89 research outputs found
Conductivity of underdoped YBa2Cu3O7-d : evidence for incoherent pair correlations in the pseudogap regime
Conductivity due to superconducting fluctuations studied in optimally doped
YBa2Cu3O7-d films displays a stronger decay law in temperature than explainable
by theory. A formula is proposed, which fits the data very well with two
superconductive parameters, Tc and the coherence length ksi_c0, and an energy
scale Delta*. This is also valid in underdoped materials and enables to
describe the conductivity up to 300 K with a single-particle excitations
channel in parallel with a channel whose contribution is controlled by ksi_c0,
Tc and Delta*.
This allows to address the nature of the pseudogap in favour of incoherent
pairing.Comment: 14 pages, 4 figures, 1 tabl
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID
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