Significant clusters of the cortical thickness correlation with hours of video gaming per week in the left dorsolateral prefrontal cortex (DLPFC) and left frontal eye fields (FEF) (multiple comparison corrected, <i>p</i><0.01).

<p>Significant clusters of the cortical thickness correlation with hours of video gaming per week in the left dorsolateral prefrontal cortex (DLPFC) and left frontal eye fields (FEF) (multiple comparison corrected, <i>p</i><0.01).</p

One-factor model (A).

<p>Higher-order model (B). (N = 1938).</p

Anatomical locations for the four significant clusters correlated with Compulsivity and three correlated with Externalizing Behaviors identified in the VBM analysis.

<p>Anatomical locations for the four significant clusters correlated with Compulsivity and three correlated with Externalizing Behaviors identified in the VBM analysis.</p

Hierarchical linear regressions predicting symptom severity at 16 years, accounting for site as cluster.

<p>Note. β = Standardised beta; SE = Standard Error</p><p>***<i>p</i>≤.001</p><p>**<i>p</i> ≤ .01</p><p>*<i>p</i> < .05</p><p>GAD = Generalised Anxiety Disorder; MDD = Major Depressive Disorder; ADHD = Attention-Deficit/Hyperactivity Disorder, ODD = Oppositional Defiant Disorder; CD = Conduct Disorder, H = Hopelessness, AS = Anxiety-Sensitivity; IMP = Impulsivity, SS = Sensation-Seeking, Neur = Neuroticism, Extr = Extraversion, Open = Openness, Agree = Agreeableness, Cons = Conscientiousness</p><p>† Results remained unchanged when personality was removed from the model.</p><p>Hierarchical linear regressions predicting symptom severity at 16 years, accounting for site as cluster.</p

Pearson’s <i>r</i> correlation values between emotional biases, personality traits and mental health symptoms at 14 years.

<p>Note. *<i>p</i><.0004 (significance level adjusted for multiple comparisons using the Bonferroni test)</p><p>DAWBA = Development and Well-Being Assessment, GAD = Generalised Anxiety Disorder; MDD = Major Depressive Disorder; ADHD = Attention-Deficit/Hyperactivity Disorder, ODD = Oppositional Defiant Disorder; CD = Conduct Disorder, SURPS = Substance Use and Risk Profile Scale, H = Hopelessness, AS = Anxiety-Sensitivity; IMP = Impulsivity, SS = Sensation-Seeking, NEO-FFI = NEO Five-Factor Inventory; Neur = Neuroticism, Extr = Extraversion, Open = Openness, Agree = Agreeableness, Cons = Conscientiousness</p><p>Pearson’s <i>r</i> correlation values between emotional biases, personality traits and mental health symptoms at 14 years.</p

Fast Accurate Heritability Screening Using Whole-genome Data

Poster submitted to the 2014 Organization for Human Brain Mapping (OHBM) conference in Hamburg, 8-12 June

Relationships between SNP-based estimates of heritability, population variance in functional connectivity and the BOLD response.

<p>A) Relationship between GREML-based heritability estimates (Genetic Variance/Phenotypic Variance) and the population variance (standard deviation, SD) of functional connectivity (node degree) across 25 ROIs for the Ambiguous face viewing contrast. B) Relationship between the population variance (SD) and the population mean of degree across the 25 ROIs. C) Relationship between population mean of the brain response (percent BOLD signal change, %BSC) and the population variance (SD) of degree across the 25 ROIs. For all three plots, colour is scaled according to the GREML results for %BSC (cyan for low values and red for high values). VG, Genetic Variance; Vp, Phenotypic Variance.</p

Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).

<p>Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).</p

SNP-based estimates of heritability and the number of SNPs detected in a GWAS.

<p>Relationship between GREML-based heritability estimates (Genetic Variance/Phenotypic Variance) and the number of single nucleotide polymorphisms (SNPs) showing a significant relationship with percent BOLD signal change (%BSC) at a threshold of p<0.15 (see the <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004523#s2" target="_blank">Results</a> section for rationale). P values for this analysis were obtained using linear regression.</p

Proportion of individuals with connections between a given pair of regions of interest.

<p>Proportion of individuals with connections between a given pair of regions of interest.</p