Effect of Peppermint Oil on the Characteristics and Physical Stability of Nanostructured Lipid Carrier-CoQ10

Peppermint oil (PO) is one of the essential oils used as a enhancer in nanostructured lipid carriers (NLC), which affects the characteristics and stability of NLC. This study was aimed at determining the effect of PO on the characteristics and stability of NLC-coenzyme Q10 (NLC-CoQ10). NLC containing 1% CoQ10 was added to various concentrations (0, 1, 1.5, and 2%) of PO, namely F1-F4, respectively. The characteristics (odour, shape, viscosity, pH, particle size, and polydispersity index) of F1, F2, F3, and F4 were determined. Physical stability, centrifugation, and thermal cycle tests were performed. The results showed that adding 1-2% PO caused NLC-CoQ10 to have a distinctive PO odour, a spherical shape, and viscosity values of 329.1±10.5, 307.6±27.4, 220.4±4.0, and 219.9±2.2 cps for F1, F2, F3, and F4, respectively. The pH values ranged from 6.33 to 6.36, while the particle sizes were 188.25±13.22, 197.80±14.19, 190.90±9.47, and 187.50±8.71 nm, respectively. The polydispersity index was below 0.3; and the zeta potential values ranged from –44.30 mV to –52.74 mV. F1, F2, and F3 remained stable after 30 days, whereas F4 became more fluid. The formulas performed well in a centrifuge test. The F2, F3, and F4 thermal cycle tests were all stable, but the F1 separated in the first cycle. The addition of 1, 1.5, and 2% PO did not affect the spherical morphology, the pH value, particle size, or the polydispersity index. The addition of 1.5 and 2% PO reduced viscosity, while the addition of 1 and 1.5% reduced zeta potential but increased stability

Pengaruh Penambahan Peppermint Essential Oil Terhadap Karakteristik Dan Stabilitas Fisik (Metode Sentrifugasi) Pada Sistem Nanostructured Lipid Carrier Coq10

CoQ10 is an antioxidant that has low solubility in water so it has a low drug levels in the skin. Nanostructured lipid carrier (NLC) can be used to improve skin penetration; however, NLC has less penetration rate than nanoemulsion (NE). To improve the penetration of NLC, Peppermint Essential Oil (PEO) was used as an enhancer. This study aimed to evaluate the effect of PEO addition at concentrations of 1%; 1.5%; 2% on the characteristics and physical stability of NLC loaded CoQ10. The NLC composed of oleum cacao and beeswax at a ratio of 75: 25, respectively, virgin coconut oil (VCO), Tween 80, Span 80, and propylene glycol. The NLC was prepared by High Shear Homogenization method. Then, the characteristics included organoleptic, pH, particle size, polydispersity index, and zeta potential were determined. Moreover, the physical stability was evaluated by the centrifugation method. The results showed that all samples had a yellowish color with a specific peppermint oil smell. NLC-CoQ10 with the addition of PEO at a concentration of 2% had less viscosity than other formulas. Increasing the concentration of PEO had no significant effects on the color, pH, particle size, and polydispersity index. On the other hand, it decreased the consistency and increased the zeta potential; however, it still produced good physical stability visually observed during the study

Pengaruh Penambahan Peppermint Essential Oil Terhadap Karakteristik Dan Stabilitas Fisik (Metode Sentrifugasi) Pada Sistem Nanostructured Lipid Carrier CoQ10

CoQ10 is an antioxidant that has low solubility in water so it has a low drug levels in the skin. Nanostructured lipid carrier (NLC) can be used to improve skin penetration; however, NLC has less penetration rate than nanoemulsion (NE). To improve the penetration of NLC, Peppermint Essential Oil (PEO) was used as an enhancer. This study aimed to evaluate the effect of PEO addition at concentrations of 1%; 1.5%; 2% on the characteristics and physical stability of NLC loaded CoQ10. The NLC composed of oleum cacao and beeswax at a ratio of 75: 25, respectively, virgin coconut oil (VCO), Tween 80, Span 80, and propylene glycol. The NLC was prepared by High Shear Homogenization method. Then, the characteristics included organoleptic, pH, particle size, polydispersity index, and zeta potential were determined. Moreover, the physical stability was evaluated by the centrifugation method. The results showed that all samples had a yellowish color with a specific peppermint oil smell. NLC-CoQ10 with the addition of PEO at a concentration of 2% had less viscosity than other formulas. Increasing the concentration of PEO had no significant effects on the color, pH, particle size, and polydispersity index. On the other hand, it decreased the consistency and increased the zeta potential; however, it still produced good physical stability visually observed during the study