Elli-altmış beş yaş arasındaki postmenopozal Türk kadınlarda, vücut kompozisyonu ve el kavrama gücünün, aksiyal kemik mineral yoğunluğuna etkisi: Yağsız vücut kitlesi belirleyici midir?

Amaç: Postmenopozal kadınlarda, vücut kitle indeksi (VKİ), yağsız vücut kütlesi, yağ kütlesi, ve el kavrama gücü, kemik mineral yoğunluğunun (KMY) belirleyicileridir. Bu çalışmanın amacı, 50 yaş ve üstü kadınlarda, VKİ, vücut kompozisyonu, ve el kavrama gücünün, lomber ve femoral boyun bölgesi KMY üzerine etkisini araştırmaktır. Gereç ve Yöntem: Yaşları 50-65 (55,6±3,9) arasında olan 161 kadın hasta çalışmaya alındı. Kemik mineral yoğunluğu ve vücut kompozisyonu DEXA ile ölçüldü (Norland XR-46). El kavrama gücü JAMAR el dinamometresi ile değerlendirildi. Spearman korelasyon katsayıları hesaplandı. Çeşitli değişkenlerin KMY ile olası ilişkisi açısından multipl lineer regresyon analizi uygulandı. Bulgular: Yağsız vücut kitlesiyle yaş arasında negatif korelasyon saptandı. Yağsız vücut kitlesi lomber ve femur boyun bölgesi ile korele idi. Yağsız vücut kütlesi aynı zamanda el kavrama gücü ve VKİ ile korele idi. El kavrama gücü, yaş ve menopoz süresi ile negatif olarak korele idi. Sonuç: Yağsız vücut kitlesi ve el kavrama gücünün yaşa bağlı olarak azalması, 50-65 yaş arası kadınlarda KMY azalması ile ilişkilidir. Bu yüzden, bu hastalarda, egzersiz ile yağsız vücut kitlesi arttırılmalıdır.Objective: Body mass index, lean mass, fat mass and peripheral muscle strength are often found the determinants of bone mineral density (BMD) in postmenopausal women. The aim of the present study is to investigate the effect of body mass index, body composition and hand grip strength on femoral neck and lumbar spine in postmenopausal women aged 50-65 years. Materials and Methods: We studied 161 women aged 50-65 (55.6±3.9) years. Bone mineral density and body composition were measured by DEXA (Norland X-R 46). Hand grip strength was measured by JAMAR hand held dynamometer. Spearman's correlation's coefficients were calculated. Multiple linear regressions were performed using all variables possibly associated with BMD. Results: Lean mass was correlated negatively with age. Lean mass was correlated with lumbar spine and femoral neck BMD. It was also correlated with hand grip strength and body mass index. Hand grip strength was correlated negatively with age and years since menopause. Conclusion: These results suggest that, age related decline of lean mass and grip strength are associated with the decline of BMD in postmenopausal women aged 50-65 years. Therefore, we encourage these patients to increase lean mass by exercise

COMPARING THE EFFECTS OF PHYSICAL THERAPY AND NON-STEROIDAL ANTI-INFLAMMATORY TREATMENT ON SLEEP QUALITY, QUALITY OF LIFE AND CLINICAL STATUS IN KNEE OSTEOARTHRITIS

Annual European Congress of Rheumatology -- JUN 14-17, 2017 -- Madrid, SPAINAnkarali, Handan Camdeviren/0000-0002-3613-0523; Sahin, Gunsah/0000-0002-4215-6957WOS: 000413181404075

SLEEP QUALITY IN PATIENTS WITH KNEE OSTEOARTHRITIS

Annual European Congress of Rheumatology -- JUN 14-17, 2017 -- Madrid, SPAINAnkarali, Handan Camdeviren/0000-0002-3613-0523; Sahin, Gunsah/0000-0002-4215-6957WOS: 000413181402818

