Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice.

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states

Facial Re-identification on Non-overlapping Cameras and in Uncontrolled Environments

Face re-identification is an essential task in automatic video surveillance where the identity of the person is known previously. It aims to verify if other cameras have observed a specific face detected by a camera. However, this is a challenging task because of the reduced resolution, and changes in lighting and background available in surveillance video sequences. Furthermore, the face to get re-identified suffers changes in appearance due to expression, pose, and scale. Algorithms need robust descriptors to perform re-identification under these challenging conditions. Among various types of approaches available, correlation filters have properties that can be exploited to achieve a successful re-identification. Our proposal makes use of this approach to exploit both the shape and content of more representative facial images captured by a camera in a field of view. The resulting correlation filters can characterize the face of a person in a field of view; they are good at discriminating faces of different people, tolerant to variable illumination and slight variations in the rotation (in/out of plane) and scale. Further, they allow identifying a person from the first time that has appeared in the camera network. Matching the correlation filters generated in the field of views allows establishing a correspondence between the faces of the same person viewed by different cameras. These results show that facial re-identification under real-world surveillance conditions and biometric context can be successfully performed using correlation filters adequately designed

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice.

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states