Identification of circles from datapoints using Gaussian sums

We present a pattern recognition method which use datapoints on a plane and estimates the parameters of a circle. MC data are generated in order to test the method's efficiency over noise hits, uncertainty in the hits positions and number of datapoints. The scenario were the hits from a quadrant of the circle are missing is also considered. The method proposed is proven to be robust, accurate and very efficient.Comment: 4 pages, 5 figure

Food heritage makes a difference: The importance of cultural knowledge for improving education for sustainable food choices

This paper presents findings from a study carried out as part of BigPicnic, a European Commission’s Horizon 2020 project. BigPicnic brought together members of the public, scientists, policy-makers and industry representatives to develop exhibitions and science cafés. Across 12 European and one Ugandan botanic gardens participating in the study, we surveyed 1189 respondents on factors and motives affecting their food choices. The study highlights the importance that cultural knowledge holds for understanding food choices and consumer preferences. The findings of this study are discussed in the wider context of food security issues related to sustainable food choice, and the role of food as a form of cultural heritage. Specifically, the findings underline the importance of the impact of food preferences and choices on achieving sustainability, but also indicate that heritage is a key parameter that has to be more explicitly considered in definitions of food security and relevant policies on a European and global level

Combined logical and data-driven models for linking signalling pathways to cellular response

Background Signalling pathways are the cornerstone on understanding cell function and predicting cell behavior. Recently, logical models of canonical pathways have been optimised with high-throughput phosphoproteomic data to construct cell-type specific pathways. However, less is known on how signalling pathways can be linked to a cellular response such as cell growth, death, cytokine secretion, or transcriptional activity. Results In this work, we measure the signalling activity (phosphorylation levels) and phenotypic behavior (cytokine secretion) of normal and cancer hepatocytes treated with a combination of cytokines and inhibitors. Using the two datasets, we construct "extended" pathways that integrate intracellular activity with cellular responses using a hybrid logical/data-driven computational approach. Boolean logic is used whenever a priori knowledge is accessible (i.e., construction of canonical pathways), whereas a data-driven approach is used for linking cellular behavior to signalling activity via non-canonical edges. The extended pathway is subsequently optimised to fit signalling and behavioural data using an Integer Linear Programming formulation. As a result, we are able to construct maps of primary and transformed hepatocytes downstream of 7 receptors that are capable of explaining the secretion of 22 cytokines. Conclusions We developed a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular behaviour. Our results constitute a proof-of-principle for construction of "extended pathways" that are capable of linking pathway activity to diverse responses such as growth, death, differentiation, gene expression, or cytokine secretion.Marie Curie International Reintegration Grants (MIRG-14-CT-2007-046531)Vertex Pharmaceuticals IncorporatedBundesministerium für Wissenschaft und Forschung (HepatoSys)Massachusetts Institute of Technology (Rockwell International Career Development Professorship)Bundesministerium für Wissenschaft und Forschung (HepatoSys 0313081D

Performances of Anode-resistive Micromegas for HL-LHC

Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tracking and trigger- for future HL-LHC upgrade of the experiment. The increase on background and pile-up event probability requires detector performances which are currently under studies in intensive RD activities. We studied performances of four different resistive Micromegas detectors with different read-out strip pitches. These chambers were tested using \sim120 GeV momentum pions, at H6 CERN-SPS beam line in autumn 2010. For a strip pitch 500 micrometers we measure a resolution of \sim90 micrometers and a efficiency of ~98%. The track angle effect on the efficiency was also studied. Our results show that resistive techniques induce no degradation on the efficiency or resolution, with respect to the standard Micromegas. In some configuration the resistive coating is able to reduce the discharge currents at least by a factor of 100.Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tracking and trigger- for future HL-LHC upgrade of the experiment. The increase on background and pile-up event probability requires detector performances which are currently under studies in intensive RD activities. We studied performances of four different resistive Micromegas detectors with different read-out strip pitches. These chambers were tested using \sim120 GeV momentum pions, at H6 CERN-SPS beam line in autumn 2010. For a strip pitch 500 micrometers we measure a resolution of \sim90 micrometers and a efficiency of \sim98%. The track angle effect on the efficiency was also studied. Our results show that resistive techniques induce no degradation on the efficiency or resolution, with respect to the standard Micromegas. In some configuration the resistive coating is able to reduce the discharge currents at least by a factor of 100.Comment: "Presented at the 2011 Hadron Collider Physics symposium (HCP-2011), Paris, France, November 14-18 2011, 3 pages, 6 figures.

Single Polarisation Asymmetries for Quarkonia in Non-relativistic QCD

We find that single spin asymmetries in NRQCD are non-vanishing in general. They are proportional to the imaginary parts of some non-perturbative matrix elements. With statistics of about 10^6 identified J/psi's, or 10^5 identified chi_2, it is possible to measure these imaginary parts even if they are an order of magnitude smaller than the real parts. Such statistics are quite reasonable at polarised HERA N and other future experiments.Comment: Plain LaTeX with one figure (ps

A Gas Leak Rate Measurement System for the ATLAS MUON BIS-Monitored Drift Tubes

A low-cost, reliable and precise system developed for the gas leak rate measurement of the BIS-Monitored Drift Tubes (MDTs) for the ATLAS Muon Spectrometer is presented. In order to meet the BIS-MDT mass production rate, a total number of 100 tubes are tested simultaneously in this setup. The pressure drop of each one of the MDT is measured, within a typical time interval of 48 hours, via a differential manometer comparing with the pressure of a gas tight reference tube. The precision of the method implemented is based on the system temperature homogeneity, with accuracy of ÄT = 0.3 oC. For this reason, two thermally isolated boxes are used testing 50 tubes each of them, to achieve high degree of temperature uniformity and stability. After measuring several thousands of the MDTs, the developed system is confirmed to be appropriate within the specifications for testing the MDTs during the mass production

Brain charts for the human lifespan

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes

The K/pi ratio from condensed Polyakov loops

We perform a field-theoretical computation of hadron production in large systems at the QCD confinement phase transition associated with restoration of the Z(3) global symmetry. This occurs from the decay of a condensate for the Polyakov loop. From the effective potential for the Polyakov loop, its mass just below the confinement temperature T_c is in between the vacuum masses of the pion and that of the kaon. Therefore, due to phase-space restrictions the number of produced kaons is roughly an order of magnitude smaller than that of produced pions, in agreement with recent results from collisions of gold ions at the BNL-RHIC. From its mass, we estimate that the Polyakov loop condensate is characterized by a (spatial) correlation scale of 1/m_\ell ~ 1/2 fm. For systems of deconfined matter of about that size, the free energy may not be dominated by a condensate for the Polyakov loop, and so the process of hadronization may be qualitatively different as compared to large systems. In that vein, experimental data on hadron abundance ratios, for example K/pi, in high-multiplicity pp events at high energies should be very interesting.Comment: 7 pages, 4 figures; discussion of the two-point function of Polyakov Loops in small versus large systems adde