4 research outputs found
Making a U-turn on the Purfleet Interchange: Stone Tool Technology in Marine Isotope Stage 9 Britain and the Emergence of the Middle Palaeolithic in Europe
This paper re-examines earlier Palaeolithic core technology from British sites assigned to MIS 11, 9, and 7 using primarily a châine opératoire approach, with the objective of better understanding the earliest occurrence and distribution of Levallois and other prepared-core technologies across the Old World. Contrary to previous interpretations (White and Ashton in Current Anthropology, 44: 598–609, 2003), we find no evidence for a true Levallois concept in MIS 11 or MIS 9 in Britain. Cores previously described as ‘simple prepared cores’ or ‘proto-Levallois’ cores show neither evidence of core management nor predetermination of the resulting flakes. They can instead be explained as the coincidental result of a simpler technological scheme aimed at exploiting the largest surface area of a core, thereby maximising the size of the flakes produced from it. This may be a more widespread practice, or a local solution derived from existing principles. Levallois appears fully formed in Britain during terminal MIS 8/initial MIS 7. Consequently, Britain does not provide evidence for an in situ evolution of Levallois, rather we argue it was introduced by new settlers after a glacial abandonment: the solution to the emergence and significance of Levallois lies in southern Europe, the Levant and Africa
Northern Collaboration Learning Exchange on Embedding Open Access
There has been much preparation over the past couple of years to put in place processes to enable compliance with the HEFCE REF Open Access policy that came into force on 1st April 2016. This preparation was itself building on, in many cases, a number of years of Open Access advocacy. Open Access is now better established than it has ever been, particularly within libraries. The further embedding of Open Access within our institutions remains, though, an ongoing task. At this Learning Exchange, those institutions within the Northern Collaboration that have participated in the Jisc Open Access Pathfinder projects over the past two years will share their experience and the findings from this project activity. All the projects have focused in different ways on embedding Open Access within institutional processes and systems. The day will look at embedding from different perspectives: the Open Access lifecycle, APC management, CRIS/repository systems, and general top tips. The exchange is also open to attendees sharing their own practice where this has proved to be effective. Open Access will require local processes, but there is much we can learn from each other to make it the embedded activity we would like it, and need it, to be. Agenda: 10:00 ? Coffee/tea 10:20 ? Welcome ? The HHuLOA project, to include overview of Pathfinder projects 10:30 ? Session 1 ? The Open Access Lifecycle (including different stakeholder perspectives, link to ERM, link to Jisc Monitor services) - the HHuLOA project 11:30 ? Session 2 ? APC management, experiences and practices - Optimising Resources to Develop a Strategic Approach to Open Access project (Northumbria/Sunderland) / Pathways to Open Access project (UCL/Newcastle/Nottingham) 12:30 ? Lunch 1:15 ? Session 3 ? 3 short presentations on capturing data for HEFCE (system, metadata, and process) - EPrints / PURE / Hydra (and open to DSpace input from other sites) - to include input from opeNWorks project (Manchester and northwest partners) and End to End Open Access (e2eoa) project (Glasgow/Lancaster/Kent/Southampton) 2:15 ? Session 4 ? Making Open Access work across our institutions: Pecha Kucha style good practice sharing with input from the projects and an invitation to attendees to share. Volunteers welcome! 3:15 ? Wrap-up and conclusions from the day. A panel from all projects focusing on next steps. 3:45 ? En
Northern Collaboration Learning Exchange on Embedding Open Access
There has been much preparation over the past couple of years to put in place processes to enable compliance with the HEFCE REF Open Access policy that came into force on 1st April 2016. This preparation was itself building on, in many cases, a number of years of Open Access advocacy. Open Access is now better established than it has ever been, particularly within libraries. The further embedding of Open Access within our institutions remains, though, an ongoing task.
At this Learning Exchange, those institutions within the Northern Collaboration that have participated in the Jisc Open Access Pathfinder projects over the past two years will share their experience and the findings from this project activity. All the projects have focused in different ways on embedding Open Access within institutional processes and systems. The day will look at embedding from different perspectives: the Open Access lifecycle, APC management, CRIS/repository systems, and general top tips.
The exchange is also open to attendees sharing their own practice where this has proved to be effective. Open Access will require local processes, but there is much we can learn from each other to make it the embedded activity we would like it, and need it, to be.
Agenda:
10:00 – Coffee/tea
10:20 – Welcome – The HHuLOA project, to include overview of Pathfinder projects
10:30 – Session 1 – The Open Access Lifecycle (including different stakeholder perspectives, link to ERM, link to Jisc Monitor services) - the HHuLOA project
11:30 – Session 2 – APC management, experiences and practices - Optimising Resources to Develop a Strategic Approach to Open Access project (Northumbria/Sunderland) / Pathways to Open Access project (UCL/Newcastle/Nottingham)
12:30 – Lunch
1:15 – Session 3 – 3 short presentations on capturing data for HEFCE (system, metadata, and process) - EPrints / PURE / Hydra (and open to DSpace input from other sites) - to include input from opeNWorks project (Manchester and northwest partners) and End to End Open Access (e2eoa) project (Glasgow/Lancaster/Kent/Southampton)
2:15 – Session 4 – Making Open Access work across our institutions: Pecha Kucha style good practice sharing with input from the projects and an invitation to attendees to share. Volunteers welcome!
3:15 – Wrap-up and conclusions from the day. A panel from all projects focusing on next steps.
3:45 – En
The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth
We report six patients with array deletions encompassing 12q14. Out of a total of 2538 array investigations carried out on children with developmental delay and dysmorphism in three diagnostic testing centres, six positive cases yielded a frequency of 1 in 423 for this deletion syndrome. The deleted region in each of the six cases overlaps significantly with previously reported cases with microdeletions of this region. The chromosomal range of the deletions extends from 12q13.3q15. In the current study, we report overlapping deletions of variable extent and size but primarily comprising chromosomal bands 12q13.3q14.1. Four of the six deletions were confirmed as de novo events. Two cases had deletions that included HMGA2, and both children had significant short stature. Neither case had osteopoikilosis despite both being deleted for LEMD3. Four cases had deletions that ended proximal to HMGA2 and all of these had much better growth. Five cases had congenital heart defects, including two with atrial septal defects, one each with pulmonary stenosis, sub-aortic stenosis and a patent ductus. Four cases had moderate delay, two had severe developmental delay and a further two had a diagnosis of autism. All six cases had significant speech delay with subtle facial dysmorphism.<br/