168 research outputs found
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Einfluß und Auswirkung neuer Techniken/Medien auf das Berufsbild des höheren Dienstes an wissenschaftlichen Bibliotheken / Arbeitsgruppe Neue Techniken/Medien d. Vereins Dt. Bibliothekare: Rudolf Frankenberger ... - Kiel, 1988. - 33 S
Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities
Background In chronic obstructive pulmonary disease (COPD), gender-specifc diferences in the prevalence of symptoms
and comorbidity are known.
Research question We studied whether the relationship between these characteristics depended on gender and carried diag nostic information regarding cardiac comorbidities.
Study design and methods The analysis was based on 2046 patients (GOLD grades 1–4, 795 women; 38.8%) from the
COSYCONET COPD cohort. Assessments comprised the determination of clinical history, comorbidities, lung function,
COPD Assessment Test (CAT) and modifed Medical Research Council dyspnea scale (mMRC). Using multivariate regres sion analyses, gender-specifc diferences in the relationship between symptoms, single CAT items, comorbidities and
functional alterations were determined. To reveal the relationship to cardiac disease (myocardial infarction, or heart failure,
or coronary artery disease) logistic regression analysis was performed separately in men and women.
Results Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), dif fered signifcantly (p<0.05) between men and women. Beyond this, the relationship between functional parameters and
comorbidities versus symptoms showed gender-specifc diferences, especially for single CAT items. In men, item 8 (energy),
mMRC, smoking status, BMI, age and spirometric lung function was related to cardiac disease, while in women primarily
age was predictive.
Interpretation Gender-specifc diferences in COPD not only comprised diferences in symptoms, comorbidities and func tional alterations, but also diferences in their mutual relationships. This was refected in diferent determinants linked to
cardiac disease, thereby indicating that simple diagnostic information might be used diferently in men and women.
Clinical trial registration The cohort study is registered on ClinicalTrials.gov with identifer NCT01245933 and on Ger manCTR.de with identifer DRKS00000284, date of registration November 23, 2010. Further information can be obtained
on the website http://www.asconet.net
Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment
We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to
a pattern of lung function decline consistent with the hypothesis of anti-aging efects of metformin.
Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were
included. The annual decline in lung function (FEV1, FVC) and CO difusing capacity (KCO, TLCO)
in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking
status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well
as metformin-containing therapy compared to patients without diabetes and metformin. Among
2741 patients, 1541 (mean age 64.4 y, 601 female) fulflled the inclusion criteria. In the group with
metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was signifcantly
lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p < 0.05 each), but not the decline of FEV1 and
FVC. These results were confrmed using multiple regression and propensity score analyses. Our
fndings demonstrate an association between the annual decline of lung difusing capacity and the
intake of metformin in patients with COPD consistent with the hypothesis of anti-aging efects of
metformin as refected in a surrogate marker of emphysema
Junge Bibliothek - alte Bestände
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Sekcija mezbibliotecnogo abonementa i dostavki dokumentov
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Subject cataloging in library networks
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Bibliotheksbau und Arbeitsorganisation der neuen bayerischen Universitätsbibliotheken
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Überlegungen zur Automatisierung der Erwerbungsabteilung an der UB Augsburg
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