6,138 research outputs found
Selective excitation of homogeneous spectral lines
It is possible, for homogeneously broadened lines, to excite selectively the
response signals, which are orders of magnitude narrower than the original
lines. The new type of echo, which allows detecting such signals, and the
formalism, useful for understanding the phenomenon, as well as the experimental
examples from NMR spectroscopy are presented.Comment: 19 pages, 8 figure
Origin of lymph node-derived lymphocytes in human hepatic allografts
Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node. Histologic assessment and immunohistochemical studies verified that T-cell infiltration of donor lymph nodes by recipient-derived lymphocytes occurred early in the post-transplant period. These T cells bore T-cell activation markers, e.g. TAC receptor and HLA-DR antigens. In addition, functional analysis demonstrated alloreactive T cells in secondary proliferation assays. The pattern of alloreactivity in these assays was dependent upon the phenotypic make-up (and therefore origin) of the lymphocytes within the lymph node. A gradual shift in predominance of donor-derived lymphocytes to recipient-derived lymphocytes occurred, but even late in the post-transplant course the stromal elements and a residium of lymphocytes within the lymph nodes continued to bear donor HLA antigens. The possible role of these 'passenger' lymphocytes in allograft immunity is discussed
Dynamics of Neural Networks with Continuous Attractors
We investigate the dynamics of continuous attractor neural networks (CANNs).
Due to the translational invariance of their neuronal interactions, CANNs can
hold a continuous family of stationary states. We systematically explore how
their neutral stability facilitates the tracking performance of a CANN, which
is believed to have wide applications in brain functions. We develop a
perturbative approach that utilizes the dominant movement of the network
stationary states in the state space. We quantify the distortions of the bump
shape during tracking, and study their effects on the tracking performance.
Results are obtained on the maximum speed for a moving stimulus to be
trackable, and the reaction time to catch up an abrupt change in stimulus.Comment: 6 pages, 7 figures with 4 caption
A KINEMATIC ANALYSIS OF TRUNK ABILITY IN WHEELCHAIR FENCING: A PILOT STUDY
The purpose of this study was to explore the trunk ability differences between category A and B participants in wheelchair fencing. The result showed that category B participants might perform similar performance as category A participants in maximum lunge velocity, maximum lunge angle and maximum fast return velocity. This result may provide information to International Wheelchair Fencing Committee (IWFC) for the need of research on Wheelchair Fencing Classification (WFC) to clarify the differences between these two categories of participants
A KINEMATIC ANALYSIS OF TRUNK ABILITY IN WHEELCHAIR FENCING: A PILOT STUDY
The purpose of this study was to explore the trunk ability differences between category A and B participants in wheelchair fencing. The result showed that category B participants might perform similar performance as category A participants in maximum lunge velocity, maximum lunge angle and maximum fast return velocity. This result may provide information to International Wheelchair Fencing Committee (IWFC) for the need of research on Wheelchair Fencing Classification (WFC) to clarify the differences between these two categories of participants
Three years clinical experience with intestinal transplantation
BACKGROUND: After the successful evolution of hepatic transplantation during the last decade, small bowel and multivisceral transplantation remains the sole elusive achievement for the next era of transplant surgeons. Until recently, and for the last thirty years, the results of the sporadic attempts of intestinal transplantation worldwide were discouraging because of unsatisfactory graft and patient survival. The experimental and clinical demonstration of the superior therapeutic efficacy of FK 506, a new immunosuppressive drug, ushered in the current era of small bowel and multivisceral transplantation with initial promising results. STUDY DESIGN: Forty-three consecutive patients with short bowel syndrome, intestinal insufficiency, or malignant tumors with or without associated liver disease, were given intestinal (n=15), hepatic and intestinal (n=21), or multivisceral allografts that contained four or more organs (n=7). Treatment was with FK 506 based immunosuppression. The ascending and right transverse colon were included with the small intestine in 13 of the 43 grafts, almost evenly distributed between the three groups. RESULTS: After six to 39 months, 30 of the 43 