Divergence between the high rate of p53 mutations in skin carcinomas and the low prevalence of anti-p53 antibodies

Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequently p53 mutated. Most skin carcinoma can be diagnosed by examination or biopsy, but aggressive, recurrent and/or non-surgical cases' follow up would be helped by a biological marker of residual disease. We performed a prospective study looking at the prevalence of anti-p53 antibodies using an ELISA technique in a series of 105 skin carcinoma patients in comparison with a sex- and age-matched control skin carcinoma-free group (n = 130). Additionally, p53 accumulation was studied by immunohistochemistry to confirm p53 protein altered expression in a sample of tumours. Anti-p53 antibodies were detected in 2.9% of the cases, with a higher prevalence in patients suffering from the more aggressive squamous cell type (SCC) of skin carcinoma (8%) than for the more common and slowly growing basal cell carcinoma type or BCC (1.5%). p53 protein stabilization could be confirmed in 80% of tumours studied by IHC. This low level of anti-p53 antibody detection contrasts with the high rate of p53 mutations reported in these tumours. This observation shows that the anti-p53 humoral response is a complex and tissue-specific mechanism. © 2001 Cancer Research Campaign http://www.bjcancer.co

Uncovering Ubiquitin and Ubiquitin-like Signaling Networks

Microscopic imaging and technolog

Campagne Mesopac: Leve de sites de forages ODP en sismique multitraces dans le bassin de Nauru

The Mesopac Cruise was the first multichannel seismic study of the western basins of the Pacific Plate. It was concentrated in the Nauru Basin and in the western area of the Central Pacific Basin. Profiles were calibrated with drilling results from DSDP Sites 462 and 169. For the first time one could observe reflectors within the Cretaceous volcanic complex down to approximately equals 8.5 seconds. Profiles did not allow direct observation of the top of the oceanic crust. After correcting for the load on top of the oceanic crust, results suggest that it cannot lie much deeper than those reflectors. If the oceanic crust lies only a few hundred meters beneath the 2.4 km thick complex, it would be right on the normal thermal subsidence curve corresponding to a Jurassic age