6 research outputs found
Dynamic uptake of [<sup>18</sup>F]FAZA %ID/g in tumor (A, C) and muscle (B, D) (median and IQR).
<p><b>A</b> and <b>B</b> show the initial perfusion phase (0–20 min), and <b>C</b> and <b>D</b> show the uptake during 0–3 h (n = 4).</p
Heart rate (A), breathing rate (B) and systolic blood pressure (C) of conscious mice or their littermates under isoflurane or ketamine/xylazine anesthesia breathing air or oxygen.
<p>p-values without asterisks (*) were not significant (after correcting for multiple testing).</p
PET, invasive measurements and physiology values (median and IQR).
<p>PET, invasive measurements and physiology values (median and IQR).</p
T/M-ratios (n = 7–12, left) and representative PET images at 3 h p.i. of mice anesthetized with isoflurane (IF) or ketamine/xylazine (KX) while breathing air or O<sub>2</sub>.
<p>Images and graphs show the static PET evaluation at 1 h (first row), 2 h (second row) and 3 h (third row) after [<sup>18</sup>F]FAZA injection. The image plane is positioned to display the “hottest” tumor voxel. p-values without asterisks (*) were not significant (after correcting for multiple testing).</p
pO<sub>2</sub>-values in tumor (A) and muscle tissue (B).
<p>n = 7–9. p-values without asterisks (*) were not significant (after correcting for multiple testing).</p
Tumor (A) and muscle (B) pO<sub>2</sub> values of mice breathing air for 60 min, followed by 10-min oxygen and air challenges.
<p>Data from individual mice are connected by a line. n = 7–9.</p