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Einfluß und Auswirkung neuer Techniken/Medien auf das Berufsbild des höheren Dienstes an wissenschaftlichen Bibliotheken / Arbeitsgruppe Neue Techniken/Medien d. Vereins Dt. Bibliothekare: Rudolf Frankenberger ... - Kiel, 1988. - 33 S

Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities

Background In chronic obstructive pulmonary disease (COPD), gender-specifc diferences in the prevalence of symptoms and comorbidity are known. Research question We studied whether the relationship between these characteristics depended on gender and carried diag nostic information regarding cardiac comorbidities. Study design and methods The analysis was based on 2046 patients (GOLD grades 1–4, 795 women; 38.8%) from the COSYCONET COPD cohort. Assessments comprised the determination of clinical history, comorbidities, lung function, COPD Assessment Test (CAT) and modifed Medical Research Council dyspnea scale (mMRC). Using multivariate regres sion analyses, gender-specifc diferences in the relationship between symptoms, single CAT items, comorbidities and functional alterations were determined. To reveal the relationship to cardiac disease (myocardial infarction, or heart failure, or coronary artery disease) logistic regression analysis was performed separately in men and women. Results Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), dif fered signifcantly (p<0.05) between men and women. Beyond this, the relationship between functional parameters and comorbidities versus symptoms showed gender-specifc diferences, especially for single CAT items. In men, item 8 (energy), mMRC, smoking status, BMI, age and spirometric lung function was related to cardiac disease, while in women primarily age was predictive. Interpretation Gender-specifc diferences in COPD not only comprised diferences in symptoms, comorbidities and func tional alterations, but also diferences in their mutual relationships. This was refected in diferent determinants linked to cardiac disease, thereby indicating that simple diagnostic information might be used diferently in men and women. Clinical trial registration The cohort study is registered on ClinicalTrials.gov with identifer NCT01245933 and on Ger manCTR.de with identifer DRKS00000284, date of registration November 23, 2010. Further information can be obtained on the website http://www.asconet.net

Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment

We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging efects of metformin. Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were included. The annual decline in lung function (FEV1, FVC) and CO difusing capacity (KCO, TLCO) in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well as metformin-containing therapy compared to patients without diabetes and metformin. Among 2741 patients, 1541 (mean age 64.4 y, 601 female) fulflled the inclusion criteria. In the group with metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was signifcantly lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p < 0.05 each), but not the decline of FEV1 and FVC. These results were confrmed using multiple regression and propensity score analyses. Our fndings demonstrate an association between the annual decline of lung difusing capacity and the intake of metformin in patients with COPD consistent with the hypothesis of anti-aging efects of metformin as refected in a surrogate marker of emphysema

Junge Bibliothek - alte Bestände

Junge Bibliothek - alte Bestände. - In: Der Bibliothekar zwischen Praxis und Wissenschaft : Bernhard Sinogowitz zum 65. Geburtstag / hrsg. von Dieter Schug. - Wiesbaden : Harrassowitz, 1986. - S. 119-128. - (Beiträge zum Buch- und Bibliothekswesen ; 24

Sekcija mezbibliotecnogo abonementa i dostavki dokumentov

Sekcija mezbibliotecnogo abonementa i dostavki dokumentov. - In: Bibliotekovedenie i bibliografija za rubezom. 127. 1990. S. 8-1

Non-books in Bibliotheken

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Bibliotheksbau und Arbeitsorganisation der neuen bayerischen Universitätsbibliotheken

Bibliotheksbau und Arbeitsorganisation der neuen bayerischen Universitätsbibliotheken. - In: DFW, Dokumentation, Information. 29. 1981. Sonderheft. S. 33-3

Die Standardschlagwortliste

Die Standardschlagwortliste. - In: Der Österreichische Bibliothekartag: Vorträge und Kommissionssitzungen. - Wien : Vereinigung Österreich. Bibliothekare. - 1986 (1988). - S. 398-405. - (Biblos-Schriften ; 140

Überlegungen zur Automatisierung der Erwerbungsabteilung an der UB Augsburg

Überlegungen zur Automatisierung der Erwerbungsabteilung an der UB Augsburg. - In: Aktuelle Probleme des EDV-Einsatzes in Erwerbung und Katalogisierung. - München : Verl. Dokumentation, 1976. - S. 80-9