19,749 research outputs found
Curvature and torsion in growing actin networks
Intracellular pathogens such as Listeria monocytogenes and Rickettsia
rickettsii move within a host cell by polymerizing a comet-tail of actin fibers
that ultimately pushes the cell forward. This dense network of cross-linked
actin polymers typically exhibits a striking curvature that causes bacteria to
move in gently looping paths. Theoretically, tail curvature has been linked to
details of motility by considering force and torque balances from a finite
number of polymerizing filaments. Here we track beads coated with a prokaryotic
activator of actin polymerization in three dimensions to directly quantify the
curvature and torsion of bead motility paths. We find that bead paths are more
likely to have low rather than high curvature at any given time. Furthermore,
path curvature changes very slowly in time, with an autocorrelation decay time
of 200 seconds. Paths with a small radius of curvature, therefore, remain so
for an extended period resulting in loops when confined to two dimensions. When
allowed to explore a 3D space, path loops are less evident. Finally, we
quantify the torsion in the bead paths and show that beads do not exhibit a
significant left- or right-handed bias to their motion in 3D. These results
suggest that paths of actin-propelled objects may be attributed to slow changes
in curvature rather than a fixed torque
Heat transfer between surfaces in contact: An analytical and experimental study of thermal contact resistance of metallic interfaces
Dimensionless correlation for predicting thermal contact resistance between similar metal surfaces in vacuum environmen
Destruction of chain-superconductivity in YBa_2Cu_4O_8 in a weak magnetic field
We report measurements of the temperature dependent components of the
magnetic penetration depth {\lambda}(T) in single crystal samples of
YBa_2Cu_4O_8 using a radio frequency tunnel diode oscillator technique. We
observe a downturn in {\lambda}(T) at low temperatures for currents flowing
along the b and c axes but not along the a axis. The downturn in {\lambda}_b is
suppressed by a small dc field of ~0.25 T. This and the zero field anisotropy
of {\lambda}(T) likely result from proximity induced superconducting on the CuO
chains, however we also discuss the possibility that a significant part of the
anisotropy might originate from the CuO2 planes.Comment: 5 page
Solubility behaviour, crystallisation kinetics and pour point : a comparison of linear alkane and triacyl glyceride solute/solvent mixtures
Mixtures of either a hydrocarbon wax in a hydrocarbon solvent or a long chain triacyl glyceride (TAG) in a TAG solvent show complex solubility boundary temperature hysteresis and precipitated crystal network formation leading to gelation. For these industrially-important systems, we show how the equilibrium solubility and its hysteresis, crystallisation kinetics and pour point temperature vary with solute concentration for representative examples of both hydrocarbon (n-tetracosane (C24) solute in n-heptane (C7) solvent) and TAG (tristearin (SSS) solute in tricaprylin (CCC) solvent) mixtures. The behaviour is modelled with good accuracy; thereby providing a useful aid to formulation and process optimisation
Implementing vertex dynamics models of cell populations in biology within a consistent computational framework
The dynamic behaviour of epithelial cell sheets plays a central role during development, growth, disease and wound healing. These processes occur as a result of cell adhesion, migration, division, differentiation and death, and involve multiple processes acting at the cellular and molecular level. Computational models offer a useful means by which to investigate and test hypotheses about these processes, and have played a key role in the study of cell–cell interactions. However, the necessarily complex nature of such models means that it is difficult to make accurate comparison between different models, since it is often impossible to distinguish between differences in behaviour that are due to the underlying model assumptions, and those due to differences in the in silico implementation of the model. In this work, an approach is described for the implementation of vertex dynamics models, a discrete approach that represents each cell by a polygon (or polyhedron) whose vertices may move in response to forces. The implementation is undertaken in a consistent manner within a single open source computational framework, Chaste, which comprises fully tested, industrial-grade software that has been developed using an agile approach. This framework allows one to easily change assumptions regarding force generation and cell rearrangement processes within these models. The versatility and generality of this framework is illustrated using a number of biological examples. In each case we provide full details of all technical aspects of our model implementations, and in some cases provide extensions to make the models more generally applicable
Interpretation of the angular dependence of the de Haas-van Alphen effect in MgB_2
We present detailed results for the amplitude and field dependence of the de
Haas-van Alphen (dHvA) signal arising from the electron-like sheet of
Fermi surface in MgB_2. Our data and analysis show that the dip in dHvA
amplitude when the field is close to the basal plane is caused by a beat
between two very similar dHvA frequencies and not a spin-zero effect as
previously assumed. Our results imply that the Stoner enhancement factors in
MgB_2 are small on both the Sigma and Pi sheets.Comment: 4 pages with figures. Submitted to PR
Geometric approach to Fletcher's ideal penalty function
Original article can be found at: www.springerlink.com Copyright Springer. [Originally produced as UH Technical Report 280, 1993]In this note, we derive a geometric formulation of an ideal penalty function for equality constrained problems. This differentiable penalty function requires no parameter estimation or adjustment, has numerical conditioning similar to that of the target function from which it is constructed, and also has the desirable property that the strict second-order constrained minima of the target function are precisely those strict second-order unconstrained minima of the penalty function which satisfy the constraints. Such a penalty function can be used to establish termination properties for algorithms which avoid ill-conditioned steps. Numerical values for the penalty function and its derivatives can be calculated efficiently using automatic differentiation techniques.Peer reviewe
Temperature dependent anisotropy of the penetration depth and coherence length in MgB$_2
We report measurements of the temperature dependent anisotropies
( and ) of both the London penetration depth
and the upper critical field of MgB. Data for
was obtained from measurements of
and on a single crystal sample using a tunnel diode
oscillator technique. was
deduced from field dependent specific heat measurements on the same sample.
and have opposite temperature dependencies, but
close to tend to a common value (). These results are in good agreement with theories
accounting for the two gap nature of MgBComment: 4 pages with figures (New version
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