Lumbar and Femoral Bone Mineral Density in Type 2 Turkish Diabetic Patients

The relationship between type 2 diabetes and osteoporosis has not been well established. We studied a population composed of 161 post-menopausal women with type 2 diabetes and a control group. We examined bone mineral density with the dual-energy X-ray absorptiometry(DXA) technique at the lumbar and femoral regions and in a subgroup of patients, we also measured the levels of markers of bone remodelling. We found significantly higher levels of bone mineral density at the lumbar and femoral levels in the diabetic subjects compared with the control group. Moreover, we found higher level of urinary calcium in the controls. On the basis of these results, we suggest that osteoporosis cannot be considered a complication of type 2 diabetes

Serum IGF-1 and IGFBP-3 Levels in Middle Aged Turkish Males: Relationships with Bone Mineral Density and Markers of Bone Turnover (Male Osteoporosis & IGF-1, IGFBP-3) - Original Investigation

Aim: The aim of this study was to determine whether circulating levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were associated with bone mineral density (BMD) and bone turnover markers in middle aged Turkish males. Patients and Methods: At the beginning, a total of 160 Turkish men aged between 35 and 65 years were included to this study. The final sample comprised of 112 men because 48 men were excluded from the study. BMD of the spine and the hip was measured with dual energy x-ray absorptiometry. After an overnight fasting, serum IGF-1, IGFBP-3, intact parathyroid hormone, 25-hydroxy vitamin D, osteocalcin, C-terminal telopeptide, calcium, phosphorous and alkaline phosphatase levels were measured. Urinary concentrations of calcium, phosphorous and creatinine were also estimated. Results: Twenty-one men (18.8%) had a bone mineral density of ≤ -2.5 SD (T score). There was a significant difference in IGF-1 levels between men with normal BMD and men with reduced BMD (132.5 ± 38.1 and 116.1 ± 40.6 respectively and p: 0.04). Serum IGF-1 levels were positively correlated with BMD of the lumbar spine (r: 0.28, p:0.006), but there was no correlation between IGFBP-3 and BMD of any sites tested. IGF-1, IGFBP-3 and BMD were not correlated with bone turnover markers except serum alkaline phosphatase level. Conclusion: Serum IGF-1 levels were lower in men with reduced BMD and positively correlated with BMD of the lumbar spine. Neither IGF-1 nor IGFBP-3 was correlated with bone turnover markers. Further studies of these factors in skeletal cells are needed to explain their role in the pathophysiology of idiopathic male osteoporosis. (From the World of Osteoporosis 2007;13:37-43

Are Bioactive and Free Sex Steroids Associated with Bone Mineral Density and Bone Turnover Markers in Middle Aged Men? - Original Investigation

Aim: To investigate whether bioactive and free sex steroids are associated with bone mineral density (BMD) and bone turnover markers in middle aged men. Material and Methods: One hundred and fifteen out of 165 volunteers aged 35-65 years presenting to our outpatient clinic were included in the study. Serum albumin, total testosterone (T), total estradiol (E2), SHBG, osteocalcin (OC) and C-terminal telopeptide (CTx) levels were measured. Free and bioactive sex steroids, free androgen index (FAI) and free estrogen index (FEI) were calculated. BMD in the lumbar spine and the hip was measured in all participants and effects of sex steroids on BMD and bone turnover markers were investigated. Results: The mean age and the mean body mass index (BMI) in all participants were 52.4±7.8 years and 26.1±3.4 kg/m2 respectively. There was no significant difference in sex hormone levels and bone turnover markers between the individuals with osteoporosis and osteopenia and the individuals with normal BMD (p>0.05). There was a significant relation between age and FAI (r=-0.23, p=0.01), but there was no significant relation between age and bioactive and free sex steroids, FEI and SHBG. However, there was a positive correlation between BMI and bioactive E2 (r=0.35, p:0001), free E2 (r=0.29, p:0.002) and FEI (r=0.39, p=0.0001). After an adjustment for variables effective on BMD was made; no relation was found between BMD measures from the lumbar spine and the hip and serum bioactive sex steroids, free sex steroids, FAI, FEI and SHBG (p>0.05). However, there was a weak positive relation between serum bioactive T, FEI and OC, CTx levels (p=0.05). Conclusion: We think that bioactive and free sex steroids are not independent variables effective on BMD in the spine and the hip in middle aged men and that further studies are needed to elucidate the pathophysiology of idiopathic male osteoporosis. (From the World of Osteoporosis 2009;15:59-65

Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis

Ankarali, Handan Camdeviren/0000-0002-3613-0523; barlas, ibrahim omer/0000-0002-2645-4487; Sahin, Gunsah/0000-0002-4215-6957; Erdal, Mehmet Emin/0000-0002-6191-2930WOS: 000324824500025PubMed: 23749041To investigate associations of the Fas and FasL genes polymorphisms with rheumatoid arthritis (RA). One hundred patients with RA and age-, sex- and ethnically matched 101 controls were included. Four polymorphisms of Fas (-670 A > G rs1800682, -1377 G > A rs2234767) and FasL (IVS2nt-124 A > G rs5030772, -844 T > C rs763110) genes were typed from genomic DNA. Genotype distributions and allelic frequencies were compared between patients and control subjects. After the history and clinical examination of patients with RA, in terms of pain, fatigue and general health status were evaluated by visual analogue scale. Thereafter, erythrocyte sedimentation rate, C-reactive protein, blood count and rheumatoid factor levels were measured. The Disease Activity Score-28, Health Assessment Questionnaire and modified Sharp score were used to evaluate the disease activity, functional disability and radiological damage, and their relationships with the Fas and FasL gene polymorphisms were investigated. In patients with RA, CT and TT genotypes of FasL-844, polymorphism were twofold and 4.8-fold higher, and AA genotype of FasL IVS2nt-124 polymorphism was 3.4-fold higher than the control group (respectively, p = 0.05, p = 0.002, p = 0.039). T allele of FasL-844 polymorphism was more frequent in patients than controls (respectively, 52.5 vs. 41.4 %, p = 0.027). Any association was not detected between Fas (-670 A > G, -1377 G > A) and FasL (-844 T > C, IVS2nt-124 A > G) gene polymorphisms with the disease activity scores, functional disability and radiological damage. However, the Fas-670 A > G polymorphism was associated with drug therapy (p = 0.049). The distribution of GG genotype was higher compared to GA or AA genotypes in patients using triple disease-modifying antirheumatic drug therapy (71.4, 14.3 and 14.3 %, respectively). These findings suggest that the -844 T > C and IVS2nt-124 A > G polymorphisms in the FasL gene related with apoptosis may increase genetic susceptibility to RA in a Turkish population. In addition, the Fas-670 A > G gene polymorphism may be associated with disease progression. There is a need for further studies to clarify the genetic role of apoptosis in RA

Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis

barlas, ibrahim omer/0000-0002-2645-4487; Ankarali, Handan Camdeviren/0000-0002-3613-0523; Erdal, Mehmet Emin/0000-0002-6191-2930; Sahin, Gunsah/0000-0002-4215-6957WOS: 000322120400017PubMed: 23392773To investigate the associations between Fas and FasL gene polymorphisms and susceptibility to knee osteoarthritis. Genomic DNA was obtained from 146 patients with knee osteoarthritis and 102 healthy controls. Genotype distributions and allelic frequencies of four polymorphisms of Fas (-670 G > A rs1800682, -1377 G > A rs2234767) and FasL (IVS2nt-124 A > G rs5030772, -844 T > C rs763110) genes were compared between the groups. Thereafter, this association was investigated between patients and controls of the same sex. There were significant differences between patients with knee osteoarthritis and controls regarding the genotype distributions and allelic frequencies of Fas-1377 G > A polymorphism (P = 0.0001 and P = 0.005, respectively). The Fas-1377 GG genotype and G allele were significantly more frequent in patients with knee osteoarthritis than in controls. Genotype distributions and allelic frequencies of Fas-670 G > A, FasL-844 T > C, and FasL IVS2nt-124 A > G polymorphisms did not differ between the groups (P > 0.05). However, there were no significant differences between patients and controls of the same sex (P > 0.05). These findings suggest that the Fas-1377 G > A polymorphism in the Fas gene related with apoptosis may contribute to susceptibility to knee osteoarthritis in the Turkish population. There is a need for further studies to evaluate the role of apoptosis in large cohorts