Dynamic uptake of [¹⁸F]FAZA %ID/g in tumor (A, C) and muscle (B, D) (median and IQR).

<p><b>A</b> and <b>B</b> show the initial perfusion phase (0–20 min), and <b>C</b> and <b>D</b> show the uptake during 0–3 h (n = 4).</p

Heart rate (A), breathing rate (B) and systolic blood pressure (C) of conscious mice or their littermates under isoflurane or ketamine/xylazine anesthesia breathing air or oxygen.

<p>p-values without asterisks (*) were not significant (after correcting for multiple testing).</p

PET, invasive measurements and physiology values (median and IQR).

<p>PET, invasive measurements and physiology values (median and IQR).</p

T/M-ratios (n = 7–12, left) and representative PET images at 3 h p.i. of mice anesthetized with isoflurane (IF) or ketamine/xylazine (KX) while breathing air or O₂.

<p>Images and graphs show the static PET evaluation at 1 h (first row), 2 h (second row) and 3 h (third row) after [¹⁸F]FAZA injection. The image plane is positioned to display the “hottest” tumor voxel. p-values without asterisks (*) were not significant (after correcting for multiple testing).</p

pO₂-values in tumor (A) and muscle tissue (B).

<p>n = 7–9. p-values without asterisks (*) were not significant (after correcting for multiple testing).</p

Tumor (A) and muscle (B) pO₂ values of mice breathing air for 60 min, followed by 10-min oxygen and air challenges.

<p>Data from individual mice are connected by a line. n = 7–9.</p