adenocarcinoma. Based on these findings we have initiated the randomized CONKO-004 trial to examine whether enoxaparin reduces the incidence of thromboembolic events or increases overall outcome. Trial registration: Clinical Trials NCT01945879