patients are alive, 29 bearing grafts. The most rapid convalescence and resumption of diet, as well as the highest three month patient survival (100 percent) and graft survival (88 percent) were with the isolated intestinal procedure. However, this advantage was slowly eroded during the first two postoperative years, in part because the isolated intestine was more prone to rejection. By the end of this time, the best survival rate (86 percent) was with the multivisceral procedure. With all three operations, most of the patients were able to resume diet and discontinue parenteral alimentation, and in the best instances, the quality of life approached normal. However, the surveillance and intensity of care required for these patients for the first year, and in most instances thereafter, was very high, being far more than required for patients having transplants of the liver, kidney or heart. CONCLUSIONS: Although intestinal transplantation has gone through the feasibility phase, strategies will be required to increase its practicality. One possibility is to combine intestinal transplantation with contemporaneous autologous bone marrow transplantation
Abdominal multivisceral transplantation
Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months. Six recipients died: Three from PTLD, one from rejection, one from sepsis, and one from respiratory failure. In addition to rejection, postoperative complications occurring in more than isolated cases included PTLD (n=6), abdominal abscess formation (n=5), pancreatitis (n=3), and ampullary dysfunction (n=2). In addition, infection by enteric microorganisms was common during the early postoperative period. Currently, all 7 survivors are on an oral diet and have normal liver function. Two recipients (one insulin-dependent) require antidiabetes treatment, in one case following distal pancreatectomy and in the other after two episodes of pancreatic rejection. Thus, abdominal multivisceral transplantation is a difficult but feasible operation that demands complex and prolonged posttransplantation management. It is not yet ready for application and awaits a better strategy of immune modulation. © 1995 by Williams & Wilkins
Phase-Remapping Attack in Practical Quantum Key Distribution Systems
Quantum key distribution (QKD) can be used to generate secret keys between
two distant parties. Even though QKD has been proven unconditionally secure
against eavesdroppers with unlimited computation power, practical
implementations of QKD may contain loopholes that may lead to the generated
secret keys being compromised. In this paper, we propose a phase-remapping
attack targeting two practical bidirectional QKD systems (the "plug & play"
system and the Sagnac system). We showed that if the users of the systems are
unaware of our attack, the final key shared between them can be compromised in
some situations. Specifically, we showed that, in the case of the
Bennett-Brassard 1984 (BB84) protocol with ideal single-photon sources, when
the quantum bit error rate (QBER) is between 14.6% and 20%, our attack renders
the final key insecure, whereas the same range of QBER values has been proved
secure if the two users are unaware of our attack; also, we demonstrated three
situations with realistic devices where positive key rates are obtained without
the consideration of Trojan horse attacks but in fact no key can be distilled.
We remark that our attack is feasible with only current technology. Therefore,
it is very important to be aware of our attack in order to ensure absolute
security. In finding our attack, we minimize the QBER over individual
measurements described by a general POVM, which has some similarity with the
standard quantum state discrimination problem.Comment: 13 pages, 8 figure
Rejection of human intestinal allografts: Alone or in combination with the liver
The current results of the present series demonstrate that intestinal allografts are more vulnerable to rejection and continue to be at a significantly higher risk long after transplantation compared with isolated liver allograft recipients. Unexpectedly, a combined liver allograft does not protect small bowel from rejection. The necessarily continuous heavy immunosuppression for these unique recipients is potentially self-defeating. This is clearly demonstrated by their high susceptibility to early and late infectious complications after transplantation as reported in this issue. With the minimal graft-versus-host disease threat in this clinical trial, our revised protocol for future intestinal transplantation is to maximize the passenger leukocyte traffic with supplementary bone marrow from the same intestinal donor in an attempt to augment the development of systemic chimerism and the gradual induction of donor-specific nonreactivity
- …